Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures

Cian Mccafferty Francois David 1 Marcello Venzi Magor Lőrincz Francis Delicata Zoe Atherton Gregorio Recchia Gergely Orban Régis Lambert 2 Giuseppe Di Giovanni 3 Nathalie Leresche 2 Vincenzo Crunelli 4, 5
1 CLESID - Centre Lyonnais d'Etudes de Sécurité Internationale et de Défense
Francophonie - Mondialisation et relations internationales
2 NPA - Neurobiologie des processus adaptatifs
3 University of Malta [Malta]
4 Neuroscience Division, School of Bioscience,
5 Department of Physiology and Biochemistry, Laboratory of Molecular Genetics
Abstract : Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives rise to the paroxysmal oscillations of absence seizures (ASs) remains unknown. Here we report that during ASs in behaving animals, cortico-thalamic excitation drives thalamic firing by preferentially eliciting tonic rather than T-type Ca 2+ channels (T-channels)-dependent burst firing in thalamocortical (TC) neurons, and by temporally framing thalamic output via feed-forward reticular thalamic (NRT)-to-TC neuron inhibition. In TC neurons, overall ictal firing is markedly reduced and bursts rarely occur. Moreover, block of T-channels in cortical and NRT neurons suppresses ASs, but in TC neurons has no effect on seizures or on ictal thalamic output synchrony. These results demonstrate ictal bidirectional cortico-thalamic communications and provide the
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Cian Mccafferty, Francois David, Marcello Venzi, Magor Lőrincz, Francis Delicata, et al.. Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures. Nature Neuroscience, Nature Publishing Group, 2018, 21 (5), pp.744-756. ⟨10.1038/s41593-018-0130-4⟩. ⟨hal-01953249⟩

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