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Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures
Abstract : Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives rise to the paroxysmal oscillations of absence seizures (ASs) remains unknown. Here we report that during ASs in behaving animals, cortico-thalamic excitation drives thalamic firing by preferentially eliciting tonic rather than T-type Ca 2+ channels (T-channels)-dependent burst firing in thalamocortical (TC) neurons, and by temporally framing thalamic output via feed-forward reticular thalamic (NRT)-to-TC neuron inhibition. In TC neurons, overall ictal firing is markedly reduced and bursts rarely occur. Moreover, block of T-channels in cortical and NRT neurons suppresses ASs, but in TC neurons has no effect on seizures or on ictal thalamic output synchrony. These results demonstrate ictal bidirectional cortico-thalamic communications and provide the
Cited literature [69 references]
https://hal.sorbonne-universite.fr/hal-01953249
Contributor : Nathalie Leresche <>
Submitted on : Wednesday, December 12, 2018 - 5:11:54 PM
Last modification on : Friday, March 13, 2020 - 1:56:45 PM
Document(s) archivé(s) le : Wednesday, March 13, 2019 - 4:16:10 PM
Contributor : Nathalie Leresche <>
Submitted on : Wednesday, December 12, 2018 - 5:11:54 PM
Last modification on : Friday, March 13, 2020 - 1:56:45 PM
Document(s) archivé(s) le : Wednesday, March 13, 2019 - 4:16:10 PM
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nihms-80660.pdf
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