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Collective stresses drive competition between monolayers of normal and Ras-transformed cells

Abstract : We study the competition for space between two cell lines that differ only in the expression of the Ras oncogene. The two cell populations are initially separated and set to migrate antagonistically towards an in-between stripe of free substrate. After contact, their interface moves towards the population of normal cells. We interpret the velocity and traction force data taken before and after contact thanks to a hydrodynamic description of collectively migrating cohesive cell sheets. The kinematics of cells, before and after contact, allows us to estimate the relative material parameters for both cell lines. As predicted by the model, the transformed cell population with larger collective stresses pushes the wild type cell population.
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Submitted on : Friday, April 19, 2019 - 2:58:50 PM
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Sarah Moitrier, Carles Blanch-Mercader, Simon Garcia, Kristina Sliogeryte, Tobias Martin, et al.. Collective stresses drive competition between monolayers of normal and Ras-transformed cells. Soft Matter, Royal Society of Chemistry, 2019, ⟨10.1039/C8SM01523F⟩. ⟨hal-02104416⟩

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