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Flyscan opportunities in medicine: the case of quantum rattle based on gold quantum dots

Abstract : The new rapid scan method, Flyscan mode, implemented on the DiffAbs beamline at Synchrotron SOLEIL, allows fast micro-X-ray fluorescence data acquisition. It paves the way for applications in the biomedical field where a large amount of data is needed to generate meaningful information for the clinician. This study presents a complete set of data acquired after injection of gold-cluster-enriched mesoporous silica nanospheres, used as potential theranostic vectors, into rats. While classical X-ray fluorescence investigations (using step-by-step acquisitions) are based on a limited number of samples (approximately one per day at the DiffAbs beamline), the Flyscan mode has enabled gathering information on the interaction of nanometer-scale vectors in different organs such as liver, spleen and kidney at the micrometer scale, for five rats, in only a single five-day synchrotron shift. Moreover, numerous X-ray absorption near-edge structure spectra, which are beam-time-consuming taking into account the low concentration of these theranostic vectors, were collected
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Contributor : Corinne Chanéac <>
Submitted on : Monday, May 13, 2019 - 12:32:16 PM
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Emmanuel Esteve, Solenn Reguer, Cédric Boissière, Corinne Chaneac, Gustavo Lugo, et al.. Flyscan opportunities in medicine: the case of quantum rattle based on gold quantum dots. Journal of Synchrotron Radiation, International Union of Crystallography, 2017, 24 (5), pp.991-999. ⟨10.1107/S1600577517009572⟩. ⟨hal-02127279⟩



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