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Journal articles
Flyscan opportunities in medicine: the case of quantum rattle based on gold quantum dots
Emmanuel Esteve
1, 2
Solenn Reguer
3
Cédric Boissière
4
Corinne Chaneac
4
Gustavo Lugo
2, 5
Chantal Jouanneau
1
Cristian Mocuta
3
Dominique Thiaudière
3
Nicolas Leclercq
3
Bernard Leyh
5
Jean-François Greisch
6
Julien Berthault
3
Michel Daudon
1, 7
Pierre Ronco
7, 1
Dominique Bazin
8, *
*
Corresponding author
8
LCMCP-SMiLES - Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé
LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris
Emmanuel Esteve 1, 2
Author
Solenn Reguer 3
Author
Cédric Boissière 4
Author IdHAL : cedric-boissiere ORCID : https://orcid.org/0000-0003-1212-6850
Corinne Chaneac 4
Author IdHAL : corinne-chaneac ORCID : https://orcid.org/0000-0001-9785-1052
Gustavo Lugo 2, 5
Author
Chantal Jouanneau 1
Author
Cristian Mocuta 3
Author
Dominique Thiaudière 3
Author
Nicolas Leclercq 3
Author
Bernard Leyh 5
Author
Jean-François Greisch 6
Author
Julien Berthault 3
Author
1
Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation (Bâtiment Recherche - 4 rue de la Chine 75970 Paris Cedex 20 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1155 (101, rue de Tolbiac, 75013 Paris - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
2
LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris (11 place Marcelin Berthelot 75231 Paris Cedex 05 - France)
- CdF (institution) - Collège de France (France)
- SU - Sorbonne Université (21 rue de l’École de médecine - 75006 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7574 (France)
3
SSOLEIL - Synchrotron SOLEIL (L'Orme des Merisiers Saint-Aubin - BP 48 91192 GIF-sur-YVETTE CEDEX - France)
- CNRS - Centre National de la Recherche Scientifique : UR1 (France)
4
LCMCP-MHN - Matériaux Hybrides et Nanomatériaux (France)
- LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris (11 place Marcelin Berthelot 75231 Paris Cedex 05 - France)
- CdF (institution) - Collège de France (France)
- SU - Sorbonne Université (21 rue de l’École de médecine - 75006 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7574 (France)
5
Department of Chemistry [Liège] (4000 Liège - Belgium)
- Université de Liège (Place du 20-Août, 7 4000 Liège - Belgium)
6
INT - Institute of Nanotechnology [Karlsruhe] (P.O. Box 3640, 76021 Karlsruhe, Germany - Germany)
- KIT - Karlsruhe Institute of Technology (Campus North, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen / Campus South, Kaiserstraße 12, 76131 Karlsruhe - Germany)
7
CHU Tenon [APHP] (4 Rue de la Chine, 75020 Paris - France)
8
LCMCP-SMiLES - Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (France)
- LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris (11 place Marcelin Berthelot 75231 Paris Cedex 05 - France)
- CdF (institution) - Collège de France (France)
- SU - Sorbonne Université (21 rue de l’École de médecine - 75006 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7574 (France)
Abstract : The new rapid scan method, Flyscan mode, implemented on the DiffAbs beamline at Synchrotron SOLEIL, allows fast micro-X-ray fluorescence data acquisition. It paves the way for applications in the biomedical field where a large amount of data is needed to generate meaningful information for the clinician. This study presents a complete set of data acquired after injection of gold-cluster-enriched mesoporous silica nanospheres, used as potential theranostic vectors, into rats. While classical X-ray fluorescence investigations (using step-by-step acquisitions) are based on a limited number of samples (approximately one per day at the DiffAbs beamline), the Flyscan mode has enabled gathering information on the interaction of nanometer-scale vectors in different organs such as liver, spleen and kidney at the micrometer scale, for five rats, in only a single five-day synchrotron shift. Moreover, numerous X-ray absorption near-edge structure spectra, which are beam-time-consuming taking into account the low concentration of these theranostic vectors, were collected
Document type :
Journal articles
Complete list of metadatas
https://hal.sorbonne-universite.fr/hal-02127279
Contributor : Corinne Chanéac <>
Submitted on : Monday, May 13, 2019 - 12:32:16 PM
Last modification on : Friday, October 30, 2020 - 2:12:02 PM
Contributor : Corinne Chanéac <>
Submitted on : Monday, May 13, 2019 - 12:32:16 PM
Last modification on : Friday, October 30, 2020 - 2:12:02 PM
Identifiers
- HAL Id : hal-02127279, version 1
- DOI : 10.1107/S1600577517009572
Collections
SORBONNE-UNIVERSITE | CDF | CNRS | LCMCP-MHN | INC-CNRS | SYNCHROTRON-SOLEIL | UPMC | LCMCP | U1155 | SU-SCIENCES | SU-MEDECINE | LCMCP-SMILES | PSL
Citation
Emmanuel Esteve, Solenn Reguer, Cédric Boissière, Corinne Chaneac, Gustavo Lugo, et al.. Flyscan opportunities in medicine: the case of quantum rattle based on gold quantum dots. Journal of Synchrotron Radiation, International Union of Crystallography, 2017, 24 (5), pp.991-999. ⟨10.1107/S1600577517009572⟩. ⟨hal-02127279⟩
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