Structural Identification of Antibacterial Lipids from Amazonian Palm Tree Endophytes through the Molecular Network Approach - Sorbonne Université Access content directly
Journal Articles International Journal of Molecular Sciences Year : 2019

Structural Identification of Antibacterial Lipids from Amazonian Palm Tree Endophytes through the Molecular Network Approach

Abstract

A library of 197 endophytic fungi and bacteria isolated from the Amazonian palm tree Astrocaryum sciophilum was extracted and screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Four out of five antibacterial ethyl acetate extracts were also cytotoxic for the MRC-5 cells line. Liquid chromatography coupled to tandem mass spectrometry (UPHLC-HRMS/MS) analyses combined with molecular networking data processing were carried out to allow the identification of depsipeptides and cyclopeptides responsible for the cytotoxicity in the dataset. Specific ion clusters from the active Luteibacter sp. extract were also highlighted using an MRSA activity filter. A chemical study of Luteibacter sp. was conducted leading to the structural characterization of eight fatty acid exhibiting antimicrobial activity against MRSA in the tens of µg/mL range.
Fichier principal
Vignette du fichier
ijms-20-02006.pdf (2.47 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02143840 , version 1 (29-05-2019)

Identifiers

Cite

Morgane Barthélemy, Nicolas Elie, Léonie Pellissier, Jean-Luc Wolfender, Didier Stien, et al.. Structural Identification of Antibacterial Lipids from Amazonian Palm Tree Endophytes through the Molecular Network Approach. International Journal of Molecular Sciences, 2019, 20 (8), pp.2006. ⟨10.3390/ijms20082006⟩. ⟨hal-02143840⟩
87 View
61 Download

Altmetric

Share

Gmail Facebook X LinkedIn More