Organization of Bone Mineral: The Role of Mineral–Water Interactions - Sorbonne Université Access content directly
Journal Articles Geosciences Year : 2018

Organization of Bone Mineral: The Role of Mineral–Water Interactions

Abstract

The mechanism (s) that drive the organization of bone mineral throughout the bone extracellular matrix remain unclear. The long-standing theory implicates the organic matrix, namely specific non-collagenous proteins and/or collagen fibrils, while a recent theory proposes a self-assembly mechanism. Applying a combination of spectroscopic and microscopic techniques in wet and dry conditions to bone-like hydroxyapatite nanoparticles that were used as a proxy for bone mineral, we confirm that mature bone mineral particles have the capacity to self-assemble into organized structures. A large quantity of water is present at the surface of bone mineral due to the presence of a hydrophilic, amorphous surface layer that coats bone mineral nanoparticles. These water molecules must not only be strongly bound to the surface of bone mineral in the form of a rigid hydration shell, but they must also be trapped within the amorphous surface layer. Cohesive forces between these water molecules present at the mineral-mineral interface not only hold the mature bone mineral particles together, but also promote their oriented stacking. This intrinsic ability of mature bone mineral particles to organize themselves without recourse to the organic matrix forms the foundation for the development of the next generation of orthopedic biomaterials.
Fichier principal
Vignette du fichier
geosciences-08-00466.pdf (9.42 Mo) Télécharger le fichier
geosciences-08-00466-s001.pdf (2.65 Mo) Télécharger le fichier
Origin Publication funded by an institution
Loading...

Dates and versions

hal-02144898 , version 1 (31-05-2019)

Identifiers

Cite

Stanislas von Euw, Tsou-Hsi-Camille Chan-Chang, Caroline Paquis, Bernard Haye, Gerard Pehau-Arnaudet, et al.. Organization of Bone Mineral: The Role of Mineral–Water Interactions. Geosciences, 2018, 8 (12), pp.466, 1-18. ⟨10.3390/geosciences8120466⟩. ⟨hal-02144898⟩
160 View
131 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More