Thiabendazole/bentonites hybrids as controlled release systems - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Colloids and Surfaces B: Biointerfaces Année : 2019

Thiabendazole/bentonites hybrids as controlled release systems

Résumé

Clay minerals are commonly used in pharmaceutical products as excipients and active agents. New drug vehicles based on clay minerals have been developed. In this work, sodium (BentNa), calcium (BentCa) and magnesium (BentMg) exchanged bentonites were used for the sorption of thiabendazole (TBZ), and their potential use as controlled release systems was evaluated. Pristine bentonite and exchanged bentonites were characterized by X-ray diffraction, infrared spectroscopy, thermogravimetry and transmission electron microscopy (TEM), and the influence of the different parameters such as pH, contact time and initial concentration of the drug was investigated. The maximum adsorption reached after 45 min period with 2000 mg L−1 of thiabendazole to BentNa and after 105 min with 1300 mg L−1 to BentCa and BentMg, respectively. The maximum adsorbed quantities of thiabendazole were 164.4; 152.3 and 133.3 mg g−1 for BentNa, BentCa and BentMg, respectively. The emission profiles obtained for the bentonite/drug hybrids were similar when simulated body fluids were used and these emission profiles were fitted according to the Korsmeyer-Peppas kinetic model.

Domaines

Chimie
Fichier principal
Vignette du fichier
Manuscript Gracy HAL.pdf (794.15 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02169301 , version 1 (01-07-2019)

Identifiants

Citer

Graycyelle R.S. Cavalcanti, Maria G. Fonseca, Edson da Silva Filho, Maguy Jaber. Thiabendazole/bentonites hybrids as controlled release systems. Colloids and Surfaces B: Biointerfaces, 2019, 176, pp.249-255. ⟨10.1016/j.colsurfb.2018.12.030⟩. ⟨hal-02169301⟩
26 Consultations
342 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More