The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach - Sorbonne Université Access content directly
Journal Articles Scientific Reports Year : 2019

The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach

Abstract

Mankind is on the verge of a postantibiotic era. New concepts are needed in our battle to attenuate infectious diseases around the world and broad spectrum plant-inspired synergistic pharmaceutical preparations should find their place in the global fight against pathogenic microorganisms. To progress towards the discovery of potent antifungal agents against human pathologies, we embarked upon developing chemometric approach coupled with statistical design to unravel the origin of the anticandidal potential of a set of 66 essential oils (EOs). EOs were analyzed by GC-MS and tested against Candida albicans and C. parapsilosis (Minimal Inhibitory Concentration, MIC). An Orthogonal Partial Least Square (OPLS) analysis allowed us to identify six molecules presumably responsible for the anticandidal activity of the oils: (Z)-ligustilide, eugenol, eugenyl acetate, citral, thymol, and β-citronellol. These compounds were combined following a full factorial experimental design approach in order to optimize the anticandidal activity and selectivity index (SI = IC50(MRC5 cells)/MIC) through reconstituted mixtures. (Z)-Ligustilide and citral were the most active compounds, while (Z)-ligustilide and eugenol were the two main factors that most contributed to the increase of the SI. These two terpenes can, therefore, be used to construct bioinspired synergistic anticandidal mixtures.
Fichier principal
Vignette du fichier
s41598-019-45222-y.pdf (1.33 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02173035 , version 1 (04-07-2019)

Licence

Attribution

Identifiers

Cite

Alice M S Rodrigues, Véronique Eparvier, Guillaume Odonne, Nadine Amusant, Didier Stien, et al.. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Scientific Reports, 2019, 9, pp.8729. ⟨10.1038/s41598-019-45222-y⟩. ⟨hal-02173035⟩
230 View
53 Download

Altmetric

Share

Gmail Facebook X LinkedIn More