Structural basis for delta cell paracrine regulation in pancreatic islets - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2019

Structural basis for delta cell paracrine regulation in pancreatic islets

Masahiro Fukuda
  • Fonction : Auteur

Résumé

Little is known about the role of islet delta cells in regulating blood glucose homeostasis in vivo. Delta cells are important paracrine regulators of beta cell and alpha cell secretory activity, however the structural basis underlying this regulation has yet to be determined. Most delta cells are elongated and have a well-defined cell soma and a filopodia-like structure. Using in vivo optogenetics and high-speed Ca2+ imaging, we show that these filopodia are dynamic structures that contain a secretory machinery, enabling the delta cell to reach a large number of beta cells within the islet. This provides for efficient regulation of beta cell activity and is modulated by endogenous IGF-1/VEGF-A signaling. In pre-diabetes, delta cells undergo morphological changes that may be a compensation to maintain paracrine regulation of the beta cell. Our data provides an integrated picture of how delta cells can modulate beta cell activity under physiological conditions.
Fichier principal
Vignette du fichier
s41467-019-11517-x.pdf (2.34 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-02279607 , version 1 (05-09-2019)

Identifiants

Citer

Rafael Arrojo E Drigo, Stefan Jacob, Concha F. García-Prieto, Xiaofeng Zheng, Masahiro Fukuda, et al.. Structural basis for delta cell paracrine regulation in pancreatic islets. Nature Communications, 2019, 10, pp.3700. ⟨10.1038/s41467-019-11517-x⟩. ⟨hal-02279607⟩
201 Consultations
82 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More