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Novel PET tracers: added value for endocrine disorders

Abstract : Nuclear medicine has been implicated in the diagnosis and treatment of endocrine disorders for several decades. With recent development of PET tracers, functional imaging now plays a major role in endocrine tumors enabling with high performance to their localization, characterization, and staging. Besides 18F-FDG, which may be used in the management and follow-up of endocrine tumors, new tracers have emerged, such as 18F-DOPA for neuroendocrine tumors (NETs) (medullary thyroid carcinoma, pheochromocytomas and paragangliomas and well-differentiated NETs originating from the midgut) and 18F-Choline in the field of primary hyperparathyroidism. Moreover, some peptides such as somatostatin analogs can also be used for peptide receptor radionuclide therapy. In this context, Gallium-68 labeled somatostatin analogs (68Ga-SSA) can help to tailor therapeutic choices and follow the response to treatment in the so-called "theranostic" approach. This review emphasizes the usefulness of these three novel PET tracers (18F-Choline, 18F-FDOPA, and 68Ga-SSA) for primary hyperparathyroidism and neuroendocrine tumors.
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Submitted on : Monday, October 28, 2019 - 5:04:18 PM
Last modification on : Wednesday, October 6, 2021 - 3:50:01 PM



Sébastien Bergeret, Judith Charbit, Catherine Ansquer, Géraldine Bera, Philippe Chanson, et al.. Novel PET tracers: added value for endocrine disorders. Endocrine. International Journal of Basic and Clinical Endocrinology , Springer, 2019, ⟨10.1007/s12020-019-01895-z⟩. ⟨hal-02336247⟩



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