Target Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium - Sorbonne Université Access content directly
Journal Articles PLoS ONE Year : 2020

Target Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium

Abstract

The Target Of Rapamycin (TOR) signaling pathway is known to regulate growth in response to nutrient availability and stress in eukaryotic cells. In the present study, we have investigated the TOR pathway in the white-rot fungus Phanerochaete chrysosporium. Inhibition of TOR activity by rapamycin affects conidia germination and hyphal growth highlighting the conserved mechanism of susceptibility to rapamycin. Interestingly, the secreted protein content is also affected by the rapamycin treatment. Finally, homologs of the components of TOR pathway can be identified in P. chrysosporium. Altogether, those results indicate that the TOR pathway of P. chrysosporium plays a central role in this fungus.
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Dates and versions

hal-02797241 , version 1 (05-06-2020)

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Duy Vuong Nguyen, Thomas Roret, Antonio Fernandez-Gonzalez, Annegret Kohler, Melanie Morel-Rouhier, et al.. Target Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium. PLoS ONE, 2020, 15 (2), pp.e0224776. ⟨10.1371/journal.pone.0224776⟩. ⟨hal-02797241⟩
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