Molecular Targets for the Treatment of Metastatic Colorectal Cancer - Sorbonne Université
Journal Articles Cancers Year : 2020

Molecular Targets for the Treatment of Metastatic Colorectal Cancer

Abstract

Over the past years, colorectal cancer (CRC) was subtyped according to its molecular and genetic characteristics, allowing the development of therapeutic strategies, based on predictive biomarkers. Biomarkers such as microsatellite instability (MSI), RAS and BRAF mutations, HER2 amplification or NTRK fusions represent major tools for personalized therapeutic strategies. Moreover, the routine implementation of molecular predictive tests provides new perspectives and challenges for the therapeutic management of CRC patients, such as liquid biopsies and the reintroduction of anti-EGFR monoclonal antibodies. In this review, we summarize the current landscape of targeted therapies for metastatic CRC patients, with a focus on new developments for EGFR blockade and emerging biomarkers (MSI, HER2, NTRK).
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Dates and versions

hal-02991801 , version 1 (06-11-2020)

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Romain Cohen, Thomas Pudlarz, Jean-François Delattre, Raphaël Colle, Thierry André. Molecular Targets for the Treatment of Metastatic Colorectal Cancer. Cancers, 2020, 12 (9), pp.2350. ⟨10.3390/cancers12092350⟩. ⟨hal-02991801⟩
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