Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity? - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Gastroenterology Année : 2020

Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?

Résumé

Gut microbiota plays a role in the pathophysiology of metabolic diseases which also include nonalcoholic fatty liver diseases (NAFLD), through the gut-liver axis. To date, clinical guidelines recommend a weight loss goal of 7 to 10% to improve features of NAFLD. Nevertheless, since this target is not easily achieved by all patients, alternative therapeutic options are currently being evaluated. This review focusses on therapeutics that aims to modulate the gut microbiota and the gut-liver axis. We will herein discuss how probiotics, prebiotics, synbiotic, fecal microbiota transfer, polyphenols, specific diets and exercise interventions have been shown to modify gut microbiota signatures, improve NAFLD outcomes and detail, when available, the different mechanisms by which these beneficial outcomes might occur. Apart from probiotics which have already been tested in human RCTs, most of these potential therapeutics have been studied in animals. Their efficacy still warrants confirmation in humans using appropriate design.
Fichier principal
Vignette du fichier
Aron-Wisnewsky et al. - 2020 - Nonalcoholic Fatty Liver Disease Modulating Gut M.pdf (350.13 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03020123 , version 1 (23-11-2020)

Identifiants

  • HAL Id : hal-03020123 , version 1

Citer

Judith Aron-Wisnewsky, Moritz Warmbrunn, Max Nieuwdorp, Karine Clement. Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?. Gastroenterology, 2020. ⟨hal-03020123⟩
33 Consultations
2039 Téléchargements

Partager

Gmail Mastodon Facebook X LinkedIn More