Skip to Main content Skip to Navigation
Journal articles

Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group

Abstract : The standard of care for patients with advanced cervical cancer (ACC) includes platinum-based chemotherapy. The concept of platinum sensitivity is a major prognostic factor for patients with ovarian cancer. The aim of this study was to validate the applicability of the platinum sensitivity concept to ACC patients, and to estimate its prognostic interest in terms of overall survival (OS) and pattern of recurrence (location, timing). Data of women with histologically proven FIGO 2019 stages IB3–IV ACC, treated between May 2000 and November 2017 with platinum-based regimens, were retrospectively abstracted from 12 institutions from the FRANCOGYN Group. Respective 3-year OSs were 52% (95% CI: 40.8%–66.8%), 21.6% (95% CI: 12.6%–37.2%), and 14.6% (95% CI: 4.2%–50.2%), in case of recurrence <6 months, between 6 and 17 months, and ≥18 months (p < 0.001). Risk of metastatic or multisite recurrence was significantly higher in case of recurrence <6 months, and risk of local or isolated infradiaphragmatic nodal recurrence was significantly higher in case of recurrence >18 months (p < 0.001). In multivariate analysis, platinum sensitivity status was a strong prognostic factor for OS after recurrence, independent of histological grade, lympho-vascular space involvement, final lymph node status, and treatment. Platinum sensitivity status may help to classify patients in three prognostic subgroups for OS after recurrence, and appears to be a strong prognostic factor correlated to the pattern of recurrence
Document type :
Journal articles
Complete list of metadata

https://hal.sorbonne-universite.fr/hal-03062434
Contributor : Gestionnaire Hal-Su <>
Submitted on : Monday, December 14, 2020 - 10:28:43 AM
Last modification on : Tuesday, May 4, 2021 - 12:12:39 PM
Long-term archiving on: : Monday, March 15, 2021 - 6:58:08 PM

File

jcm-09-03646.pdf
Publication funded by an institution

Identifiers

Citation

Tiphaine De Foucher, Cécile Hennebert, Yohan Dabi, Lobna Ouldamer, Vincent Lavoué, et al.. Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group. Journal of Clinical Medicine, MDPI, 2020, 9 (11), pp.3646. ⟨10.3390/jcm9113646⟩. ⟨hal-03062434⟩

Share

Metrics

Record views

101

Files downloads

100