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Journal Articles Colloids and Surfaces B: Biointerfaces Year : 2021

Zn-doped mesoporous hydroxyapatites and their antimicrobial properties


Recently, zinc-based materials have gained immense attention as antimicrobial agents. In this study, zinc-doped mesoporous hydroxyapatites (HAps) with various Zn contents were prepared by co-precipitation using a phosphoprotein as the porous template. The use of the phosphoprotein as the porous template resulted in the formation of zinc-doped mesoporous HAps (mHAps) with large pores and specific surface area (182 m2 g−1), as indicated by the nitrogen adsorption/desorption measurements. The formation of the zinc-doped HAps was confirmed by various analytical techniques such as X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. The biomaterials prepared in this study were used as antimicrobial agents against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria. The Zn2%–mHAp sample showed the maximum bacterial inhibitory concentrations of 50 ± 5% and 77 ± 5% for the Gram-positive and Gram-negative bacteria, respectively. The antibacterial activity of the mHAp samples depended strongly on their Zn2+ content. Thus, the use of a biotemplate and Zn2+ ions is an efficient approach for the formation of novel HAp-based biomaterials with promising antibacterial properties. This synthesis approach will pave a new pathway for the functionalization of other materials for different biomedical applications.
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hal-03142097 , version 1 (15-02-2021)



Cleibson Oliveira de Lima, André Marcorin de Oliveira, Edson Silva Filho, Laís Chantelle, Maguy Jaber, et al.. Zn-doped mesoporous hydroxyapatites and their antimicrobial properties. Colloids and Surfaces B: Biointerfaces, 2021, 198, pp.111471. ⟨10.1016/j.colsurfb.2020.111471⟩. ⟨hal-03142097⟩
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