Skip to Main content Skip to Navigation
Journal articles

Onset of psychiatric signs and impaired neurocognitive domains in inherited metabolic disorders: A case series

Abstract : Inherited metabolic disorders (IMDs) can present with psychiatric signs that vary widely from one disease to another. This picture is further complicated by the fact that these features occur at very different illness time points, which may further delay appropriate diagnosis and treatment. In this case series of 62 children and adolescents suffering from IMDs, we clustered psychiatric signs (on the basis of the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders classification) as well as impaired cognitive domains (on the basis of the Research Domain Criteriamatrix) according to their mean age of onset (5.7 ± 4 years). We observed consistent patterns of occurrence across disorders. Externalizing symptoms, sleep problems, and cross‐domain self‐regulation deficits were found to precede the IMD diagnosis. Repetitive thoughts and behaviors as well as emotional dysregulation were found to occur around the disease onset. Finally, late‐onset features included dissociative or eating disorders, together with impaired emotion knowledge. Clinicians should specifically look for the co‐occurrence of age‐specific atypical signs, such as treatment resistance or worsening with psychotropic medication in the earliest stages and symptom fluctuation, confusion, catatonia, or isolated visual hallucinations. We believe that the combined characterizations of psychiatric signs and impaired neurocognitive domains may enable the earliest detection of IMDs and the appropriate care of these particular manifestations.
Complete list of metadata

https://hal.sorbonne-universite.fr/hal-03142808
Contributor : Hal Sorbonne Université Gestionnaire <>
Submitted on : Tuesday, February 16, 2021 - 12:13:40 PM
Last modification on : Thursday, February 18, 2021 - 3:32:01 AM

File

jmd2.12133.pdf
Publication funded by an institution

Identifiers

Citation

François Medjkane, Marine Bohet, Marielle Ister, David Cohen, Aesa Parenti, et al.. Onset of psychiatric signs and impaired neurocognitive domains in inherited metabolic disorders: A case series. JIMD reports, 2021, ⟨10.1002/jmd2.12133⟩. ⟨hal-03142808⟩

Share

Metrics

Record views

95

Files downloads

17