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FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study

Abstract : Background: FDG-PET/CT is a noninvasive examination that could be helpful for the management of endometrial cancer. The aim of this study was to evaluate the performance of FDG-PET/CT in assessing para-aortic lymph-node involvement in high-risk endometrial cancer. Methods: We performed a retrospective multicenter study including all patients who had a high-risk endometrial cancer with a preoperative FDG-PET/CT and a para-aortic lymphadenectomy (PAL) between 2009 and 2019. The main objective was to evaluate the overall performance of FDG-PET/CT. The secondary objectives were to evaluate its performances according to the histological type and according to FDG-PET/CT date (before or after hysterectomy), and to compare its overall performance with that of the MRI scan. Results: We included 200 patients from six different centers. After the false positive FDG-PET/CT was reread by nuclear physicians, FDG-PET/CT had a sensitivity of 61.8%, a specificity of 89.7%, a positive predictive value of 69.4%, a negative predictive value of 86.1%, and an AUC of 0.76. There were no statistically significant differences in the performances according to either histological type and or FDG-PET/CT date. The sensitivity of FDG-PET/CT was better than that of MRI (p < 0.01), but the specificity was not (p = 0.82). Conclusion: Currently, FDG-PET/CT alone cannot replace PAL for the lymph node evaluation of high-risk endometrial cancers. It seems essential to reread it in multidisciplinary meetings before validating the therapeutic management of patients, particularly in the case of isolated para-aortic involvement.
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Contributor : Gestionnaire Hal-Su <>
Submitted on : Monday, May 3, 2021 - 11:46:44 AM
Last modification on : Wednesday, May 5, 2021 - 3:38:43 AM


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Camille Sallée, François Margueritte, Sébastien Gouy, Antoine Tardieu, Jérémie Belghiti, et al.. FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study. Journal of Clinical Medicine, MDPI, 2021, 10 (8), pp.1746. ⟨10.3390/jcm10081746⟩. ⟨hal-03215299⟩



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