SARS-CoV-2 viral dynamics in infections with variants of concern in the French community
Résumé
We analysed 871,604 PCR tests performed in the community in the Paris area (France) from 1st January 2021 to 24th March 2021. The PCR cycle threshold (Ct) at symptom onset was −1.33 (95% CI [-1.59,-1.07]) and −1.15 (95% CI [-1.57,-0.697]) lower for individuals infected with B.1.1.7 and B.1.351 compared to other strains. The mean duration of infectiousness after symptom onset (time to Ct > 31) was 8.6, 9.3, 8.9 days for individuals infected with historical strains, variants B.1.1.7 and B.1.351. This study clarifies the postsymptom intra-host dynamics of B.1.1.7 and B.1.351 and suggests that higher peak viral load for these variants may explain part of their evolutionary advantage and the greater pathogenicity of B.1.1.7.
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Comparaison souche sauvage versus variants_v6.pdf (608.36 Ko)
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Comparaison souche sauvage versus variants_v6 (1).pdf (608.36 Ko)
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