Formation and evolution of nanoscale calcium phosphate precursors under biomimetic conditions - Sorbonne Université Access content directly
Journal Articles Analytical Chemistry Year : 2021

Formation and evolution of nanoscale calcium phosphate precursors under biomimetic conditions

Abstract

Simulated body fluids (SBFs) that mimic human blood plasma are widely used media for in vitro studies in an extensive array of research fields, from biomineralization to surface and corrosion sciences. We show that these solutions undergo dynamic nanoscopic conformational rearrangements on the timescale of minutes to hours, even though they are commonly considered stable or metastable. In particular, we find and characterize nanoscale inhomogeneities made of calcium phosphate (CaP) aggregates that emerge from homogeneous SBFs within a few hours and evolve into prenucleation species (PNS) that act as precursors in CaP crystallization processes. These ionic clusters consist of ∼2 nm large spherical building units that can aggregate into suprastructures with sizes of over 200 nm. We show that the residence times of phosphate ions in the PNS depend critically on the total PNS surface. These findings are particularly relevant for understanding nonclassical crystallization phenomena, in which PNS are assumed to act as building blocks for the final crystal structure.
Fichier principal
Vignette du fichier
Epasto et al. - 2021 - Formation and Evolution of Nanoscale Calcium Phosp.pdf (2.38 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-03287574 , version 1 (15-07-2021)

Identifiers

Cite

Ludovica Epasto, Tristan Georges, Jean-Michel Guigner, Albina Selimović, Thierry Azaïs, et al.. Formation and evolution of nanoscale calcium phosphate precursors under biomimetic conditions. Analytical Chemistry, 2021, ⟨10.1021/acs.analchem.1c01561⟩. ⟨hal-03287574⟩
67 View
74 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More