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Educational Setting and SARS-CoV-2 Transmission Among Children With Multisystem Inflammatory Syndrome: A French National Surveillance System

Celia Guenver 1, 2, 3 Mehdi Oualha 4, 3 Corinne Levy 5, 6, 3 Denise Antona 7, 3 Fouad Madhi 8, 3 Julie Toubiana 9, 4, 3 Noémie Lachaume 10, 3 Etienne Javouhey 11, 3 Mathie Lorrot 12, 3 David Dawei Yang 3, 4 Michael Levy 1, 3 Marion Caseris 1, 3 Caroline Galeotti 13, 3 Caroline Ovaert 14, 3 Arnaud Wiedemann 15, 3 Marie-Laure Girardin 16, 3 Alexis Rybak 1, 3 Robert Cohen 5, 3 Alexandre Belot 17, 3 François Angoulvant 1, 3 Naïm Ouldali 18, 3, *
Abstract : Background: Multisystem inflammatory syndrome in children (MIS-C) is the most severe form associated with SARS-CoV-2 infection in children. To reduce the spread of SARS-CoV-2 at the population level, educational setting closure have been implemented in many countries. However, the direct benefit of school closure on the MIS-C burden remains to be explored. We aimed to assess the role of educational settings in SARS-CoV-2 transmission among children with MIS-C. Methods: We conducted a French national prospective surveillance of MIS-C, coordinated by Public Health France, from April 2020 to March 2021. During this period, we included all children with MIS-C fulfilling the WHO definition who were reported to Public Health France. For each child, we traced the source of SARS-CoV-2 transmission. The main outcome was the proportion of children with MIS-C, with educational setting-related SARS-CoV-2 infection, during the period of school opening. Results: We included 142 children fulfilling WHO criteria for MIS-C: 104 (70%) cases occurred during school opening periods. In total, 62/104 children (60%, 95%CI [50; 69]) had been contaminated by a household contact and 5/104 in educational settings (5%, 95%CI [2; 11]). Among children with MIS-C occurring during school closure periods, the proportion of household transmission remained similar (66%, 25/38). Conclusion: Children with MIS-C were mainly infected by SARS-CoV-2 within their family environment, and the educational setting played a marginal role in this transmission. This suggests that mitigating school attendance may not reduce substantially the burden of MIS-C.
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Celia Guenver, Mehdi Oualha, Corinne Levy, Denise Antona, Fouad Madhi, et al.. Educational Setting and SARS-CoV-2 Transmission Among Children With Multisystem Inflammatory Syndrome: A French National Surveillance System. Frontiers in Pediatrics, Frontiers, 2021, 9, pp.745364. ⟨10.3389/fped.2021.745364⟩. ⟨hal-03446710⟩

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