Age, COVID-19-like symptoms and SARS-CoV-2 seropositivity profiles after the first wave of the pandemic in France - Sorbonne Université Access content directly
Journal Articles Infection Year : 2021

Age, COVID-19-like symptoms and SARS-CoV-2 seropositivity profiles after the first wave of the pandemic in France

Hélène Blanché
Marie Zins
Xavier de Lamballerie

Abstract

Background The interplay between age and symptoms intensity on antibody response to SARS-CoV-2 infection has not been studied in a general population setting. Methods We explored the serologic profile of anti-SARS-CoV-2 antibodies after the first wave of the pandemic, by assessing IgG against the spike protein (ELISA-S), IgG against the nucleocapsid protein (ELISA-NP) and neutralizing antibodies (SN) in 82,126 adults from a French population-based multi-cohort study. Results ELISA-S positivity was increased in 30-to 49-year-old adults (8.5%) compared to other age groups (5.6% in 20-to 29-year-olds, 2.8% in ≥ 50-year-olds). In the 3681 ELISA-S positive participants, ELISA-NP and SN positivity exhibited a U-shaped relationship with age, with a lower rate in 30-to 49-year-old adults, and was strongly associated with COVID-19-like symptoms. Conclusion Our study confirms the independent role of age and symptoms on the serologic profile of anti-SARS-CoV-2 antibodies, but the non-linear relationship with age deserves further investigation.
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Dates and versions

hal-03456505 , version 1 (30-11-2021)

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Fabrice Carrat, Nathanael Lapidus, Laetitia Ninove, Hélène Blanché, Delphine Rahib, et al.. Age, COVID-19-like symptoms and SARS-CoV-2 seropositivity profiles after the first wave of the pandemic in France. Infection, 2021, 50 (1), pp.257-262. ⟨10.1007/s15010-021-01731-5⟩. ⟨hal-03456505⟩
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