Evidence of sexual transmission of extended-spectrum β-lactamase-producing enterobacterales: a cross-sectional and prospective study - Sorbonne Université Access content directly
Journal Articles Clinical Infectious Diseases Year : 2022

Evidence of sexual transmission of extended-spectrum β-lactamase-producing enterobacterales: a cross-sectional and prospective study

Abstract

Background Extended-spectrum β-lactamase\textendash producing Enterobacterales (ESBL-E) represent a major threat to public health. Little is known on their potential for sexual transmission. Methods We recruited individuals at a sexually transmitted infection and human immunodeficiency virus (HIV) outpatient clinic in Paris, France, in whom we evaluated the prevalence of ESBL-E intestinal carriage and, among those testing positive, the proportion with clearance 6 months thereafter. We compared carriage prevalence between groups using logistic regression adjusted for age, geographic origin, travel outside Europe, and antibiotic use in the past 6 months. Results A total of 2157 individuals participated, of whom 226 (10.5%) were ESBL-E carriers. The proportions of ESBL-E carriers varied across sexual groups and were as follows: HIV-negative men who have sex with men (MSM) and who were on preexposure prophylaxis (PrEP), 16.3% (41 of 251); HIV-negative MSM not on PrEP, 9.7% (47 of 487); HIV-positive MSM, 12.2% (61 of 500); HIV-negative men who have sex exclusively with women, 10.0% (44 of 439); and HIV-negative women who have sex with men, 6.9% (n\hspace0.25em=\hspace0.25em33 of 480). After adjustment, ESBL-E prevalence was significantly higher in HIV-negative MSM on PrEP (P\hspace0.25em<\hspace0.25em.001) and HIV-positive MSM (P\hspace0.25em=\hspace0.25em.01) than in women who have sex with men. A higher number of sexual partners in the past 6 months was associated with ESBL-E carriage after adjustment (P\hspace0.25em=\hspace0.25em.004). Escherichia coli sequence type 14 and blaSHV-12\textendash producing ESBL-E were observed only in MSM. Of 102 individuals with ESBL-E returning for testing, 26 (25%) had carriage at 6 months. Conclusion ESBL-E carriage is more frequent in MSM undergoing PrEP or living with HIV and with increasing number of sexual partners. More research is warranted to understand the consequences of ESBL-E carriage in these populations and how transmission can be reduced.
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hal-03777542 , version 1 (14-09-2022)

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Laure Surgers, Thibault Chiarabini, Guilhem Royer, Hayette Rougier, Mélanie Mercier-Darty, et al.. Evidence of sexual transmission of extended-spectrum β-lactamase-producing enterobacterales: a cross-sectional and prospective study. Clinical Infectious Diseases, 2022, 75 (9), pp.1556-1564. ⟨10.1093/cid/ciac218⟩. ⟨hal-03777542⟩
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