Multiple Sclerosis: Is There a Risk of Worsening after Yellow Fever Vaccination? - Sorbonne Université Access content directly
Journal Articles MULTIPLE SCLEROSIS JOURNAL Year : 2021

Multiple Sclerosis: Is There a Risk of Worsening after Yellow Fever Vaccination?

Abstract

Background: Yellow fever vaccine (YFV) is not advised for multiple sclerosis (MS) patients because of the potential risk of post-vaccine relapses. Objective: To assess the risk of relapsing-remitting multiple sclerosis (RR-MS) worsening after YFV. Methods: Non-interventional observational retrospective, exposed/non-exposed cohort study nested in the French national cohort including MS. Results: 128 RR-MS were included. The 1-year annualized relapse rate (ARR) following YFV did not differ between exposed: 0.219 (0.420) and non-exposed subjects: 0.208 (0.521) ( p\,= 0.92). Time to first relapse was not different between groups (adjusted hazard ratio (HR) = 1.33; 95% confidence interval (CI) = 0.53\textendash 3.30, p = 0.54). Conclusion: These results suggest that YFV does not worsen the course of RR-MS.
No file

Dates and versions

hal-03793513 , version 1 (01-10-2022)

Identifiers

Cite

Caroline Papeix, Julie Mazoyer, Elisabeth Maillart, Caroline Bensa, Anne-Laure Dubessy, et al.. Multiple Sclerosis: Is There a Risk of Worsening after Yellow Fever Vaccination?. MULTIPLE SCLEROSIS JOURNAL, 2021, 27 (14), pp.2280--2283. ⟨10.1177/13524585211006372⟩. ⟨hal-03793513⟩
44 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More