Characteristics Associated with Hospitalisation for COVID-19 in People with Rheumatic Disease: Data from the COVID-19 Global Rheumatology Alliance Physician-Reported Registry - Sorbonne Université Access content directly
Journal Articles Annals of the Rheumatic Diseases Year : 2020

Characteristics Associated with Hospitalisation for COVID-19 in People with Rheumatic Disease: Data from the COVID-19 Global Rheumatology Alliance Physician-Reported Registry

Maria I Danila
  • Function : Author
Elsa F Mateus
  • Function : Author
Julia Simard
  • Function : Author
Suleman Bhana
  • Function : Author
Wendy Costello
  • Function : Author
Paul Sufka
  • Function : Author
Pedro M Machado
  • Function : Author
Philip C Robinson
  • Function : Author

Abstract

Objectives COVID-19 outcomes in people with rheumatic diseases remain poorly understood. The aim was to examine demographic and clinical factors associated with COVID-19 hospitalisation status in people with rheumatic disease. Methods Case series of individuals with rheumatic disease and COVID-19 from the COVID-19 Global Rheumatology Alliance registry: 24 March 2020 to 20 April 2020. Multivariable logistic regression was used to estimate ORs and 95% CIs of hospitalisation. Age, sex, smoking status, rheumatic disease diagnosis, comorbidities and rheumatic disease medications taken immediately prior to infection were analysed. Results A total of 600 cases from 40 countries were included. Nearly half of the cases were hospitalised (277, 46%) and 55 (9%) died. In multivariable-adjusted models, prednisone dose ≥q10\,mg/day was associated with higher odds of hospitalisation (OR 2.05, 95%\,CI 1.06 to 3.96). Use of conventional disease-modifying antirheumatic drug (DMARD) alone or in combination with biologics/Janus Kinase inhibitors was not associated with hospitalisation (OR 1.23, 95%\,CI 0.70 to 2.17 and OR 0.74, 95%\,CI 0.37 to 1.46, respectively). Non-steroidal anti-inflammatory drug (NSAID) use was not associated with hospitalisation status (OR 0.64, 95%\,CI 0.39 to 1.06). Tumour necrosis factor inhibitor (anti-TNF) use was associated with a reduced odds of hospitalisation (OR 0.40, 95%\,CI 0.19 to 0.81), while no association with antimalarial use (OR 0.94, 95%\,CI 0.57 to 1.57) was observed. Conclusions We found that glucocorticoid exposure of ≥q10\,mg/day is associated with a higher odds of hospitalisation and anti-TNF with a decreased odds of hospitalisation in patients with rheumatic disease. Neither exposure to DMARDs nor NSAIDs were associated with increased odds of hospitalisation.
Fichier principal
Vignette du fichier
GRA_AcceptedPaper1.pdf (473.62 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03849959 , version 1 (30-04-2024)

Identifiers

Cite

Milena Gianfrancesco, Kimme L Hyrich, Sarah Al-Adely, Loreto Carmona, Maria I Danila, et al.. Characteristics Associated with Hospitalisation for COVID-19 in People with Rheumatic Disease: Data from the COVID-19 Global Rheumatology Alliance Physician-Reported Registry. Annals of the Rheumatic Diseases, 2020, 79 (7), pp.859--866. ⟨10.1136/annrheumdis-2020-217871⟩. ⟨hal-03849959⟩
36 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More