Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms - Sorbonne Université Access content directly
Journal Articles OncoImmunology Year : 2020

Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms

Abstract

Basophils play an important role in orienting Th2 immune response, and in the pathogenesis of allergic and inflammatory disorders. However, the mechanism by which basophils are kept in check remains unclear and hence we explored the role of regulatory T cells (Treg cells) in this process. We demonstrate that human Treg cells do not suppress rather induce activation of basophils, and promote Th2 responses by IL-3 and STAT5-dependent mechanism.

Dates and versions

hal-03905110 , version 1 (17-12-2022)

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Mrinmoy Das, Emmanuel Stephen-Victor, Jagadeesh Bayry. Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms. OncoImmunology, 2020, 9 (1), pp.1773193. ⟨10.1080/2162402X.2020.1773193⟩. ⟨hal-03905110⟩
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