Sleep Traits, Night Shift Work and Lung Cancer Risk among Women: Results from a Population-Based Case-Control Study in France (The WELCA Study) - Sorbonne Université Access content directly
Journal Articles International Journal of Environmental Research and Public Health Year : 2022

Sleep Traits, Night Shift Work and Lung Cancer Risk among Women: Results from a Population-Based Case-Control Study in France (The WELCA Study)

Abstract

Circadian rhythm disruption due to night shift work and/or sleep disorders is associated with negative health outcomes including cancer. There is only scant evidence of an association with lung cancer, unlike breast and prostate cancer. We explore the role of sleep disorders and night shift work in lung cancer risk among women in a population-based case-control study, including 716 lung cancer cases and 758 controls. Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) associated with sleep duration per day (<7 h, 7–7.9 h, ≥8 h), a summary index of sleep disorders, chronotype, and night shift work exposure metrics. When compared to women with an average sleep duration of 7–7.9 h per day, the OR was 1.39 (95% CI 1.04–1.86) in long sleepers (≥8 h) and 1.16 (95% CI 0.86–1.56) in short sleepers (<7 h). Overall, lung cancer was not associated with the sleep disorder index, nor with night shift work, regardless of the duration of night work or the frequency of night shifts. However, elevated OR associated with the sleep disorder index were found in the subgroup of current smokers. The U-shaped association of lung cancer with sleep duration was more particularly pronounced among women who worked at night ≥5 years. Our findings suggested that sleep patterns are associated with lung cancer risk in women with a potential modifying effect by night shift work duration or tobacco smoking.

Domains

Cancer
Fichier principal
Vignette du fichier
ijerph-19-16246-v2.pdf (399.68 Ko) Télécharger le fichier
Origin Publication funded by an institution

Dates and versions

hal-03906975 , version 1 (20-12-2022)

Licence

Identifiers

Cite

Emilie Cordina-Duverger, Shreeshti Uchai, Nastassia Tvardik, Régine Billmann, Diane Martin, et al.. Sleep Traits, Night Shift Work and Lung Cancer Risk among Women: Results from a Population-Based Case-Control Study in France (The WELCA Study). International Journal of Environmental Research and Public Health, 2022, 19 (23), pp.16246. ⟨10.3390/ijerph192316246⟩. ⟨hal-03906975⟩
26 View
31 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More