Choroid plexus enlargement in inflammatory multiple sclerosis: 3T MRI and translocator protein PET evaluation
Abstract
Summary statement: A combination of 3D MRI and translocator protein PET demonstrated enlarged and inflamed choroid plexuses in patients with multiple sclerosis (MS), representing a potential imaging marker for active MS.
Key results:
Among 97 patients with multiple sclerosis (MS) and 44 controls who underwent a 3T brain MRI and translocator protein PET study, patients had 35% larger choroid plexuses than controls (P=.004).
Choroid plexus enlargement was higher in patients with gadolinium-enhancing lesions (P<.001) and correlated with higher white matter lesion load (r:0.39;P<.001). Choroid plexus size correlated also with neuroinflammation measured by 18F-DPA-714 PET in white matter (r:0.5;P=.005) and thalami (r:0.44;P=.04), and with 4-year annualized relapse rate (r:0.37;P=.005).
Domains
Life Sciences [q-bio]| Origin | Files produced by the author(s) |
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