Choroid plexus enlargement in inflammatory multiple sclerosis: 3T MRI and translocator protein PET evaluation - Sorbonne Université Access content directly
Journal Articles Radiology Year : 2021

Choroid plexus enlargement in inflammatory multiple sclerosis: 3T MRI and translocator protein PET evaluation

Emanuele Morena
  • Function : Author
Annalisa Colombi
  • Function : Author
Matteo Tonietto
  • Function : Author
Mariem Hamzaoui
  • Function : Author
Emilie Poirion
  • Function : Author
Michel Bottlaender
  • Function : Author
Philippe Gervais
  • Function : Author
Celine Louapre
  • Function : Author
Benedetta Bodini
  • Function : Author
Bruno Stankoff

Abstract

Summary statement: A combination of 3D MRI and translocator protein PET demonstrated enlarged and inflamed choroid plexuses in patients with multiple sclerosis (MS), representing a potential imaging marker for active MS. Key results: Among 97 patients with multiple sclerosis (MS) and 44 controls who underwent a 3T brain MRI and translocator protein PET study, patients had 35% larger choroid plexuses than controls (P=.004). Choroid plexus enlargement was higher in patients with gadolinium-enhancing lesions (P<.001) and correlated with higher white matter lesion load (r:0.39;P<.001). Choroid plexus size correlated also with neuroinflammation measured by 18F-DPA-714 PET in white matter (r:0.5;P=.005) and thalami (r:0.44;P=.04), and with 4-year annualized relapse rate (r:0.37;P=.005).
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Dates and versions

hal-03939780 , version 1 (15-01-2023)

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  • HAL Id : hal-03939780 , version 1

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Vito Ag Ricigliano, Emanuele Morena, Annalisa Colombi, Matteo Tonietto, Mariem Hamzaoui, et al.. Choroid plexus enlargement in inflammatory multiple sclerosis: 3T MRI and translocator protein PET evaluation. Radiology, 2021. ⟨hal-03939780⟩
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