CAR-NK Cells: A Chimeric Hope or a Promising Therapy? - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Cancers Année : 2022

CAR-NK Cells: A Chimeric Hope or a Promising Therapy?

Mohamad Sabbah
  • Fonction : Auteur
Ludovic Jondreville
Claire Lacan
  • Fonction : Auteur
Francoise Norol
  • Fonction : Auteur
Damien Roos-Weil
  • Fonction : Auteur
Stéphanie Nguyen

Résumé

Immunotherapy with chimeric antigen receptor-engineered T cells (CAR-T) has revolutionized the treatment landscape of relapsed/refractory B-cell malignancies. Nonetheless, the use of autologous T cells has certain limitations, including the variable quality and quantity of collected effector T cells, extended time of cell processing, limited number of available CAR cells, toxicities, and a high cost. Thanks to their powerful cytotoxic capabilities, with proven antitumor effects in both haploidentical hematopoietic stem cell transplantation and adoptive cell therapy against solid tumors and hematological malignancies, Natural Killer cells could be a promising alternative. Different sources of NK cells can be used, including cellular lines, cord blood, peripheral blood, and induced pluripotent stem cells. Their biggest advantage is the possibility of using them in an allogeneic context without major toxic side effects. However, the majority of the reports on CAR-NK cells concern preclinical or early clinical trials. Indeed, NK cells might be more difficult to engineer, and the optimization and standardization of expansion and transfection protocols need to be defined. Furthermore, their short persistence after infusion is also a major setback. However, with recent advances in manufacturing engineered CAR-NK cells exploiting their cytolytic capacities, antibody-dependent cellular cytotoxicity (ADCC), and cytokine production, “off-the-shelf” allogeneic CAR-NK cells can provide a great potential in cancer treatments.

Dates et versions

hal-03967757 , version 1 (01-02-2023)

Identifiants

Citer

Mohamad Sabbah, Ludovic Jondreville, Claire Lacan, Francoise Norol, Vincent Vieillard, et al.. CAR-NK Cells: A Chimeric Hope or a Promising Therapy?. Cancers, 2022, 14 (15), pp.3839. ⟨10.3390/cancers14153839⟩. ⟨hal-03967757⟩
9 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More