The troubled history of the configuration of the papal apartments of Civita Castellana still represents an open theme, especially regarding the pictorial cycle which until today has not yet reached an in-depth level of investigation in the specialized literature. Originally the apartments were accommodated in a large rectangular covered flat room, which overlooked the valley with three windows. From this main room the pontiff could access two other service rooms that led up to the tower having his name. The appearance of the rooms presumably remained unchanged until the nineteenth century, when the rectangular room was divided with a series of herringbone walls and covered with a barrel vault. The object of this study focuses on the pictorial fragment found in the counter-facade of the entrance, whose pictorial language leads it back, from an initial autopsy analysis to a Borgian commission. Through a path of knowledge based on the complementarity of historical and philological studies and assisted by new digital acquisition technologies, this study aims to virtually reconstruct the pictorial gaps and analyse their architectural language.