Metabolic Syndrome and Osteoarthritis Distribution in the Hand Joints: A Propensity Score Matching Analysis From the Osteoarthritis Initiative - Sorbonne Université Access content directly
Journal Articles Journal of Rheumatology Year : 2021

Metabolic Syndrome and Osteoarthritis Distribution in the Hand Joints: A Propensity Score Matching Analysis From the Osteoarthritis Initiative

Bahram Mohajer
Robert Kwee
  • Function : Author
Ali Guermazi
Francis Berenbaum
Mei Wan
Gehua Zhen
Xu Cao
  • Function : Author
Ida Haugen
Shadpour Demehri

Abstract

Objective. To investigate the metabolic syndrome (MetS) association with radiographic and symptomatic hand osteoarthritis (HOA). Methods. Using 1:2 propensity score matching for relevant confounders, we included 2509 participants (896 MetS positive and 1613 MetS negative) from the Osteoarthritis Initiative dataset. MetS and its components, according to the International Diabetes Federation criteria, were extracted from baseline data, and included hypertension, abdominal obesity, dyslipidemia, and diabetes. We scored distinct hand joints based on the modified Kellgren-Lawrence (mKL) grade of baseline radiographs, with HOA defined as mKL ≥ 2. In the cross-sectional analysis, we investigated the association between MetS and its components with radiographic HOA and the presence of nodal and erosive HOA phenotypes using regression models. In the longitudinal analysis, we performed Cox regression analysis for hand pain incidence in follow-up visits. Results. MetS was associated with higher odds of radiographic HOA, including the number of joints with OA (OR 1.32, 95% CI 1.08–1.62), the sum of joints mKLs (OR 2.42, 95% CI 1.24–4.71), mainly in distal interphalangeal joints (DIPs) and proximal interphalangeal joints (PIPs; OR 1.52, 95% CI 1.08–2.14 and OR 1.38, 95% CI 1.09–1.75, respectively), but not metacarpophalangeal (MCP) and first carpometacarpal (CMC1) joints. Hand pain incidence during follow-up was higher with MetS presence (HR 1.25, 95% CI 1.07–1.47). The erosive HOA phenotype and joints’ nodal involvement were more frequent with MetS (OR 1.40, 95% CI 1.01–1.97 and OR 1.28, 95% CI 1.02–1.60, respectively). Conclusion. MetS, a potentially modifiable risk factor, is associated with radiographic DIP and PIP OA and longitudinal hand pain incidence while sparing MCPs and CMC1s. Nodal and erosive HOA phenotypes are associated with MetS, suggestive of possible distinct pathophysiology.

Dates and versions

hal-03994648 , version 1 (17-02-2023)

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Bahram Mohajer, Robert Kwee, Ali Guermazi, Francis Berenbaum, Mei Wan, et al.. Metabolic Syndrome and Osteoarthritis Distribution in the Hand Joints: A Propensity Score Matching Analysis From the Osteoarthritis Initiative. Journal of Rheumatology, 2021, 48 (10), pp.1608-1615. ⟨10.3899/jrheum.210189⟩. ⟨hal-03994648⟩
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