Microglial phenotypes in the human epileptic temporal lobe - Sorbonne Université Access content directly
Journal Articles Brain - A Journal of Neurology Year : 2018

Microglial phenotypes in the human epileptic temporal lobe

Laurent Jourdren

Abstract

Using transcriptomics, anatomical studies, imaging and ELISA, Morin-Brureau et al. examine microglia in patients with temporal lobe epilepsies. In highly sclerotic regions such as CA1, the anti-inflammatory cytokine IL-10 regulates microglial phenotype. Seizures induce a transient microglial phenotype associated with secretion of inflammatory cytokines including human CXCL8.
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Dates and versions

hal-03997622 , version 1 (20-02-2023)

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Mélanie Morin-Brureau, Giampaolo Milior, Juliette Royer, Farah Chali, Caroline Le Duigou, et al.. Microglial phenotypes in the human epileptic temporal lobe. Brain - A Journal of Neurology , 2018, 141 (12), pp.3343-3360. ⟨10.1093/brain/awy276⟩. ⟨hal-03997622⟩
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