(Electro)chemically synthesis and characterization of new coating having N-halamines groups giving them regenerative antibacterial properties - Sorbonne Université Access content directly
Conference Papers Year : 2018

(Electro)chemically synthesis and characterization of new coating having N-halamines groups giving them regenerative antibacterial properties

Abstract

In the presence of moisture, surfaces are an ideal support for the development of biofilms containing bacteria that can be pathogenic. This poses a real public health problem, economic or even environmental in view of the use of biocides to fight against this phenomenon. The first step in the formation of a biofilm is the adsorption of molecules, especially proteins, followed by the colonization of surfaces by bacteria. The goal of this study is the development of new regenerative antimicrobial coatings, containing haloamine (or N-halamine) functions(> N-Cl or> N-Br) that have oxidative properties due to the degree of oxidation +I (a,b). N-halamines are broad-spectrum biocidal groups; due to their mode of action, i.e. oxidation, bacteria should not develop resistance, unlike after repeated use of antiobiotics. The protection of surfaces with N- halamine compounds requires the immobilization of amine, amide or imine functions that will be transformed into haloamine either during synthesis or by post-treatment in the presence of NaOCl or NaOBr. In this study, we will present a new approach of gold surfaces functionalization with the use of a biopolymer: polydopamine. The synthesis of the polymer has been implemented with two original approaches: a chemical and an electrochemical synthesis. We will present a comparative study of both chemical and electrochemical polymerisation and functionalization of gold surfaces characterized by means of PM- RAIRS, XPS and (E)-QCM surfaces techniques. The control of the polymer thickness shows a clear dependence of the antibacterial response with the degree of chlorination or bromination. Finally, the simple regeneration of the biocidal surfaces will be presented together with the biocidal activity upon re-use of the surfaces
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Dates and versions

hal-04013017 , version 1 (03-03-2023)

Identifiers

  • HAL Id : hal-04013017 , version 1

Cite

Vincent Humblot, Nadia Nazi, Catherine Debiemme-Chouvy. (Electro)chemically synthesis and characterization of new coating having N-halamines groups giving them regenerative antibacterial properties. 2nd Pacific Rim Symposium on Surfaces, Coating & Interfaces, Dec 2018, Waikoloa (Hawaii), United States. ⟨hal-04013017⟩
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