LifeTime and improving European healthcare through cell-based interceptive medicine
Nikolaus Rajewsky
(1, 2, 3, 4)
,
Geneviève Almouzni
(5)
,
Stanislaw A Gorski
(1)
,
Stein Aerts
(6)
,
Ido Amit
(7)
,
Michela G Bertero
(8)
,
Christoph Bock
(9)
,
Annelien L Bredenoord
(10)
,
Giacomo Cavalli
(11)
,
Susanna Chiocca
(12)
,
Hans Clevers
(13, 10, 14, 15)
,
Bart de Strooper
(6, 16)
,
Angelika Eggert
(3, 2)
,
Jan Ellenberg
(17)
,
Xosé M Fernández
(18)
,
Marek Figlerowicz
(19, 20)
,
Susan M Gasser
(21, 22)
,
Norbert Hubner
(2, 3, 4, 23)
,
Jørgen Kjems
(24)
,
Jürgen A Knoblich
(25, 26)
,
Grietje Krabbe
,
Peter Lichter
,
Sten Linnarsson
,
Jean-Christophe Marine
,
John C Marioni
,
Marc A Marti-Renom
,
Mihai G Netea
,
Dörthe Nickel
,
Marcelo Nollmann
(27)
,
Halina R Novak
,
Helen Parkinson
,
Stefano Piccolo
,
Inês Pinheiro
(5)
,
Ana Pombo
,
Christian Popp
,
Wolf Reik
,
Sergio Roman-Roman
,
Philip Rosenstiel
,
Joachim L Schultze
,
Oliver Stegle
,
Amos Tanay
,
Giuseppe Testa
,
Dimitris Thanos
,
Fabian J Theis
,
Maria-Elena Torres-Padilla
,
Alfonso Valencia
,
Céline Vallot
(28)
,
Alexander van Oudenaarden
,
Marie Vidal
,
Thierry Voet
,
Lavinia Alberi
,
Stephanie Alexander
,
Theodore Alexandrov
,
Ernest Arenas
,
Claudia Bagni
,
Robert Balderas
,
Andrea Bandelli
,
Burkhard Becher
,
Matthias Becker
,
Niko Beerenwinkel
,
Monsef Benkirame
,
Marc Beyer
,
Wendy Bickmore
,
Erik E a L Biessen
,
Niklas Blomberg
,
Ingmar Blumcke
,
Bernd Bodenmiller
,
Barbara Borroni
,
Dimitrios T Boumpas
,
Thomas Bourgeron
(29)
,
Sarion Bowers
,
Dries Braeken
,
Catherine Brooksbank
,
Nils Brose
,
Hilgo Bruining
,
Jo Bury
,
Nicolo Caporale
,
Giorgio Cattoretti
,
Nadia Chabane
,
Hervé Chneiweiss
(30, 31, 32)
,
Stuart A Cook
,
Paolo Curatolo
,
Marien I de Jonge
,
Bart Deplancke
,
Bart de Strooper
,
Peter de Witte
,
Stefanie Dimmeler
,
Bogdan Draganski
,
Anna Drews
,
Costica Dumbrava
,
Stefan Engelhardt
,
Thomas Gasser
,
Evangelos J Giamarellos-Bourboulis
,
Caroline Graff
,
Dominic Grün
,
Ivo Gut
,
Oskar Hansson
,
David C Henshall
,
Anna Herland
,
Peter Heutink
,
Stephane R B Heymans
,
Holger Heyn
,
Meritxell Huch
,
Inge Huitinga
,
Paulina Jackowiak
,
Karin R Jongsma
,
Laurent Journot
,
Jan Philipp Junker
,
Shauna Katz
,
Jeanne Kehren
,
Stefan Kempa
,
Paulus Kirchhof
,
Christine Klein
,
Natalia Koralewska
,
Jan O Korbel
,
Malte Kühnemund
,
Angus I Lamond
,
Elsa Lauwers
,
Isabelle Le Ber
,
Ville Leinonen
,
Alejandro Lopez Tobon
,
Emma Lundberg
,
Astrid Lunkes
,
Henrike Maatz
,
Matthias Mann
,
Luca Marelli
,
Vera Matser
,
Paul M Matthews
,
Fatima Mechta-Grigoriou
,
Radhika Menon
,
Anne F Nielsen
,
Massimiliano Pagani
,
R Jeroen Pasterkamp
,
Asla Pitkänen
,
Valentin Popescu
,
Cyril Pottier
,
Alain Puisieux
,
Rosa Rademakers
,
Dory Reiling
,
Orly Reiner
,
Daniel Remondini
,
Craig Ritchie
,
Jonathan D Rohrer
,
Antoine-Emmanuel Saliba
,
Raquel Sanchez-Valle
,
Amedeo Santosuosso
,
Arnold Sauter
,
Richard A Scheltema
,
Philip Scheltens
,
Herbert B Schiller
,
Anja Schneider
,
Philip Seibler
,
Kelly Sheehan-Rooney
,
David Shields
,
Kristel Sleegers
,
August B Smit
,
Kenneth G C Smith
,
Ilse Smolders
,
Matthis Synofzik
,
Wai Long Tam
,
Sarah Teichmann
,
Maria Thom
,
Margherita Y Turco
,
Heleen M M van Beusekom
,
Rik Vandenberghe
,
Silvie van den Hoecke
,
Ibo van de Poel
,
Andre van der Ven
,
Julie van der Zee
,
Jan van Lunzen
,
Geert van Minnebruggen
,
Alexander van Oudenaarden
,
Wim van Paesschen
,
John van Swieten
,
Remko van Vught
,
Matthijs Verhage
,
Patrik Verstreken
,
Carlo Emanuele Villa
,
Jörg Vogel
,
Christof von Kalle
,
Jörn Walter
,
Sarah Weckhuysen
,
Wilko Weichert
,
Louisa Wood
,
Anette-Gabriele Ziegler
,
Frauke Zipp
,
Lavinia Alberi
,
Stephanie Alexander
,
Theodore Alexandrov
,
Ernest Arenas
,
Claudia Bagni
,
Robert Balderas
,
Andrea Bandelli
,
Burkhard Becher
,
Matthias Becker
,
Niko Beerenwinkel
,
Monsef Benkirane
,
Marc Beyer
,
Wendy A. Bickmore
,
Erik E. A. L. Biessen
,
Niklas Blomberg
,
Ingmar Blumcke
,
Bernd Bodenmiller
,
Barbara Borroni
,
Dimitrios T. Boumpas
,
Thomas Bourgeron
,
Sarion Bowers
,
Dries Braeken
,
Catherine Brooksbank
,
Nils Brose
,
Hilgo Bruining
,
Jo Bury
,
Nicolo Caporale
,
Giorgio Cattoretti
,
Nadia Chabane
,
Hervé Chneiweiss
,
Stuart A. Cook
,
Paolo Curatolo
,
Marien I. De Jonge
,
Bart Deplancke
,
Bart De Strooper
,
Peter De Witte
,
Stefanie Dimmeler
,
Bogdan Draganski
,
Anna Drews
,
Costica Dumbrava
,
Stefan Engelhardt
,
Thomas Gasser
,
Evangelos J. Giamarellos-Bourboulis
,
Caroline Graff
,
Dominic Grün
,
Ivo G. Gut
,
Oskar Hansson
,
David C. Henshall
,
Peter Heutink
,
Stephane R. B. Heymans
,
Holger Heyn
,
Meritxell Huch
,
Inge Huitinga
,
Paulina Jackowiak
,
Karin R. Jongsma
,
Laurent Journot
,
Jan Philipp Junker
,
Shauna Katz
,
Jeanne Kehren
,
Stefan Kempa
,
Paulus Kirchhof
,
Christine Klein
,
Natalia Koralewska
,
Jan O. Korbel
,
Malte Kühnemund
,
Angus I. Lamond
,
Elsa Lauwers
,
Isabelle Le Ber
,
Ville Leinonen
,
Alejandro López-Tobón
,
Emma Lundberg
,
Astrid Lunkes
,
Henrike Maatz
,
Matthias Mann
,
Luca Marelli
,
Vera Matser
,
Paul M. Matthews
,
Fatima Mechta-Grigoriou
,
Radhika Menon
,
Anne F. Nielsen
,
Massimiliano Pagani
,
R. Jeroen Pasterkamp
,
Asla Pitkänen
,
Valentin Popescu
,
Cyril Pottier
,
Alain Puisieux
,
Rosa Rademakers
,
Dory Reiling
,
Orly Reiner
,
Daniel Remondini
,
Craig Ritchie
,
Jonathan D. Rohrer
,
Antoine-Emmanuel Saliba
,
Raquel Sanchez-Valle
,
Amedeo Santosuosso
,
Richard A. Scheltema
,
Philip Scheltens
,
Herbert B. Schiller
,
Anja Schneider
,
Philip Seibler
,
Kelly Sheehan-Rooney
,
David J. Shields
,
Kristel Sleegers
,
August B. Smit
,
Kenneth G. C. Smith
,
Ilse Smolders
,
Matthis Synofzik
,
Wai Long Tam
,
Sarah A. Teichmann
,
Maria Thom
,
Margherita Y. Turco
,
Heleen M. M. Van Beusekom
,
Rik Vandenberghe
,
Silvie van Den Hoecke
,
Ibo van De Poel
,
Andre van Der Ven
,
Julie van Der Zee
,
Jan Van Lunzen
,
Geert Van Minnebruggen
,
Alexander Van Oudenaarden
,
Wim Van Paesschen
,
John C. Van Swieten
,
Remko Van Vught
,
Matthijs Verhage
,
Patrik Verstreken
,
Carlo Emanuele Villa
,
Jörg Vogel
,
Christof Von Kalle
,
Jörn Walter
,
Sarah Weckhuysen
,
Wilko Weichert
,
Louisa Wood
,
Anette-Gabriele Ziegler
,
Frauke Zipp
1
Berlin Institute for Medical Systems Biology
2 Charité - UniversitätsMedizin = Berlin University Medicine
3 BIH - Berlin Institute of Health
4 DZHK - German Center for Cardiovascular Research
5 Dynamique du noyau [Institut Curie]
6 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
7 Weizmann Institute of Science [Rehovot, Israël]
8 BIST - Barcelona Institute of Science and Technology
9 CeMM Research Center for Molecular Medicine [Vienna, Austria]
10 UMCU - University Medical Center [Utrecht]
11 IGH - Institut de génétique humaine
12 ESMO - European Institute of Oncology [Milan]
13 KNAW - Royal Netherlands Academy of Arts and Sciences
14 Oncode Institute [Utrecht]
15 Princess Máxima Center for Pediatric Oncology [Utrecht, Netherlands]
16 UCL - University College of London [London]
17 EMBL - European Molecular Biology Laboratory [Heidelberg]
18 Institut Curie [Paris]
19 PAN - Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences
20 PUT - Poznan University of Technology
21 FMI - Friedrich Miescher Institute for Biomedical Research
22 Unibas - Université de Bâle = University of Basel = Basel Universität
23 MDC - Max Delbrück Center for Molecular Medicine [Berlin]
24 Aarhus University [Aarhus]
25 OeAW - Austrian Academy of Sciences
26 Medizinische Universität Wien = Medical University of Vienna
27 CBS - Centre de Biologie Structurale [Montpellier]
28 DIG CANCER - Dynamique de l'information génétique : bases fondamentales et cancer
29 GHFC (UMR_3571 / U-Pasteur_1) - Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions
30 NPS - Neuroscience Paris Seine
31 IBPS - Institut de Biologie Paris Seine
32 NPS - Plasticité gliale et neuro-oncologie = Glial Plasticity
2 Charité - UniversitätsMedizin = Berlin University Medicine
3 BIH - Berlin Institute of Health
4 DZHK - German Center for Cardiovascular Research
5 Dynamique du noyau [Institut Curie]
6 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
7 Weizmann Institute of Science [Rehovot, Israël]
8 BIST - Barcelona Institute of Science and Technology
9 CeMM Research Center for Molecular Medicine [Vienna, Austria]
10 UMCU - University Medical Center [Utrecht]
11 IGH - Institut de génétique humaine
12 ESMO - European Institute of Oncology [Milan]
13 KNAW - Royal Netherlands Academy of Arts and Sciences
14 Oncode Institute [Utrecht]
15 Princess Máxima Center for Pediatric Oncology [Utrecht, Netherlands]
16 UCL - University College of London [London]
17 EMBL - European Molecular Biology Laboratory [Heidelberg]
18 Institut Curie [Paris]
19 PAN - Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences
20 PUT - Poznan University of Technology
21 FMI - Friedrich Miescher Institute for Biomedical Research
22 Unibas - Université de Bâle = University of Basel = Basel Universität
23 MDC - Max Delbrück Center for Molecular Medicine [Berlin]
24 Aarhus University [Aarhus]
25 OeAW - Austrian Academy of Sciences
26 Medizinische Universität Wien = Medical University of Vienna
27 CBS - Centre de Biologie Structurale [Montpellier]
28 DIG CANCER - Dynamique de l'information génétique : bases fondamentales et cancer
29 GHFC (UMR_3571 / U-Pasteur_1) - Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions
30 NPS - Neuroscience Paris Seine
31 IBPS - Institut de Biologie Paris Seine
32 NPS - Plasticité gliale et neuro-oncologie = Glial Plasticity
Geneviève Almouzni
- Function : Author
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Stanislaw A Gorski
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Stein Aerts
- Function : Author
- PersonId : 760396
- ORCID : 0000-0002-8006-0315
Ido Amit
- Function : Author
- PersonId : 779298
- ORCID : 0000-0003-2968-877X
Christoph Bock
- Function : Author
- PersonId : 1236047
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Annelien L Bredenoord
- Function : Author
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Giacomo Cavalli
- Function : Author
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Susanna Chiocca
- Function : Author
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Jan Ellenberg
- Function : Author
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- ORCID : 0000-0001-5909-701X
Xosé M Fernández
- Function : Author
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- ORCID : 0000-0001-7139-6215
Susan M Gasser
- Function : Author
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Jürgen A Knoblich
- Function : Author
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Grietje Krabbe
- Function : Author
Peter Lichter
- Function : Author
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Sten Linnarsson
- Function : Author
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Jean-Christophe Marine
- Function : Author
John C Marioni
- Function : Author
- PersonId : 800336
- ORCID : 0000-0001-9092-0852
Marc A Marti-Renom
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- PersonId : 811870
- ORCID : 0000-0002-0151-4279
Mihai G Netea
- Function : Author
- PersonId : 1236056
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Dörthe Nickel
- Function : Author
Marcelo Nollmann
- Function : Author
- PersonId : 176559
- IdHAL : marcnol
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Halina R Novak
- Function : Author
Helen Parkinson
- Function : Author
Stefano Piccolo
- Function : Author
- PersonId : 1236057
- ORCID : 0000-0002-1600-3092
Ana Pombo
- Function : Author
- PersonId : 1236058
- ORCID : 0000-0002-7493-6288
Christian Popp
- Function : Author
Wolf Reik
- Function : Author
- PersonId : 1236059
- ORCID : 0000-0003-0216-9881
Sergio Roman-Roman
- Function : Author
Philip Rosenstiel
- Function : Author
Joachim L Schultze
- Function : Author
- PersonId : 1182954
- ORCID : 0000-0003-2812-9853
Oliver Stegle
- Function : Author
Amos Tanay
- Function : Author
- PersonId : 784442
- ORCID : 0000-0001-9419-3824
Giuseppe Testa
- Function : Author
Dimitris Thanos
- Function : Author
Fabian J Theis
- Function : Author
- PersonId : 1182957
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Maria-Elena Torres-Padilla
- Function : Author
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Alfonso Valencia
- Function : Author
Céline Vallot
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Alexander van Oudenaarden
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Marie Vidal
- Function : Author
- PersonId : 1236062
- ORCID : 0000-0003-1186-9994
Thierry Voet
- Function : Author
Lavinia Alberi
- Function : Author
Stephanie Alexander
- Function : Author
Theodore Alexandrov
- Function : Author
Ernest Arenas
- Function : Author
Claudia Bagni
- Function : Author
Robert Balderas
- Function : Author
Andrea Bandelli
- Function : Author
Burkhard Becher
- Function : Author
Matthias Becker
- Function : Author
- PersonId : 1006829
- ORCID : 0000-0002-6732-5411
Niko Beerenwinkel
- Function : Author
Monsef Benkirame
- Function : Author
Marc Beyer
- Function : Author
Wendy Bickmore
- Function : Author
Erik E a L Biessen
- Function : Author
Niklas Blomberg
- Function : Author
Ingmar Blumcke
- Function : Author
Bernd Bodenmiller
- Function : Author
Barbara Borroni
- Function : Author
Dimitrios T Boumpas
- Function : Author
Thomas Bourgeron
- Function : Author
- PersonId : 747963
- IdHAL : thomas-bourgeron
- ORCID : 0000-0001-8164-9220
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Sarion Bowers
- Function : Author
Dries Braeken
- Function : Author
Catherine Brooksbank
- Function : Author
Nils Brose
- Function : Author
Hilgo Bruining
- Function : Author
Jo Bury
- Function : Author
Nicolo Caporale
- Function : Author
Giorgio Cattoretti
- Function : Author
Nadia Chabane
- Function : Author
Stuart A Cook
- Function : Author
Paolo Curatolo
- Function : Author
Marien I de Jonge
- Function : Author
Bart Deplancke
- Function : Author
Bart de Strooper
- Function : Author
Peter de Witte
- Function : Author
Stefanie Dimmeler
- Function : Author
Bogdan Draganski
- Function : Author
Anna Drews
- Function : Author
Costica Dumbrava
- Function : Author
Stefan Engelhardt
- Function : Author
Thomas Gasser
- Function : Author
Evangelos J Giamarellos-Bourboulis
- Function : Author
Caroline Graff
- Function : Author
Dominic Grün
- Function : Author
Ivo Gut
- Function : Author
Oskar Hansson
- Function : Author
David C Henshall
- Function : Author
Anna Herland
- Function : Author
Peter Heutink
- Function : Author
Stephane R B Heymans
- Function : Author
Holger Heyn
- Function : Author
Meritxell Huch
- Function : Author
Inge Huitinga
- Function : Author
Paulina Jackowiak
- Function : Author
Karin R Jongsma
- Function : Author
Laurent Journot
- Function : Author
Jan Philipp Junker
- Function : Author
Shauna Katz
- Function : Author
Jeanne Kehren
- Function : Author
Stefan Kempa
- Function : Author
Paulus Kirchhof
- Function : Author
Christine Klein
- Function : Author
Natalia Koralewska
- Function : Author
Jan O Korbel
- Function : Author
Malte Kühnemund
- Function : Author
Angus I Lamond
- Function : Author
Elsa Lauwers
- Function : Author
Isabelle Le Ber
- Function : Author
Ville Leinonen
- Function : Author
Alejandro Lopez Tobon
- Function : Author
Emma Lundberg
- Function : Author
Astrid Lunkes
- Function : Author
Henrike Maatz
- Function : Author
Matthias Mann
- Function : Author
Luca Marelli
- Function : Author
Vera Matser
- Function : Author
Paul M Matthews
- Function : Author
Fatima Mechta-Grigoriou
- Function : Author
Radhika Menon
- Function : Author
Anne F Nielsen
- Function : Author
Massimiliano Pagani
- Function : Author
R Jeroen Pasterkamp
- Function : Author
Asla Pitkänen
- Function : Author
Valentin Popescu
- Function : Author
Cyril Pottier
- Function : Author
Alain Puisieux
- Function : Author
- PersonId : 772481
- ORCID : 0000-0002-9938-3798
- IdRef : 102162492
Rosa Rademakers
- Function : Author
Dory Reiling
- Function : Author
Orly Reiner
- Function : Author
Daniel Remondini
- Function : Author
Craig Ritchie
- Function : Author
Jonathan D Rohrer
- Function : Author
Antoine-Emmanuel Saliba
- Function : Author
Raquel Sanchez-Valle
- Function : Author
Amedeo Santosuosso
- Function : Author
Arnold Sauter
- Function : Author
Richard A Scheltema
- Function : Author
Philip Scheltens
- Function : Author
Herbert B Schiller
- Function : Author
Anja Schneider
- Function : Author
Philip Seibler
- Function : Author
Kelly Sheehan-Rooney
- Function : Author
David Shields
- Function : Author
Kristel Sleegers
- Function : Author
August B Smit
- Function : Author
Kenneth G C Smith
- Function : Author
Ilse Smolders
- Function : Author
Matthis Synofzik
- Function : Author
Wai Long Tam
- Function : Author
Sarah Teichmann
- Function : Author
Maria Thom
- Function : Author
Margherita Y Turco
- Function : Author
Heleen M M van Beusekom
- Function : Author
Rik Vandenberghe
- Function : Author
Silvie van den Hoecke
- Function : Author
Ibo van de Poel
- Function : Author
Andre van der Ven
- Function : Author
Julie van der Zee
- Function : Author
Jan van Lunzen
- Function : Author
Geert van Minnebruggen
- Function : Author
Alexander van Oudenaarden
- Function : Author
Wim van Paesschen
- Function : Author
John van Swieten
- Function : Author
Remko van Vught
- Function : Author
Matthijs Verhage
- Function : Author
Patrik Verstreken
- Function : Author
Carlo Emanuele Villa
- Function : Author
Jörg Vogel
- Function : Author
Christof von Kalle
- Function : Author
Jörn Walter
- Function : Author
Sarah Weckhuysen
- Function : Author
Wilko Weichert
- Function : Author
Louisa Wood
- Function : Author
Anette-Gabriele Ziegler
- Function : Author
Frauke Zipp
- Function : Author
Lavinia Alberi
- Function : Author
Stephanie Alexander
- Function : Author
Theodore Alexandrov
- Function : Author
Ernest Arenas
- Function : Author
Claudia Bagni
- Function : Author
Robert Balderas
- Function : Author
Andrea Bandelli
- Function : Author
Burkhard Becher
- Function : Author
Matthias Becker
- Function : Author
- PersonId : 1006829
- ORCID : 0000-0002-6732-5411
Niko Beerenwinkel
- Function : Author
Monsef Benkirane
- Function : Author
Marc Beyer
- Function : Author
Wendy A. Bickmore
- Function : Author
Erik E. A. L. Biessen
- Function : Author
Niklas Blomberg
- Function : Author
Ingmar Blumcke
- Function : Author
Bernd Bodenmiller
- Function : Author
Barbara Borroni
- Function : Author
Dimitrios T. Boumpas
- Function : Author
Thomas Bourgeron
- Function : Author
Sarion Bowers
- Function : Author
Dries Braeken
- Function : Author
Catherine Brooksbank
- Function : Author
Nils Brose
- Function : Author
Hilgo Bruining
- Function : Author
Jo Bury
- Function : Author
Nicolo Caporale
- Function : Author
Giorgio Cattoretti
- Function : Author
Nadia Chabane
- Function : Author
Hervé Chneiweiss
- Function : Author
Stuart A. Cook
- Function : Author
Paolo Curatolo
- Function : Author
Marien I. De Jonge
- Function : Author
Bart Deplancke
- Function : Author
Bart De Strooper
- Function : Author
Peter De Witte
- Function : Author
Stefanie Dimmeler
- Function : Author
Bogdan Draganski
- Function : Author
Anna Drews
- Function : Author
Costica Dumbrava
- Function : Author
Stefan Engelhardt
- Function : Author
Thomas Gasser
- Function : Author
Evangelos J. Giamarellos-Bourboulis
- Function : Author
Caroline Graff
- Function : Author
Dominic Grün
- Function : Author
Ivo G. Gut
- Function : Author
Oskar Hansson
- Function : Author
David C. Henshall
- Function : Author
Peter Heutink
- Function : Author
Stephane R. B. Heymans
- Function : Author
Holger Heyn
- Function : Author
Meritxell Huch
- Function : Author
Inge Huitinga
- Function : Author
Paulina Jackowiak
- Function : Author
Karin R. Jongsma
- Function : Author
Laurent Journot
- Function : Author
Jan Philipp Junker
- Function : Author
Shauna Katz
- Function : Author
Jeanne Kehren
- Function : Author
Stefan Kempa
- Function : Author
Paulus Kirchhof
- Function : Author
Christine Klein
- Function : Author
Natalia Koralewska
- Function : Author
Jan O. Korbel
- Function : Author
Malte Kühnemund
- Function : Author
Angus I. Lamond
- Function : Author
Elsa Lauwers
- Function : Author
Isabelle Le Ber
- Function : Author
Ville Leinonen
- Function : Author
Alejandro López-Tobón
- Function : Author
Emma Lundberg
- Function : Author
Astrid Lunkes
- Function : Author
Henrike Maatz
- Function : Author
Matthias Mann
- Function : Author
Luca Marelli
- Function : Author
Vera Matser
- Function : Author
Paul M. Matthews
- Function : Author
Fatima Mechta-Grigoriou
- Function : Author
Radhika Menon
- Function : Author
Anne F. Nielsen
- Function : Author
Massimiliano Pagani
- Function : Author
R. Jeroen Pasterkamp
- Function : Author
Asla Pitkänen
- Function : Author
Valentin Popescu
- Function : Author
Cyril Pottier
- Function : Author
Alain Puisieux
- Function : Author
Rosa Rademakers
- Function : Author
Dory Reiling
- Function : Author
Orly Reiner
- Function : Author
Daniel Remondini
- Function : Author
Craig Ritchie
- Function : Author
Jonathan D. Rohrer
- Function : Author
Antoine-Emmanuel Saliba
- Function : Author
Raquel Sanchez-Valle
- Function : Author
Amedeo Santosuosso
- Function : Author
Richard A. Scheltema
- Function : Author
Philip Scheltens
- Function : Author
Herbert B. Schiller
- Function : Author
Anja Schneider
- Function : Author
Philip Seibler
- Function : Author
Kelly Sheehan-Rooney
- Function : Author
David J. Shields
- Function : Author
Kristel Sleegers
- Function : Author
August B. Smit
- Function : Author
Kenneth G. C. Smith
- Function : Author
Ilse Smolders
- Function : Author
Matthis Synofzik
- Function : Author
Wai Long Tam
- Function : Author
Sarah A. Teichmann
- Function : Author
Maria Thom
- Function : Author
Margherita Y. Turco
- Function : Author
Heleen M. M. Van Beusekom
- Function : Author
Rik Vandenberghe
- Function : Author
Silvie van Den Hoecke
- Function : Author
Ibo van De Poel
- Function : Author
Andre van Der Ven
- Function : Author
Julie van Der Zee
- Function : Author
Jan Van Lunzen
- Function : Author
Geert Van Minnebruggen
- Function : Author
Alexander Van Oudenaarden
- Function : Author
Wim Van Paesschen
- Function : Author
John C. Van Swieten
- Function : Author
Remko Van Vught
- Function : Author
Matthijs Verhage
- Function : Author
Patrik Verstreken
- Function : Author
Carlo Emanuele Villa
- Function : Author
Jörg Vogel
- Function : Author
Christof Von Kalle
- Function : Author
Jörn Walter
- Function : Author
Sarah Weckhuysen
- Function : Author
Wilko Weichert
- Function : Author
Louisa Wood
- Function : Author
Anette-Gabriele Ziegler
- Function : Author
Frauke Zipp
- Function : Author
Abstract
Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.
Domains
Life Sciences [q-bio]
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s41586-020-2715-9.pdf (3.79 Mo)
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s41586-021-03287-8.pdf (737.34 Ko)
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