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Journal Articles Biochemical and Biophysical Research Communications Year : 1992

CYCLIN A IS REQUIRED IN S PHASE IN NORMAL EPITHELIAL CELL

Abstract

We have investigated cyclin A expression in a primary culture of normal rat hepatocytes and during rat liver regeneration after partial hepatectomy. In both cases, cyclin A mRNA and protein accumulate as the cells enter S phase. To investigate the potential implication of cyclin A accumulation at S phase, we microinjected anti-sense DNA constructs for cyclin A, resulting in effective inhibition of S phase entry. These effects were specific for cyclin A since anti-sense cyclin B construct had no similar effects. These results therefore, obtained in normal epithelial cells, indicate that cyclin A is involved in S phase and thus should not be only considered as a mitotic cyclin.

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Dates and versions

hal-04041245 , version 1 (22-06-2023)

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  • HAL Id : hal-04041245 , version 1

Cite

Frederique Zindy, Eugenia Lamas, Xavier Chenivesse, Joelle Sobczak, Jian Wang, et al.. CYCLIN A IS REQUIRED IN S PHASE IN NORMAL EPITHELIAL CELL. Biochemical and Biophysical Research Communications, 1992, 182 (3), pp.1144-1154. ⟨hal-04041245⟩
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