Compressibility and porosity modulate the mechanical properties of giant gas vesicles
Abstract
Significance Gas vesicles are produced in bacteria to achieve cellular buoyancy. These air-filled protein structures were the inspiration for developing a similar system to serve as contrast agents for ultrasound imaging. To characterize their mechanical properties, we study here the micropipette aspiration of giant gas vesicles formed by coating microbubbles with surface-active proteins adsorbed on their surface. We observe a variety of behaviors, such as large or remanent deformations. We extend current theoretical models of vesicle suction to compressible gas-filled systems and introduce the measurement of bubble permeability with this technique. We highlight the possibility of using engineered bubbles for echogenic applications and therapeutic techniques.
Domains
Physics [physics]
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pnas.2211509120-1 (2).pdf (5.31 Mo)
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pnas.2211509120-1 (1).pdf (5.31 Mo)
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pnas.2211509120-1.pdf (5.31 Mo)
Télécharger le fichier
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