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Journal Articles Small Year : 2008

Nanomosaic Network for the Detection of Proteins Without Direct Electrical Contact

Abstract

A nanomosaic network of metallic nanoparticles for the detection of ultralow concentrations of proteins is reported, which uses two planar microelectrodes embedded in a microchip that permit generation of capacitive coupling to the nanomosaic system without the need for direct electrical contact with the channel. By tailoring the microchannel surface using a sandwich configuration of polyethylene terephthalate/gold nanoparticles/poly(L-lysine), the surface charge can be modified following biomolecular interactions and monitored using a noncontact admittance technique. This nanodevice system behaves like a tunable capacitor and can be employed for the detection of any kind of molecule. The femtomolar detection of an anionic protein, such as β-lactoglobulin in phosphate-buffered saline medium, is taken as an example.

Dates and versions

hal-04136423 , version 1 (21-06-2023)

Identifiers

Cite

Jean Gamby, Jean-Pierre Abid, Bernard Tribollet, Hubert Girault. Nanomosaic Network for the Detection of Proteins Without Direct Electrical Contact. Small, 2008, 4 (6), pp.802-809. ⟨10.1002/smll.200700778⟩. ⟨hal-04136423⟩
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