Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function - Sorbonne Université Access content directly
Journal Articles Science Year : 2022

Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function

Wonyul Jang
Dmytro Puchkov
Paula Samsó
Yongtian Liang
Michal Nadler-Holly
  • Function : Author
Stephan Sigrist
Ulrich Kintscher
Fan Liu
Volker Haucke

Abstract

Cells respond to fluctuating nutrient supply by adaptive changes in organelle dynamics and in metabolism. How such changes are orchestrated on a cell-wide scale is unknown. We show that endosomal signaling lipid turnover by MTM1, a phosphatidylinositol 3-phosphate [PI(3)P] 3-phosphatase mutated in X-linked centronuclear myopathy in humans, controls mitochondrial morphology and function by reshaping the endoplasmic reticulum (ER). Starvation-induced endosomal recruitment of MTM1 impairs PI(3)P-dependent contact formation between tubular ER membranes and early endosomes, resulting in the conversion of ER tubules into sheets, the inhibition of mitochondrial fission, and sustained oxidative metabolism. Our results unravel an important role for early endosomal lipid signaling in controlling ER shape and, thereby, mitochondrial form and function to enable cells to adapt to fluctuating nutrient environments.
No file

Dates and versions

hal-04253777 , version 1 (23-10-2023)

Identifiers

Cite

Wonyul Jang, Dmytro Puchkov, Paula Samsó, Yongtian Liang, Michal Nadler-Holly, et al.. Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function. Science, 2022, 378 (6625), ⟨10.1126/science.abq5209⟩. ⟨hal-04253777⟩
13 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More