Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study) - Sorbonne Université Access content directly
Journal Articles Nutrients Year : 2019

Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study)

Kelly Giudici (1) , Sophie Guyonnet (1, 2) , Yves Rolland (2, 1) , Bruno Vellas (2, 1) , Philipe de Souto Barreto (1, 2) , Fati Nourhashemi (2, 1) , Bruno Vellas , Sophie Guyonnet , Isabelle Carrié , Lauréane Brigitte , Catherine Faisant , Françoise Lala , Julien Delrieu , Hélène Villars , Emeline Combrouze , Carole Badufle , Audrey Zueras , Sandrine Andrieu , Christelle Cantet , Christophe Morin , Gabor Abellan Van Kan , Charlotte Dupuy , Yves Rolland , Céline Caillaud , Pierre-Jean Ousset , Françoise Lala , Sherry Willis , Sylvie Belleville , Brigitte Gilbert , Francine Fontaine , Jean-François Dartigues , Isabelle Marcet , Fleur Delva , Alexandra Foubert , Sandrine Cerda , Corinne Costes , Olivier Rouaud , Patrick Manckoundia , Valérie Quipourt , Sophie Marilier , Evelyne Franon , Lawrence Bories , Marie-Laure Pader , Marie-France Basset , Bruno Lapoujade , Valérie Faure , Michael Li Yung Tong , Christine Malick-Loiseau , Evelyne Cazaban-Campistron , Françoise Desclaux , Colette Blatge , Thierry Dantoine , Cécile Laubarie-Mouret , Isabelle Saulnier , Jean-Pierre Clément , Marie-Agnès Picat , Laurence Bernard-Bourzeix , Stéphanie Willebois , Iléana Désormais , Pierre Livet , Pascale Rebaudet , Claire Gédéon , Catherine Burdet , Flavien Terracol , Alain Pesce , Stéphanie Roth , Sylvie Chaillou , Sandrine Louchart , Kristelle Sudres , Nicolas Lebrun , Karim Bennys , Audrey Gabelle , Aurélia Romano , Lynda Touati , Cécilia Marelli , Franck Le Duff , Claire Gervais , Sébastien Gonfrier , Yannick Gasnier , Serge Bordes , Danièle Begorre , Christian Carpuat , Khaled Khales , Jean-François Lefebvre , Samira Misbah El Idrissi , Pierre Skolil , Jean-Pierre Salles , Carole Dufouil , Stéphane Lehéricy (3) , Marie Chupin , Jean-François Mangin , Françoise Hugon , Fabrice Bonneville , Christophe Cognard , François Chollet , Pierre Payoux , Thierry Voisin , Julien Delrieu , Sophie Peiffer , Anne Hitzel , Michèle Allard , Michel Zanca , Jacques Monteil , Jacques Darcourt , Laurent Molinier , Hélène Derumeaux , Nadège Costa , Bertrand Perret , Claire Vinel , Sylvie Caspar-Bauguil , Pascale Olivier-Abbal , Sandrine Andrieu , Christelle Cantet , Nicola Coley
Kelly Giudici
  • Function : Author
Bruno Vellas
  • Function : Author
Sophie Guyonnet
  • Function : Author
Isabelle Carrié
  • Function : Author
Lauréane Brigitte
  • Function : Author
Catherine Faisant
  • Function : Author
Françoise Lala
  • Function : Author
Julien Delrieu
  • Function : Author
Hélène Villars
  • Function : Author
Emeline Combrouze
  • Function : Author
Carole Badufle
  • Function : Author
Audrey Zueras
  • Function : Author
Sandrine Andrieu
  • Function : Author
Christelle Cantet
  • Function : Author
Christophe Morin
  • Function : Author
Gabor Abellan Van Kan
  • Function : Author
Charlotte Dupuy
  • Function : Author
Yves Rolland
  • Function : Author
Céline Caillaud
  • Function : Author
Pierre-Jean Ousset
  • Function : Author
Françoise Lala
  • Function : Author
Sherry Willis
  • Function : Author
Sylvie Belleville
  • Function : Author
Brigitte Gilbert
  • Function : Author
Francine Fontaine
  • Function : Author
Jean-François Dartigues
  • Function : Author
Isabelle Marcet
  • Function : Author
Fleur Delva
  • Function : Author
Alexandra Foubert
  • Function : Author
Sandrine Cerda
  • Function : Author
Corinne Costes
  • Function : Author
Olivier Rouaud
  • Function : Author
Patrick Manckoundia
  • Function : Author
Valérie Quipourt
  • Function : Author
Sophie Marilier
  • Function : Author
Evelyne Franon
  • Function : Author
Lawrence Bories
  • Function : Author
Marie-Laure Pader
  • Function : Author
Marie-France Basset
  • Function : Author
Bruno Lapoujade
  • Function : Author
Valérie Faure
  • Function : Author
Michael Li Yung Tong
  • Function : Author
Christine Malick-Loiseau
  • Function : Author
Evelyne Cazaban-Campistron
  • Function : Author
Françoise Desclaux
  • Function : Author
Colette Blatge
  • Function : Author
Thierry Dantoine
  • Function : Author
Cécile Laubarie-Mouret
  • Function : Author
Isabelle Saulnier
  • Function : Author
Jean-Pierre Clément
  • Function : Author
Marie-Agnès Picat
  • Function : Author
Laurence Bernard-Bourzeix
  • Function : Author
Stéphanie Willebois
  • Function : Author
Iléana Désormais
  • Function : Author
Pierre Livet
  • Function : Author
Pascale Rebaudet
  • Function : Author
Claire Gédéon
  • Function : Author
Catherine Burdet
  • Function : Author
Flavien Terracol
  • Function : Author
Alain Pesce
  • Function : Author
Stéphanie Roth
  • Function : Author
Sylvie Chaillou
  • Function : Author
Sandrine Louchart
  • Function : Author
Kristelle Sudres
  • Function : Author
Nicolas Lebrun
  • Function : Author
Karim Bennys
  • Function : Author
Audrey Gabelle
  • Function : Author
Aurélia Romano
  • Function : Author
Lynda Touati
  • Function : Author
Cécilia Marelli
  • Function : Author
Franck Le Duff
  • Function : Author
Claire Gervais
  • Function : Author
Sébastien Gonfrier
  • Function : Author
Yannick Gasnier
  • Function : Author
Serge Bordes
  • Function : Author
Danièle Begorre
  • Function : Author
Christian Carpuat
  • Function : Author
Khaled Khales
  • Function : Author
Jean-François Lefebvre
  • Function : Author
Samira Misbah El Idrissi
  • Function : Author
Pierre Skolil
  • Function : Author
Jean-Pierre Salles
  • Function : Author
Carole Dufouil
  • Function : Author
Marie Chupin
  • Function : Author
Jean-François Mangin
  • Function : Author
Françoise Hugon
  • Function : Author
Fabrice Bonneville
  • Function : Author
Christophe Cognard
  • Function : Author
François Chollet
  • Function : Author
Pierre Payoux
Thierry Voisin
  • Function : Author
Julien Delrieu
  • Function : Author
Sophie Peiffer
  • Function : Author
Anne Hitzel
  • Function : Author
Michèle Allard
  • Function : Author
Michel Zanca
  • Function : Author
Jacques Monteil
  • Function : Author
Jacques Darcourt
  • Function : Author
Laurent Molinier
  • Function : Author
Hélène Derumeaux
  • Function : Author
Nadège Costa
  • Function : Author
Bertrand Perret
  • Function : Author
Claire Vinel
  • Function : Author
Sylvie Caspar-Bauguil
  • Function : Author
Pascale Olivier-Abbal
  • Function : Author
Sandrine Andrieu
  • Function : Author
Christelle Cantet
  • Function : Author
Nicola Coley
  • Function : Author

Abstract

This study aimed to analyze associations between weight variation patterns and changes in cognitive function and hippocampal volume among non-demented, community-dwelling elderly. Sample was formed of 1394 adults >70 years (63.9% female), all volunteers from the Multidomain Alzheimer Preventive Trial (MAPT). Weight loss was defined as ≥5% of body weight decrease in the first year of follow-up; weight gain as ≥5% of weight increase; and stability if <5% weight variation. Cognition was examined by a Z-score combining four tests. Measures were assessed at baseline, 6, 12, 24, 36, 48, and 60 months of follow-up. Hippocampal volume was evaluated with magnetic resonance imaging in 349 subjects in the first year and at 36 months. Mixed models were performed. From the 1394 participants, 5.5% (n = 76) presented weight loss, and 9.0% (n = 125) presented weight gain. Cognitive Z-score decreased among all groups after 5 years, but decline was more pronounced among those who presented weight loss (adjusted between-group mean difference vs. stable: −0.24, 95%CI: −0.41 to −0.07; p = 0.006). After 3 years, hippocampal atrophy was observed among all groups, but no between-group differences were found. In conclusion, weight loss ≥5% in the first year predicted higher cognitive decline over a 5 year follow-up among community-dwelling elderly, independently of body mass index.
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hal-04434631 , version 1 (02-02-2024)

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Kelly Giudici, Sophie Guyonnet, Yves Rolland, Bruno Vellas, Philipe de Souto Barreto, et al.. Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study). Nutrients, 2019, 11 (6), pp.1371. ⟨10.3390/nu11061371⟩. ⟨hal-04434631⟩
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