Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study)

Kelly Giudici; Sophie Guyonnet; Yves Rolland; Bruno Vellas; Philipe de Souto Barreto; Fati Nourhashemi; Bruno Vellas; Sophie Guyonnet; Isabelle Carrié; Lauréane Brigitte; Catherine Faisant; Françoise Lala; Julien Delrieu; Hélène Villars; Emeline Combrouze; Carole Badufle; Audrey Zueras; Sandrine Andrieu; Christelle Cantet; Christophe Morin; Gabor Abellan Van Kan; Charlotte Dupuy; Yves Rolland; Céline Caillaud; Pierre-Jean Ousset; Françoise Lala; Sherry Willis; Sylvie Belleville; Brigitte Gilbert; Francine Fontaine; Jean-François Dartigues; Isabelle Marcet; Fleur Delva; Alexandra Foubert; Sandrine Cerda; Corinne Costes; Olivier Rouaud; Patrick Manckoundia; Valérie Quipourt; Sophie Marilier; Evelyne Franon; Lawrence Bories; Marie-Laure Pader; Marie-France Basset; Bruno Lapoujade; Valérie Faure; Michael Li Yung Tong; Christine Malick-Loiseau; Evelyne Cazaban-Campistron; Françoise Desclaux; Colette Blatge; Thierry Dantoine; Cécile Laubarie-Mouret; Isabelle Saulnier; Jean-Pierre Clément; Marie-Agnès Picat; Laurence Bernard-Bourzeix; Stéphanie Willebois; Iléana Désormais; Pierre Livet; Pascale Rebaudet; Claire Gédéon; Catherine Burdet; Flavien Terracol; Alain Pesce; Stéphanie Roth; Sylvie Chaillou; Sandrine Louchart; Kristelle Sudres; Nicolas Lebrun; Karim Bennys; Audrey Gabelle; Aurélia Romano; Lynda Touati; Cécilia Marelli; Franck Le Duff; Claire Gervais; Sébastien Gonfrier; Yannick Gasnier; Serge Bordes; Danièle Begorre; Christian Carpuat; Khaled Khales; Jean-François Lefebvre; Samira Misbah El Idrissi; Pierre Skolil; Jean-Pierre Salles; Carole Dufouil; Stéphane Lehéricy; Marie Chupin; Jean-François Mangin; Françoise Hugon; Fabrice Bonneville; Christophe Cognard; François Chollet; Pierre Payoux; Thierry Voisin; Julien Delrieu; Sophie Peiffer; Anne Hitzel; Michèle Allard; Michel Zanca; Jacques Monteil; Jacques Darcourt; Laurent Molinier; Hélène Derumeaux; Nadège Costa; Bertrand Perret; Claire Vinel; Sylvie Caspar-Bauguil; Pascale Olivier-Abbal; Sandrine Andrieu; Christelle Cantet; Nicola Coley

doi:10.3390/nu11061371

Journal Articles Nutrients Year : 2019

Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study)

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1
2
3

Kelly Giudici

Function : Author

Gérontopôle

Sophie Guyonnet

Function : Author
PersonId : 911148
ORCID : 0000-0001-9527-5282

Gérontopôle

Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps

Yves Rolland

Function : Author
PersonId : 946609
ORCID : 0000-0002-1157-0215

Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps

Gérontopôle

Bruno Vellas

Function : Author
PersonId : 933362
ORCID : 0000-0002-7678-5065
IdRef : 03566729X

Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps

Gérontopôle

Philipe de Souto Barreto

Function : Author

Gérontopôle

Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps

Fati Nourhashemi

Function : Author
PersonId : 1346258

Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps

Gérontopôle

Bruno Vellas

Function : Author

Sophie Guyonnet

Function : Author

Isabelle Carrié

Function : Author

Lauréane Brigitte

Function : Author

Catherine Faisant

Function : Author

Françoise Lala

Function : Author

Julien Delrieu

Function : Author

Hélène Villars

Function : Author

Emeline Combrouze

Function : Author

Carole Badufle

Function : Author

Audrey Zueras

Function : Author

Sandrine Andrieu

Function : Author

Christelle Cantet

Function : Author

Christophe Morin

Function : Author

Gabor Abellan Van Kan

Function : Author

Charlotte Dupuy

Function : Author

Yves Rolland

Function : Author

Céline Caillaud

Function : Author

Pierre-Jean Ousset

Function : Author

Françoise Lala

Function : Author

Sherry Willis

Function : Author

Sylvie Belleville

Function : Author

Brigitte Gilbert

Function : Author
PersonId : 1236595
ORCID : 0000-0001-7182-9914
IdRef : 081235380

Francine Fontaine

Function : Author

Jean-François Dartigues

Function : Author

Isabelle Marcet

Function : Author

Fleur Delva

Function : Author

Alexandra Foubert

Function : Author

Sandrine Cerda

Function : Author

Corinne Costes

Function : Author

Olivier Rouaud

Function : Author

Patrick Manckoundia

Function : Author

Valérie Quipourt

Function : Author

Sophie Marilier

Function : Author

Evelyne Franon

Function : Author

Lawrence Bories

Function : Author

Marie-Laure Pader

Function : Author

Marie-France Basset

Function : Author

Bruno Lapoujade

Function : Author

Valérie Faure

Function : Author

Michael Li Yung Tong

Function : Author

Christine Malick-Loiseau

Function : Author

Evelyne Cazaban-Campistron

Function : Author

Françoise Desclaux

Function : Author

Colette Blatge

Function : Author

Thierry Dantoine

Function : Author

Cécile Laubarie-Mouret

Function : Author

Isabelle Saulnier

Function : Author

Jean-Pierre Clément

Function : Author

Marie-Agnès Picat

Function : Author

Laurence Bernard-Bourzeix

Function : Author

Stéphanie Willebois

Function : Author

Iléana Désormais

Function : Author

Pierre Livet

Function : Author

Pascale Rebaudet

Function : Author

Claire Gédéon

Function : Author

Catherine Burdet

Function : Author

Flavien Terracol

Function : Author

Alain Pesce

Function : Author

Stéphanie Roth

Function : Author

Sylvie Chaillou

Function : Author

Sandrine Louchart

Function : Author

Kristelle Sudres

Function : Author

Nicolas Lebrun

Function : Author
PersonId : 1326826

Karim Bennys

Function : Author

Audrey Gabelle

Function : Author

Aurélia Romano

Function : Author

Lynda Touati

Function : Author

Cécilia Marelli

Function : Author

Franck Le Duff

Function : Author

Claire Gervais

Function : Author

Sébastien Gonfrier

Function : Author

Yannick Gasnier

Function : Author

Serge Bordes

Function : Author

Danièle Begorre

Function : Author

Christian Carpuat

Function : Author

Khaled Khales

Function : Author

Jean-François Lefebvre

Function : Author

Samira Misbah El Idrissi

Function : Author

Pierre Skolil

Function : Author

Jean-Pierre Salles

Function : Author

Carole Dufouil

Function : Author

Stéphane Lehéricy

Function : Author
PersonId : 1288251
ORCID : 0000-0002-5802-3518
IdRef : 089427513

Institut du Cerveau = Paris Brain Institute

Marie Chupin

Function : Author
PersonId : 998763
IdRef : 084144300

Jean-François Mangin

Function : Author

Françoise Hugon

Function : Author

Fabrice Bonneville

Function : Author

Christophe Cognard

Function : Author

François Chollet

Function : Author

Pierre Payoux

Function : Author
PersonId : 173132
IdHAL : pierre-payoux
ORCID : 0000-0002-1374-1620
IdRef : 094640149

Thierry Voisin

Function : Author

Julien Delrieu

Function : Author

Sophie Peiffer

Function : Author

Anne Hitzel

Function : Author

Michèle Allard

Function : Author

Michel Zanca

Function : Author
PersonId : 993108
IdRef : 03338553X

Jacques Monteil

Function : Author

Jacques Darcourt

Function : Author

Laurent Molinier

Function : Author

Hélène Derumeaux

Function : Author

Nadège Costa

Function : Author

Bertrand Perret

Function : Author

Claire Vinel

Function : Author

Sylvie Caspar-Bauguil

Function : Author

Pascale Olivier-Abbal

Function : Author

Sandrine Andrieu

Function : Author

Christelle Cantet

Function : Author

Nicola Coley

Function : Author

Abstract

This study aimed to analyze associations between weight variation patterns and changes in cognitive function and hippocampal volume among non-demented, community-dwelling elderly. Sample was formed of 1394 adults >70 years (63.9% female), all volunteers from the Multidomain Alzheimer Preventive Trial (MAPT). Weight loss was defined as ≥5% of body weight decrease in the first year of follow-up; weight gain as ≥5% of weight increase; and stability if <5% weight variation. Cognition was examined by a Z-score combining four tests. Measures were assessed at baseline, 6, 12, 24, 36, 48, and 60 months of follow-up. Hippocampal volume was evaluated with magnetic resonance imaging in 349 subjects in the first year and at 36 months. Mixed models were performed. From the 1394 participants, 5.5% (n = 76) presented weight loss, and 9.0% (n = 125) presented weight gain. Cognitive Z-score decreased among all groups after 5 years, but decline was more pronounced among those who presented weight loss (adjusted between-group mean difference vs. stable: −0.24, 95%CI: −0.41 to −0.07; p = 0.006). After 3 years, hippocampal atrophy was observed among all groups, but no between-group differences were found. In conclusion, weight loss ≥5% in the first year predicted higher cognitive decline over a 5 year follow-up among community-dwelling elderly, independently of body mass index.

Keywords

cognition weight loss aging hippocampal atrophy elderly Alzheimer's disease

Domains

Human health and pathology

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nutrients-11-01371.pdf (253.52 Ko)

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https://hal.sorbonne-universite.fr/hal-04434631

Submitted on : Friday, February 2, 2024-2:00:38 PM

Last modification on : Wednesday, December 11, 2024-9:56:57 AM

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hal-04434631 , version 1 (02-02-2024)

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HAL Id : hal-04434631 , version 1
DOI : 10.3390/nu11061371
PUBMED : 31216732
PUBMEDCENTRAL : PMC6627683

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Kelly Giudici, Sophie Guyonnet, Yves Rolland, Bruno Vellas, Philipe de Souto Barreto, et al.. Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study). Nutrients, 2019, 11 (6), pp.1371. ⟨10.3390/nu11061371⟩. ⟨hal-04434631⟩

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Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study)

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