Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation
Antoine Beurnier
(1, 2, 3)
,
Etienne-Marie Jutant
(4)
,
Mitja Jevnikar
(3, 2, 5)
,
Athénaïs Boucly
(3)
,
Jérémie Pichon
(6, 1, 2)
,
Mariana Preda
,
Marie Frank
(7)
,
Jérémy Laurent
(8)
,
Christian Richard
(2, 3)
,
Xavier Monnet
(2, 3)
,
Jacques Duranteau
(2)
,
Anatole Harrois
(9, 3)
,
Marie-Camille Chaumais
(1, 10, 3)
,
Marie-France Bellin
(11, 2)
,
Nicolas Noël
(2, 12, 13, 14)
,
Sophie Bulifon
(6, 1, 2)
,
Xavier Jaïs
(3, 2, 5)
,
Florence Parent
(15, 16)
,
Andrei Seferian
(3)
,
Laurent Savale
(3, 2, 5)
,
Olivier Sitbon
(3)
,
David Montani
(3)
,
Marc Humbert
(3)
1
Université Paris-Saclay
2 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
3 HPPIT - Hypertension pulmonaire : physiopathologie et innovation thérapeutique
4 CHU Tenon [AP-HP]
5 Hôpital Marie-Lannelongue
6 HPPIT - Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique
7 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
8 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
9 Service d'anesthésie-réanimation, reanimation chirurgicale
10 Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pharmacie, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France
11 BIOMAPS - LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay
12 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
13 IMETI - Institut des Maladies Emergentes et des Thérapies Innovantes
14 IDMIT - Infectious Diseases Models for Innovative Therapies
15 Inrap, Marseille - Institut national de recherches archéologiques préventives - Centre de recherches archéologiques de Marseille
16 LA3M - Laboratoire d'Archéologie Médiévale et Moderne en Méditerranée
2 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
3 HPPIT - Hypertension pulmonaire : physiopathologie et innovation thérapeutique
4 CHU Tenon [AP-HP]
5 Hôpital Marie-Lannelongue
6 HPPIT - Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique
7 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
8 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
9 Service d'anesthésie-réanimation, reanimation chirurgicale
10 Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pharmacie, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France
11 BIOMAPS - LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay
12 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
13 IMETI - Institut des Maladies Emergentes et des Thérapies Innovantes
14 IDMIT - Infectious Diseases Models for Innovative Therapies
15 Inrap, Marseille - Institut national de recherches archéologiques préventives - Centre de recherches archéologiques de Marseille
16 LA3M - Laboratoire d'Archéologie Médiévale et Moderne en Méditerranée
Mariana Preda
- Fonction : Auteur
Laurent Savale
- Fonction : Auteur
- PersonId : 761036
- ORCID : 0000-0002-6862-8975
- IdRef : 098817345
Olivier Sitbon
- Fonction : Auteur
- PersonId : 763553
- ORCID : 0000-0002-1942-1951
- IdRef : 081152221
David Montani
- Fonction : Auteur
- PersonId : 765451
- ORCID : 0000-0002-9358-6922
- IdRef : 092632580
Marc Humbert
- Fonction : Auteur
- PersonId : 756837
- ORCID : 0000-0003-0703-2892
- IdRef : 071559426
Résumé
Background Viral respiratory infections are the main causes of asthma exacerbation. The susceptibility of asthmatics to develop an exacerbation when they present with severe pneumonia due to SARS-CoV-2 infection is unknown. The objective of this study was to investigate the characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who required hospitalisation during the spring 2020 outbreak in Paris, France. Methods A prospective cohort follow-up was carried out from March 15 to April 15, 2020 in Bicêtre Hospital, University Paris-Saclay, France. All hospitalised patients with a SARS-CoV-2 infection who reported a history of asthma were included. Results Among 768 hospitalised patients, 37 (4.8%) reported a history of asthma, which had been previously confirmed by a pulmonologist in 85% of cases. Patients were mainly female (70%), non-smokers (85%), with a median age of 54 years (interquartile range, IQR 42–67). None of them presented with an asthma exacerbation. Twenty-two (59%) had major comorbidities and 31 (84%) had a body mass index ≥25 kg·m −2 . The most common comorbidities were obesity (36%), hypertension (27%) and diabetes (19%). All patients had a confirmed diagnosis of COVID-19 pneumonia on computed tomography of the chest. Eosinopenia was a typical biologic feature with a median count of 0/mm3 (IQR 0–0). Eleven patients (30%) were admitted in intensive care unit with three death (8.1%) occurring in the context of comorbidities. Conclusion Asthmatics were not overrepresented among patients with severe pneumonia due to SARS-CoV-2 infection who required hospitalisation. Worst outcomes were observed mainly in patients with major comorbidities.