The Benson Complex Figure Test detects deficits in visuoconstruction and visual memory in symptomatic familial frontotemporal dementia: A GENFI study

Lize C Jiskoot; Lucy L Russell; Georgia Peakman; Rhian S Convery; Caroline V Greaves; Martina Bocchetta; Jackie M Poos; Harro Seelaar; Lucia A.A. Giannini; John C van Swieten; Rick van Minkelen; Yolande A.L. Pijnenburg; James B Rowe; Barbara Borroni; Daniela Galimberti; Mario Masellis; Carmela Tartaglia; Elizabeth Finger; Chris R Butler; Caroline Graff; Robert Laforce; Raquel Sanchez-Valle; Alexandre de Mendonça; Fermin Moreno; Matthis Synofzik; Rik Vandenberghe; Simon Ducharme; Isabelle Le Ber; Johannes Levin; Markus Otto; Florence Pasquier; Isabel Santana; David M Cash; David Thomas; Jonathan D Rohrer; Arabella Bouzigues; Martin N. Rossor; Nick C. Fox; Jason D. Warren; Imogen J. Swift; Rachelle Shafei; Carolin Heller; Emily Todd; Ione Woollacott; Henrik Zetterberg; Annabel Nelson; Rita Guerreiro; Jose Bras; David L. Thomas; Simon Mead Phd; Alina Díez Msc; Ekaterina Rogaeva; Morris Freedman; Ron Keren; David Tang-Wai; Hakan Thonberg; Linn Öijerstedt; Christin Andersson; Vesna Jelic; Andrea Arighi; Chiara Fenoglio; Elio Scarpini; Giorgio Fumagalli; Thomas Cope; Carolyn Timberlake; Timothy Rittman; Christen Shoesmith; Robart Bartha; Rosa Rademakers; Carlo Wilke; Hans-Otto Karnarth; Benjamin Bender; Rose Bruffaerts; Philip Vandamme; Mathieu Vandenbulcke; Catarina B. Ferreira; Gabriel Miltenberger; Carolina Maruta; Ana Verdelho; Sónia Afonso; Ricardo Taipa; Paola Caroppo; Giuseppe Di Fede; Giorgio Giaccone; Sara Prioni; Veronica Redaelli; Giacomina Rossi; Pietro Tiraboschi; Diana Duro; Maria Rosario Almeida; Miguel Castelo-Branco; Maria João Leitão; Miguel Tabuas-Pereira; Beatriz Santiago; Serge Gauthier; Pedro Rosa-Neto; Michele Veldsman; Paul Thompson; Tobias Langheinrich; Catharina Prix; Tobias Hoegen; Elisabeth Wlasich; Sandra Loosli; Sonja Schonecker; Sarah Anderl-Straub; Jolina Lombardi; Nuria Bargalló; Alberto Benussi; Valentina Cantoni; Maxime Bertoux; Anne Bertrand; Alexis Brice; Agnès Camuzat; Olivier Colliot; Sabrina Sayah; Aurélie Funkiewiez; Daisy Rinaldi; Gemma Lombardi; Benedetta Nacmias; Dario Saracino; Valentina Bessi; Camilla Ferrari; Marta Cañada; Vincent Deramecourt; Gregory Kuchcinski; Thibaud Lebouvier; Cristina Polito; Adeline Rollin

doi:10.1016/j.jns.2023.120590

Journal Articles Journal of the Neurological Sciences Year : 2023

The Benson Complex Figure Test detects deficits in visuoconstruction and visual memory in symptomatic familial frontotemporal dementia: A GENFI study

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Lize C Jiskoot

Function : Author
PersonId : 1370397

Erasmus University Medical Center [Rotterdam]

Lucy L Russell

Function : Author
PersonId : 1364153

Dementia Research Centre [London]

Georgia Peakman

Function : Author
PersonId : 1370398

Dementia Research Centre [London]

Rhian S Convery

Function : Author
PersonId : 1370399

Dementia Research Centre [London]

Caroline V Greaves

Function : Author
PersonId : 1370400

Dementia Research Centre [London]

Martina Bocchetta

Function : Author
PersonId : 1363148
ORCID : 0000-0003-1814-5024

Dementia Research Centre [London]

Jackie M Poos

Function : Author
PersonId : 1370401

Erasmus University Medical Center [Rotterdam]

Harro Seelaar

Function : Author
PersonId : 889978

Erasmus University Medical Center [Rotterdam]

Lucia A.A. Giannini

Function : Author

Erasmus University Medical Center [Rotterdam]

John C van Swieten

Function : Author
PersonId : 1370402

Erasmus University Medical Center [Rotterdam]

Rick van Minkelen

Function : Author
PersonId : 906947

Erasmus University Medical Center [Rotterdam]

Yolande A.L. Pijnenburg

Function : Author

James B Rowe

Function : Author
PersonId : 887931

University of Cambridge [UK]

Barbara Borroni

Function : Author

Università degli Studi di Brescia = University of Brescia

Daniela Galimberti

Function : Author
PersonId : 908451

Centro Dino Ferrari [Milano]

Mario Masellis

Function : Author
PersonId : 1370403

Sunnybrook Research Institute [Toronto]

Carmela Tartaglia

Function : Author
PersonId : 1370404

University of Toronto

Elizabeth Finger

Function : Author
PersonId : 1370405

University of Western Ontario

Chris R Butler

Function : Author
PersonId : 954619

University of Oxford

Caroline Graff

Function : Author
PersonId : 889097

Karolinska University Hospital [Stockholm]

Robert Laforce

Function : Author
PersonId : 1370406

Université Laval [Québec]

Raquel Sanchez-Valle

Function : Author

Institut d'Investigacions Biomèdiques August Pi i Sunyer

Alexandre de Mendonça

Function : Author

Universidade de Lisboa = University of Lisbon = Université de Lisbonne

Fermin Moreno

Function : Author

Matthis Synofzik

Function : Author
PersonId : 887987

Universitätsklinikum Tübingen - University Hospital of Tübingen

Rik Vandenberghe

Function : Author
PersonId : 921848

Catholic University of Leuven = Katholieke Universiteit Leuven

Simon Ducharme

Function : Author
PersonId : 1368613

McGill University Health Center [Montreal]

Isabelle Le Ber

Function : Author
PersonId : 889822

Institut du Cerveau = Paris Brain Institute

Johannes Levin

Function : Author
PersonId : 1370407

Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München

Markus Otto

Function : Author
PersonId : 1370408

Universitätsklinikum Ulm - University Hospital of Ulm

Florence Pasquier

Function : Author

Equipe Alzheimer and Tauopathies - LilNCog

Isabel Santana

Function : Author

University of Coimbra [Portugal]

David M Cash

Function : Author
PersonId : 1370409

Dementia Research Centre [London]

David Thomas

Function : Author
PersonId : 1370410

Dementia Research Centre [London]

Jonathan D Rohrer

Function : Author
PersonId : 1110171
ORCID : 0000-0002-6155-8417

Dementia Research Centre [London]

Arabella Bouzigues

Function : Author

Martin N. Rossor

Function : Author

Nick C. Fox

Function : Author

Jason D. Warren

Function : Author

Imogen J. Swift

Function : Author

Rachelle Shafei

Function : Author

Carolin Heller

Function : Author

Emily Todd

Function : Author

Ione Woollacott

Function : Author

Henrik Zetterberg

Function : Author

Annabel Nelson

Function : Author

Rita Guerreiro

Function : Author

Jose Bras

Function : Author

David L. Thomas

Function : Author

Simon Mead Phd

Function : Author

Alina Díez Msc

Function : Author

Ekaterina Rogaeva

Function : Author

Morris Freedman

Function : Author

Ron Keren

Function : Author

David Tang-Wai

Function : Author

Hakan Thonberg

Function : Author

Linn Öijerstedt

Function : Author

Christin Andersson

Function : Author

Vesna Jelic

Function : Author

Andrea Arighi

Function : Author

Chiara Fenoglio

Function : Author

Elio Scarpini

Function : Author

Giorgio Fumagalli

Function : Author

Thomas Cope

Function : Author

Carolyn Timberlake

Function : Author

Timothy Rittman

Function : Author

Christen Shoesmith

Function : Author

Robart Bartha

Function : Author

Rosa Rademakers

Function : Author

Carlo Wilke

Function : Author

Hans-Otto Karnarth

Function : Author

Benjamin Bender

Function : Author

Rose Bruffaerts

Function : Author

Philip Vandamme

Function : Author

Mathieu Vandenbulcke

Function : Author

Catarina B. Ferreira

Function : Author

Gabriel Miltenberger

Function : Author

Carolina Maruta

Function : Author

Ana Verdelho

Function : Author

Sónia Afonso

Function : Author

Ricardo Taipa

Function : Author

Paola Caroppo

Function : Author

Giuseppe Di Fede

Function : Author

Giorgio Giaccone

Function : Author

Sara Prioni

Function : Author

Veronica Redaelli

Function : Author

Giacomina Rossi

Function : Author

Pietro Tiraboschi

Function : Author

Diana Duro

Function : Author

Maria Rosario Almeida

Function : Author

Miguel Castelo-Branco

Function : Author

Maria João Leitão

Function : Author

Miguel Tabuas-Pereira

Function : Author

Beatriz Santiago

Function : Author

Serge Gauthier

Function : Author

Pedro Rosa-Neto

Function : Author

Michele Veldsman

Function : Author

Paul Thompson

Function : Author

Tobias Langheinrich

Function : Author

Catharina Prix

Function : Author

Tobias Hoegen

Function : Author

Elisabeth Wlasich

Function : Author

Sandra Loosli

Function : Author

Sonja Schonecker

Function : Author

Sarah Anderl-Straub

Function : Author

Jolina Lombardi

Function : Author

Nuria Bargalló

Function : Author

Alberto Benussi

Function : Author

Valentina Cantoni

Function : Author

Maxime Bertoux

Function : Author

Anne Bertrand

Function : Author

Institut du Cerveau = Paris Brain Institute

Alexis Brice

Function : Author
PersonId : 1104774
ORCID : 0000-0002-0941-3990
IdRef : 050512935

Institut du Cerveau = Paris Brain Institute

Agnès Camuzat

Function : Author

Institut du Cerveau = Paris Brain Institute

Olivier Colliot

Function : Author

Institut du Cerveau = Paris Brain Institute

Sabrina Sayah

Function : Author

Institut du Cerveau = Paris Brain Institute

Aurélie Funkiewiez

Function : Author

Institut du Cerveau = Paris Brain Institute

Daisy Rinaldi

Function : Author

Institut du Cerveau = Paris Brain Institute

Gemma Lombardi

Function : Author

CHU Pitié-Salpêtrière [AP-HP]

Benedetta Nacmias

Function : Author

CHU Pitié-Salpêtrière [AP-HP]

Dario Saracino

Function : Author

Institut du Cerveau = Paris Brain Institute

Valentina Bessi

Function : Author

Camilla Ferrari

Function : Author

Marta Cañada

Function : Author

Vincent Deramecourt

Function : Author

Gregory Kuchcinski

Function : Author

Thibaud Lebouvier

Function : Author
PersonId : 754049
IdHAL : thibaud-lebouvier
ORCID : 0000-0002-6630-394X
IdRef : 177112190

Cristina Polito

Function : Author

Adeline Rollin

Function : Author

Abstract

Objective: Sensitive cognitive markers are still needed for frontotemporal dementia (FTD). The Benson Complex Figure Test (BCFT) is an interesting candidate test, as it assesses visuospatial, visual memory, and executive abilities, allowing the detection of multiple mechanisms of cognitive impairment. To investigate differences in BCFT Copy, Recall and Recognition in presymptomatic and symptomatic FTD mutation carriers, and to explore its cognitive and neuroimaging correlates. Method: We included cross-sectional data from 332 presymptomatic and 136 symptomatic mutation carriers (GRN, MAPT or C9orf72 mutations), and 290 controls in the GENFI consortium. We examined gene-specific differences between mutation carriers (stratified by CDR® NACC-FTLD score) and controls using Quade’s / Pearson Х2 tests. We investigated associations with neuropsychological test scores and grey matter volume using partial correlations and multiple regression models respectively. Results: No significant differences were found between groups at CDR® NACC-FTLD 0–0.5. Symptomatic GRN and C9orf72 mutation carriers had lower Copy scores at CDR® NACC-FTLD ≥2. All three groups had lower Recall scores at CDR® NACC-FTLD ≥2, with MAPT mutation carriers starting at CDR® NACC-FTLD ≥1. All three groups had lower Recognition scores at CDR® NACC FTLD ≥2. Performance correlated with tests for visuoconstruction, memory, and executive function. Copy scores correlated with frontal-subcortical grey matter atrophy, while Recall scores correlated with temporal lobe atrophy. Conclusions: In the symptomatic stage, the BCFT identifies differential mechanisms of cognitive impairment depending on the genetic mutation, corroborated by gene-specific cognitive and neuroimaging correlates. Our findings suggest that impaired performance on the BCFT occurs relatively late in the genetic FTD disease process. Therefore its potential as cognitive biomarker for upcoming clinical trials in presymptomatic to early-stage FTD is most likely limited.

Keywords

Frontotemporal dementia Cognition Neuropsychology Genetic Presymptomatic

Domains

Neurons and Cognition [q-bio.NC]

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1-s2.0-S0022510X23000503-main.pdf (3.32 Mo)

Origin	Publication funded by an institution
Licence	Attribution - NonCommercial - NoDerivatives

Gestionnaire HAL 8 Sorbonne Université : Connect in order to contact the contributor

https://hal.sorbonne-universite.fr/hal-04530005

Submitted on : Tuesday, April 2, 2024-6:43:07 PM

Last modification on : Tuesday, July 23, 2024-4:33:04 PM

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hal-04530005 , version 1 (02-04-2024)

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Attribution - NonCommercial - NoDerivatives

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HAL Id : hal-04530005 , version 1
DOI : 10.1016/j.jns.2023.120590
PUBMED : 36812822

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Lize C Jiskoot, Lucy L Russell, Georgia Peakman, Rhian S Convery, Caroline V Greaves, et al.. The Benson Complex Figure Test detects deficits in visuoconstruction and visual memory in symptomatic familial frontotemporal dementia: A GENFI study. Journal of the Neurological Sciences, 2023, 446, pp.120590. ⟨10.1016/j.jns.2023.120590⟩. ⟨hal-04530005⟩

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The Benson Complex Figure Test detects deficits in visuoconstruction and visual memory in symptomatic familial frontotemporal dementia: A GENFI study

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