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Article Dans Une Revue Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Année : 2021

Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study

1 Erasmus MC - Erasmus University Medical Center [Rotterdam]
2 UCL Queen Square Institute of Neurology
3 Amsterdam UMC - Amsterdam University Medical Center
4 UniBs - Università degli Studi di Brescia = University of Brescia
5 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
6 University of Barcelona
7 HUD - Hospital Universitario Donostia [San Sebastian, Spain]
8 IIS Biodonostia - Biodonostia Health Research Institute [Donostia-San Sebastian, Spain]
9 CHU de Québec–Université Laval
10 Karolinska Institutet [Stockholm]
11 KUH - Karolinska University Hospital [Solna, Sweden]
12 Eberhard Karls Universität Tübingen = University of Tübingen
13 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
14 UNIMI - Università degli Studi di Milano = University of Milan
15 Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico [Milan, Italy]
16 CUH - Cambridge University Hospitals - NHS
17 CAM - University of Cambridge [UK]
18 SRI - Sunnybrook Research Institute [Toronto]
19 University of Toronto
20 Tanz Center Research in Neurodegenerative Diseases [Toronto]
21 UWO - University of Western Ontario
22 University Hospitals Leuven [Leuven]
23 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
24 LBI - Leuven Brain Institute [Leuven, Belgium]
25 ULISBOA - Universidade de Lisboa = University of Lisbon = Université de Lisbonne
26 Fondazione IRCCS Istituto Neurologico "Carlo Besta"
27 University of Oxford
28 Imperial College London
29 UC - University of Coimbra [Portugal]
30 ICM - Institut du Cerveau = Paris Brain Institute
31 CHU Pitié-Salpêtrière [AP-HP]
32 University of Manchester [Manchester]
33 Universität Duisburg-Essen = University of Duisburg-Essen [Essen]
34 Douglas Mental Health University Institute [Montréal]
35 McGill University = Université McGill [Montréal, Canada]
36 MNI - McConnell Brain Imaging Centre
37 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
38 SyNery - Munich Cluster of Systems Neurology
39 Universität Ulm - Ulm University [Ulm, Allemagne]
40 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
41 Fondazione Don Carlo Gnocchi
42 Excellence Laboratory LabEx DISTALZ
43 CNRMAJ - Centre national de référence pour les malades Alzheimer jeunes
44 U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog
45 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]

Résumé

Introduction: We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods: The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163 progranulin [GRN], and 73 microtubule-associated protein tau [MAPT]) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel-based morphometry to investigate the underlying neural substrates of the FCSRT. Results: All symptomatic mutation carrier groups and presymptomatic MAPT mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic C9orf72 group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic GRN mutation carriers. Performance on the FCSRT correlated with executive function, particularly in C9orf72 mutation carriers, but also with memory and naming tasks in the MAPT group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in C9orf72 and GRN, but mainly temporal areas in MAPT mutation carriers. Discussion: The FCSRT detects presymptomatic deficits in C9orf72- and MAPT-associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.
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hal-04538526 , version 1 (09-04-2024)

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Jackie M Poos, Lucy L Russell, Georgia Peakman, Martina Bocchetta, Caroline V Greaves, et al.. Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021, 13 (1), pp.e12185. ⟨10.1002/dad2.12185⟩. ⟨hal-04538526⟩
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