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Journal Articles Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Year : 2021

Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study

Jackie M Poos
  • Function : Author
  • PersonId : 1370401
Lucy L Russell
  • Function : Author
Georgia Peakman
  • Function : Author
Martina Bocchetta
  • Function : Author
Caroline V Greaves
  • Function : Author
Lize C Jiskoot
  • Function : Author
Emma L van der Ende
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Harro Seelaar
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Janne M Papma
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Esther van den Berg
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Yolande a L Pijnenburg
  • Function : Author
Barbara Borroni
  • Function : Author
Raquel Sanchez‐valle
  • Function : Author
Fermin Moreno
  • Function : Author
Robert Laforce
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Caroline Graff
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Matthias Synofzik
  • Function : Author
Daniela Galimberti
  • Function : Author
James B Rowe
  • Function : Author
Mario Masellis
  • Function : Author
Carmela Tartaglia
  • Function : Author
Elizabeth Finger
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Rik Vandenberghe
  • Function : Author
Alexandre de Medonça
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Fabrizio Tagliavini
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Chris R Butler
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Isabel Santana
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Alex Gerhard
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Simon Ducharme
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Johannes Levin
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Adrian Danek
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Markus Otto
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Sandro Sorbi
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John C van Swieten
  • Function : Author
Jonathan D Rohrer

Abstract

Introduction: We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods: The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163 progranulin [GRN], and 73 microtubule-associated protein tau [MAPT]) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel-based morphometry to investigate the underlying neural substrates of the FCSRT. Results: All symptomatic mutation carrier groups and presymptomatic MAPT mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic C9orf72 group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic GRN mutation carriers. Performance on the FCSRT correlated with executive function, particularly in C9orf72 mutation carriers, but also with memory and naming tasks in the MAPT group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in C9orf72 and GRN, but mainly temporal areas in MAPT mutation carriers. Discussion: The FCSRT detects presymptomatic deficits in C9orf72- and MAPT-associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.
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Dates and versions

hal-04538526 , version 1 (09-04-2024)

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Jackie M Poos, Lucy L Russell, Georgia Peakman, Martina Bocchetta, Caroline V Greaves, et al.. Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021, 13, ⟨10.1002/dad2.12185⟩. ⟨hal-04538526⟩
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