No effect of subthalamic deep brain stimulation on metacognition in Parkinson’s disease - Sorbonne Université Access content directly
Journal Articles Scientific Reports Year : 2023

No effect of subthalamic deep brain stimulation on metacognition in Parkinson’s disease

Abstract

Abstract Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a powerful treatment in Parkinson’s disease (PD), which provides a positive effect on motor symptoms although the way it operates on high cognitive processes such as metacognition remains unclear. To address this issue, we recorded electroencephalogram (EEG) of PD patients treated with STN-DBS that performed a reversal learning (RL) paradigm endowed with metacognitive self-assessment. We considered two stimulation conditions, namely DBS-ON (stimulation on) and DBS-OFF (stimulation off), and focused our EEG-analysis on the frontal brain region due to its involvement on high cognitive processes. We found a trend towards a significant difference in RL ability between stimulation conditions. STN-DBS showed no effect on metacognition, although a significant association between accuracy and decision confidence level held for DBS OFF, but not in the case of DBS ON. In summary, our study revealed no significant effect of STN-DBS on RL or metacognition.
Fichier principal
Vignette du fichier
s41598-022-26980-8.pdf (1.87 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Licence : CC BY - Attribution

Dates and versions

hal-04542376 , version 1 (11-04-2024)

Licence

Attribution

Identifiers

Cite

Carlos Trenado, Matthias Boschheidgen, Karim N’diaye, Alfons Schnitzler, Luc Mallet, et al.. No effect of subthalamic deep brain stimulation on metacognition in Parkinson’s disease. Scientific Reports, 2023, 13 (1), pp.10. ⟨10.1038/s41598-022-26980-8⟩. ⟨hal-04542376⟩
15 View
3 Download

Altmetric

Share

Gmail Facebook X LinkedIn More