Establishing the role of rare coding variants in known Parkinson's disease risk loci - Sorbonne Université Access content directly
Journal Articles Neurobiology of Aging Year : 2017

Establishing the role of rare coding variants in known Parkinson's disease risk loci

Abstract

Many common genetic factors have been identified to contribute to Parkinson's disease (PD) susceptibility, improving our understanding of the related underlying biological mechanisms. The involvement of rarer variants in these loci has been poorly studied. Using International Parkinson's Disease Genomics Consortium data sets, we performed a comprehensive study to determine the impact of rare variants in 23 previously published genome-wide association studies (GWAS) loci in PD. We applied Prix fixe to select the putative causal genes underneath the GWAS peaks, which was based on underlying functional similarities. The Sequence Kernel Association Test was used to analyze the joint effect of rare, common, or both types of variants on PD susceptibility. All genes were tested simultaneously as a gene set and each gene individually. We observed a moderate association of common variants, confirming the involvement of the known PD risk loci within our genetic data sets. Focusing on rare variants, we identified additional association signals for LRRK2, STBD1, and SPATA19. Our study suggests an involvement of rare variants within several putatively causal genes underneath previously identified PD GWAS peaks.

Dates and versions

hal-04558758 , version 1 (25-04-2024)

Identifiers

Cite

Iris Jansen, J. Raphael Gibbs, Mike Nalls, T. Ryan Price, Steven Lubbe, et al.. Establishing the role of rare coding variants in known Parkinson's disease risk loci. Neurobiology of Aging, 2017, 59, pp.220.e11-220.e18. ⟨10.1016/j.neurobiolaging.2017.07.009⟩. ⟨hal-04558758⟩
4 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More