Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium - Sorbonne Université Access content directly
Journal Articles Psychological Medicine Year : 2019

Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium

Renato Polimanti (1, 2) , Roseann Peterson (3) , Jue-Sheng Ong (4) , Stuart Macgregor (4) , Alexis Edwards (3) , Toni-Kim Clarke (5) , Josef Frank (6) , Zachary Gerring (4) , Nathan Gillespie (3) , Penelope Lind (4) , Hermine Maes (3) , Nicholas Martin (4) , Hamdi Mbarek (7) , Sarah Medland (4) , Fabian Streit (6) , Arpana Agrawal (8) , Howard Edenberg (9) , Kenneth Kendler (3) , Cathryn Lewis (10) , Patrick Sullivan (11) , Naomi Wray (12) , Joel Gelernter (1, 2) , Eske Derks (4) , Naomi R. Wray , Stephan Ripke , Manuel Mattheisen , Maciej Trzaskowski , Enda M. Byrne , Abdel Abdellaoui , Mark J. Adams , Esben Agerbo , Tracy M. Air , Till M. F. Andlauer , Silviu-Alin Bacanu , Marie Bækvad-Hansen , Aartjan F. T. Beekman , Tim B. Bigdeli , Elisabeth B. Binder , Douglas R. H. Blackwood , Julien Bryois , Henriette N. Buttenschøn , Jonas Bybjerg-Grauholm , Na Cai , Enrique Castelao , Jane Hvarregaard Christensen , Toni-Kim Clarke , Jonathan I. R. Coleman , Lucía Colodro-Conde , Baptiste Couvy-Duchesne (13) , Nick Craddock , Gregory E. Crawford , Cheynna A. Crowley , Hassan S. Dashti , Gail Davies , Ian J. Deary , Franziska Degenhardt , Eske M. Derks , Nese Direk , Conor V. Dolan , Erin C. Dunn , Thalia C. Eley , Nicholas Eriksson , Valentina Escott-Price , Farnush Hassan Farhadi Kiadeh , Hilary K. Finucane , Andreas J. Forstner , Josef Frank , Héléna A. Gaspar , Michael Gill , Paola Giusti-Rodríguez , Fernando S. Goes , Scott D. Gordon , Jakob Grove , Lynsey S. Hall , Eilis Hannon , Christine Søholm Hansen , Thomas F. Hansen , Stefan Herms , Ian B. Hickie , Per Hoffmann , Georg Homuth , Carsten Horn , Jouke-Jan Hottenga , David M. Hougaard , Ming Hu , Craig L. Hyde , Marcus Ising , Rick Jansen , Fulai Jin , Eric Jorgenson , James A. Knowles , Isaac S. Kohane , Julia Kraft , Warren W. Kretzschmar , Jesper Krogh , Zoltán Kutalik , Jacqueline M. Lane , Yihan Li , Yun Li , Penelope A. Lind , Xiaoxiao Liu , Leina Lu , Donald J. Macintyre , Dean F. Mackinnon , Robert M. Maier , Wolfgang Maier , Jonathan Marchini , Hamdi Mbarek , Patrick Mcgrath , Peter Mcguffin , Sarah E. Medland , Divya Mehta , Christel M. Middeldorp , Evelin Mihailov , Yuri Milaneschi , Lili Milani , Jonathan Mill , Francis M. Mondimore , Grant W. Montgomery , Sara Mostafavi , Niamh Mullins , Matthias Nauck , Bernard Ng , Michel G. Nivard , Dale R. Nyholt , Paul F. O’reilly , Hogni Oskarsson , Michael J. Owen , Jodie N. Painter , Carsten Bøcker Pedersen , Marianne Giørtz Pedersen , Roseann E. Peterson , Erik Pettersson , Wouter J. Peyrot , Giorgio Pistis , Danielle Posthuma , Shaun M. Purcell , Jorge A. Quiroz , Per Qvist , John P. Rice , Brien P. Riley , Margarita Rivera , Saira Saeed Mirza , Richa Saxena , Robert Schoevers , Eva C. Schulte , Ling Shen , Jianxin Shi , Stanley I. Shyn , Engilbert Sigurdsson , Grant B. C. Sinnamon , Johannes H. Smit , Daniel J. Smith , Hreinn Stefansson , Stacy Steinberg , Craig A. Stockmeier , Fabian Streit , Jana Strohmaier , Katherine E. Tansey , Henning Teismann , Alexander Teumer , Wesley Thompson , Pippa A. Thomson , Thorgeir E. Thorgeirsson , Chao Tian , Matthew Traylor , Jens Treutlein , Vassily Trubetskoy , André G. Uitterlinden , Daniel Umbricht , Sandra van Der Auwera , Albert M. Van Hemert , Alexander Viktorin , Peter M. Visscher , Yunpeng Wang , Bradley T. Webb , Shantel Marie Weinsheimer , Jürgen Wellmann , Gonneke Willemsen , Stephanie H. Witt , Yang Wu , Hualin S. Xi , Jian Yang , Futao Zhang , Volker Arolt , Bernhard T. Baune , Klaus Berger , Dorret I. Boomsma , Sven Cichon , Udo Dannlowski , E. C. J. De Geus , J. Raymond Depaulo , Enrico Domenici , Katharina Domschke , Tõnu Esko , Hans J. Grabe , Steven P. Hamilton , Caroline Hayward , Andrew C. Heath , David A. Hinds , Kenneth S. Kendler , Stefan Kloiber , Glyn Lewis , Qingqin S. Li , Susanne Lucae , Pamela F. A. Madden , Patrik K. Magnusson , Nicholas G. Martin , Andrew M. Mcintosh , Andres Metspalu , Ole Mors , Preben Bo Mortensen , Bertram Müller-Myhsok , Merete Nordentoft , Markus M. Nöthen , Michael C. O’donovan , Sara A. Paciga , Nancy L. Pedersen , Brenda W. J. H. Penninx , Roy H. Perlis , David J. Porteous , James B. Potash , Martin Preisig , Marcella Rietschel , Catherine Schaefer , Thomas G. Schulze , Jordan W. Smoller , Kari Stefansson , Henning Tiemeier , Rudolf Uher , Henry Völzke , Myrna M. Weissman , Thomas Werge , Ashley R. Winslow , Cathryn M. Lewis , Douglas F. Levinson , Gerome Breen , Anders D. Børglum , Patrick F. Sullivan , Raymond K. Walters , Renato Polimanti , Emma C. Johnson , Jeanette N. Mcclintick , Mark J. Adams , Amy E. Adkins , Fazil Aliev , Silviu-Alin Bacanu , Anthony Batzler , Sarah Bertelsen , Joanna M. Biernacka , Tim B. Bigdeli , Li-Shiun Chen , Toni-Kim Clarke , Yi-Ling Chou , Franziska Degenhardt , Anna R. Docherty , Alexis C. Edwards , Pierre Fontanillas , Jerome C. Foo , Louis Fox , Josef Frank , Ina Giegling , Scott Gordon , Laura M. Hack , Annette M. Hartmann , Sarah M. Hartz , Stefanie Heilmann-Heimbach , Stefan Herms , Colin Hodgkinson , Per Hoffmann , Jouke Jan Hottenga , Martin A. Kennedy , Mervi Alanne-Kinnunen , Bettina Konte , Jari Lahti , Marius Lahti-Pulkkinen , Dongbing Lai , Lannie Ligthart , Anu Loukola , Brion S. Maher , Hamdi Mbarek , Andrew M. Mcintosh , Matthew B. Mcqueen , Jacquelyn L. Meyers , Yuri Milaneschi , Teemu Palviainen , John F. Pearson , Roseann E. Peterson , Samuli Ripatti , Euijung Ryu , Nancy L. Saccone , Jessica E. Salvatore , Sandra Sanchez-Roige , Melanie Schwandt , Richard Sherva , Fabian Streit , Jana Strohmaier , Nathaniel Thomas , Jen-Chyong Wang , Bradley T. Webb , Robbee Wedow , Leah Wetherill , Amanda G. Wills , Jason D. Boardman , Danfeng Chen , Doo-Sup Choi , William E. Copeland , Robert C. Culverhouse , Norbert Dahmen , Louisa Degenhardt , Benjamin W. Domingue , Sarah L. Elson , Mark A. Frye , Wolfgang Gäbel , Caroline Hayward , Marcus Ising , Margaret Keyes , Falk Kiefer , John Kramer , Samuel Kuperman , Susanne Lucae , Michael T. Lynskey , Wolfgang Maier , Karl Mann , Satu Männistö , Bertram Müller-Myhsok , Alison D. Murray , John I. Nurnberger , Aarno Palotie , Ulrich Preuss , Katri Räikkönen , Maureen D Reynolds , Monika Ridinger , Norbert Scherbaum , Marc A. Schuckit , Michael Soyka , Jens Treutlein , Stephanie Witt , Norbert Wodarz , Peter Zill , Daniel E. Adkins , Joseph M. Boden , Dorret I. Boomsma , Laura J. Bierut , Sandra A. Brown , Kathleen K. Bucholz , Sven Cichon , E. Jane Costello , Harriet De Wit , Nancy Diazgranados , Danielle M. Dick , Johan G. Eriksson , Lindsay A. Farrer , Tatiana M. Foroud , Nathan Gillespie , Alison M. Goate , David Goldman , Richard A. Grucza , Dana Hancock , Kathleen Mullan Harris , Andrew C. Heath , Victor Hesselbrock , John K. Hewitt , Christian J. Hopfer , John Horwood , William Iacono , Eric O. Johnson , Jaakko A. Kaprio , Victor M. Karpyak , Kenneth S. Kendler , Henry R. Kranzler , Kenneth Krauter , Paul Lichtenstein , Penelope A. Lind , Matt Mcgue , James Mackillop , Pamela A. F. Madden , Hermine H. Maes , Patrik Magnusson , Nicholas G. Martin , Sarah E. Medland , Grant W. Montgomery , Elliot C. Nelson , Markus M. Nöthen , Abraham A. Palmer , Nancy L. Pedersen , Brenda W. J. H. Penninx , Bernice Porjesz , John P. Rice , Marcella Rietschel , Brien P. Riley , Richard Rose , Dan Rujescu , Pei-Hong Shen , Judy Silberg , Michael C. Stallings , Ralph E. Tarter , Michael M. Vanyukov , Scott Vrieze , Tamara L. Wall , John B. Whitfield , Hongyu Zhao , Benjamin M. Neale , Joel Gelernter , Howard J. Edenberg , Arpana Agrawal , Michelle Agee , Babak Alipanahi , Adam Auton , Robert K. Bell , Katarzyna Bryc , Sarah L. Elson , Pierre Fontanillas , Nicholas A. Furlotte , David A. Hinds , Karen E. Huber , Aaron Kleinman , Nadia K. Litterman , Matthew H. Mcintyre , Joanna L. Mountain , Elizabeth S. Noblin , Carrie A.M. Northover , Steven J. Pitts , J. Fah Sathirapongsasuti , Olga V. Sazonova , Janie F. Shelton , Suyash Shringarpure , Chao Tian , Joyce Y. Tung , Vladimir Vacic , Catherine H. Wilson
Naomi R. Wray
  • Function : Author
Stephan Ripke
  • Function : Author
Manuel Mattheisen
  • Function : Author
Maciej Trzaskowski
  • Function : Author
Enda M. Byrne
  • Function : Author
Abdel Abdellaoui
  • Function : Author
Mark J. Adams
  • Function : Author
Esben Agerbo
  • Function : Author
Tracy M. Air
  • Function : Author
Till M. F. Andlauer
  • Function : Author
Silviu-Alin Bacanu
  • Function : Author
Marie Bækvad-Hansen
  • Function : Author
Aartjan F. T. Beekman
  • Function : Author
Tim B. Bigdeli
  • Function : Author
Elisabeth B. Binder
  • Function : Author
Douglas R. H. Blackwood
  • Function : Author
Julien Bryois
  • Function : Author
Henriette N. Buttenschøn
  • Function : Author
Jonas Bybjerg-Grauholm
  • Function : Author
Na Cai
  • Function : Author
Enrique Castelao
  • Function : Author
Jane Hvarregaard Christensen
  • Function : Author
Toni-Kim Clarke
  • Function : Author
Jonathan I. R. Coleman
  • Function : Author
Lucía Colodro-Conde
  • Function : Author
Nick Craddock
  • Function : Author
Gregory E. Crawford
  • Function : Author
Cheynna A. Crowley
  • Function : Author
Hassan S. Dashti
  • Function : Author
Gail Davies
  • Function : Author
Ian J. Deary
  • Function : Author
Franziska Degenhardt
  • Function : Author
Eske M. Derks
  • Function : Author
Nese Direk
  • Function : Author
Conor V. Dolan
  • Function : Author
Erin C. Dunn
  • Function : Author
Thalia C. Eley
  • Function : Author
Nicholas Eriksson
  • Function : Author
Valentina Escott-Price
  • Function : Author
Farnush Hassan Farhadi Kiadeh
  • Function : Author
Hilary K. Finucane
  • Function : Author
Andreas J. Forstner
  • Function : Author
Josef Frank
  • Function : Author
Héléna A. Gaspar
  • Function : Author
Michael Gill
  • Function : Author
Paola Giusti-Rodríguez
  • Function : Author
Fernando S. Goes
  • Function : Author
Scott D. Gordon
  • Function : Author
Jakob Grove
  • Function : Author
Lynsey S. Hall
  • Function : Author
Eilis Hannon
  • Function : Author
Christine Søholm Hansen
  • Function : Author
Thomas F. Hansen
  • Function : Author
Stefan Herms
  • Function : Author
Ian B. Hickie
  • Function : Author
Per Hoffmann
  • Function : Author
Georg Homuth
  • Function : Author
Carsten Horn
  • Function : Author
Jouke-Jan Hottenga
  • Function : Author
David M. Hougaard
  • Function : Author
Ming Hu
  • Function : Author
Craig L. Hyde
  • Function : Author
Marcus Ising
  • Function : Author
Rick Jansen
  • Function : Author
Fulai Jin
  • Function : Author
Eric Jorgenson
  • Function : Author
James A. Knowles
  • Function : Author
Isaac S. Kohane
  • Function : Author
Julia Kraft
  • Function : Author
Warren W. Kretzschmar
  • Function : Author
Jesper Krogh
  • Function : Author
Zoltán Kutalik
  • Function : Author
Jacqueline M. Lane
  • Function : Author
Yihan Li
  • Function : Author
Yun Li
  • Function : Author
Penelope A. Lind
  • Function : Author
Xiaoxiao Liu
  • Function : Author
Leina Lu
  • Function : Author
Donald J. Macintyre
  • Function : Author
Dean F. Mackinnon
  • Function : Author
Robert M. Maier
  • Function : Author
Wolfgang Maier
  • Function : Author
Jonathan Marchini
  • Function : Author
Hamdi Mbarek
  • Function : Author
Patrick Mcgrath
  • Function : Author
Peter Mcguffin
  • Function : Author
Sarah E. Medland
  • Function : Author
Divya Mehta
  • Function : Author
Christel M. Middeldorp
  • Function : Author
Evelin Mihailov
  • Function : Author
Yuri Milaneschi
  • Function : Author
Lili Milani
  • Function : Author
Jonathan Mill
  • Function : Author
Francis M. Mondimore
  • Function : Author
Grant W. Montgomery
  • Function : Author
Sara Mostafavi
  • Function : Author
Niamh Mullins
  • Function : Author
Matthias Nauck
  • Function : Author
Bernard Ng
  • Function : Author
Michel G. Nivard
  • Function : Author
Dale R. Nyholt
  • Function : Author
Paul F. O’reilly
  • Function : Author
Hogni Oskarsson
  • Function : Author
Michael J. Owen
  • Function : Author
Jodie N. Painter
  • Function : Author
Carsten Bøcker Pedersen
  • Function : Author
Marianne Giørtz Pedersen
  • Function : Author
Roseann E. Peterson
  • Function : Author
Erik Pettersson
  • Function : Author
Wouter J. Peyrot
  • Function : Author
Giorgio Pistis
  • Function : Author
Danielle Posthuma
  • Function : Author
Shaun M. Purcell
  • Function : Author
Jorge A. Quiroz
  • Function : Author
Per Qvist
  • Function : Author
John P. Rice
  • Function : Author
Brien P. Riley
  • Function : Author
Margarita Rivera
  • Function : Author
Saira Saeed Mirza
  • Function : Author
Richa Saxena
  • Function : Author
Robert Schoevers
  • Function : Author
Eva C. Schulte
  • Function : Author
Ling Shen
  • Function : Author
Jianxin Shi
  • Function : Author
Stanley I. Shyn
  • Function : Author
Engilbert Sigurdsson
  • Function : Author
Grant B. C. Sinnamon
  • Function : Author
Johannes H. Smit
  • Function : Author
Daniel J. Smith
  • Function : Author
Hreinn Stefansson
  • Function : Author
Stacy Steinberg
  • Function : Author
Craig A. Stockmeier
  • Function : Author
Fabian Streit
  • Function : Author
Jana Strohmaier
  • Function : Author
Katherine E. Tansey
  • Function : Author
Henning Teismann
  • Function : Author
Alexander Teumer
  • Function : Author
Wesley Thompson
  • Function : Author
Pippa A. Thomson
  • Function : Author
Thorgeir E. Thorgeirsson
  • Function : Author
Chao Tian
  • Function : Author
Matthew Traylor
  • Function : Author
Jens Treutlein
  • Function : Author
Vassily Trubetskoy
  • Function : Author
André G. Uitterlinden
  • Function : Author
Daniel Umbricht
  • Function : Author
Sandra van Der Auwera
  • Function : Author
Albert M. Van Hemert
  • Function : Author
Alexander Viktorin
  • Function : Author
Peter M. Visscher
  • Function : Author
Yunpeng Wang
  • Function : Author
Bradley T. Webb
  • Function : Author
Shantel Marie Weinsheimer
  • Function : Author
Jürgen Wellmann
  • Function : Author
Gonneke Willemsen
  • Function : Author
Stephanie H. Witt
  • Function : Author
Yang Wu
  • Function : Author
Hualin S. Xi
  • Function : Author
Jian Yang
  • Function : Author
Futao Zhang
  • Function : Author
Volker Arolt
  • Function : Author
Bernhard T. Baune
  • Function : Author
Klaus Berger
  • Function : Author
Dorret I. Boomsma
  • Function : Author
Sven Cichon
  • Function : Author
Udo Dannlowski
  • Function : Author
E. C. J. De Geus
  • Function : Author
J. Raymond Depaulo
  • Function : Author
Enrico Domenici
  • Function : Author
Katharina Domschke
  • Function : Author
Tõnu Esko
  • Function : Author
Hans J. Grabe
  • Function : Author
Steven P. Hamilton
  • Function : Author
Caroline Hayward
  • Function : Author
Andrew C. Heath
  • Function : Author
David A. Hinds
  • Function : Author
Kenneth S. Kendler
  • Function : Author
Stefan Kloiber
  • Function : Author
Glyn Lewis
  • Function : Author
Qingqin S. Li
  • Function : Author
Susanne Lucae
  • Function : Author
Pamela F. A. Madden
  • Function : Author
Patrik K. Magnusson
  • Function : Author
Nicholas G. Martin
  • Function : Author
Andrew M. Mcintosh
  • Function : Author
Andres Metspalu
  • Function : Author
Ole Mors
  • Function : Author
Preben Bo Mortensen
  • Function : Author
Bertram Müller-Myhsok
  • Function : Author
Merete Nordentoft
  • Function : Author
Markus M. Nöthen
  • Function : Author
Michael C. O’donovan
  • Function : Author
Sara A. Paciga
  • Function : Author
Nancy L. Pedersen
  • Function : Author
Brenda W. J. H. Penninx
  • Function : Author
Roy H. Perlis
  • Function : Author
David J. Porteous
  • Function : Author
James B. Potash
  • Function : Author
Martin Preisig
  • Function : Author
Marcella Rietschel
  • Function : Author
Catherine Schaefer
  • Function : Author
Thomas G. Schulze
  • Function : Author
Jordan W. Smoller
  • Function : Author
Kari Stefansson
  • Function : Author
Henning Tiemeier
  • Function : Author
Rudolf Uher
  • Function : Author
Henry Völzke
  • Function : Author
Myrna M. Weissman
  • Function : Author
Thomas Werge
  • Function : Author
Ashley R. Winslow
  • Function : Author
Cathryn M. Lewis
  • Function : Author
Douglas F. Levinson
  • Function : Author
Gerome Breen
  • Function : Author
Anders D. Børglum
  • Function : Author
Patrick F. Sullivan
  • Function : Author
Raymond K. Walters
  • Function : Author
Renato Polimanti
  • Function : Author
Emma C. Johnson
  • Function : Author
Jeanette N. Mcclintick
  • Function : Author
Mark J. Adams
  • Function : Author
Amy E. Adkins
  • Function : Author
Fazil Aliev
  • Function : Author
Silviu-Alin Bacanu
  • Function : Author
Anthony Batzler
  • Function : Author
Sarah Bertelsen
  • Function : Author
Joanna M. Biernacka
  • Function : Author
Tim B. Bigdeli
  • Function : Author
Li-Shiun Chen
  • Function : Author
Toni-Kim Clarke
  • Function : Author
Yi-Ling Chou
  • Function : Author
Franziska Degenhardt
  • Function : Author
Anna R. Docherty
  • Function : Author
Alexis C. Edwards
  • Function : Author
Pierre Fontanillas
  • Function : Author
Jerome C. Foo
  • Function : Author
Louis Fox
  • Function : Author
Josef Frank
  • Function : Author
Ina Giegling
  • Function : Author
Scott Gordon
  • Function : Author
Laura M. Hack
  • Function : Author
Annette M. Hartmann
  • Function : Author
Sarah M. Hartz
  • Function : Author
Stefanie Heilmann-Heimbach
  • Function : Author
Stefan Herms
  • Function : Author
Colin Hodgkinson
  • Function : Author
Per Hoffmann
  • Function : Author
Jouke Jan Hottenga
  • Function : Author
Martin A. Kennedy
  • Function : Author
Mervi Alanne-Kinnunen
  • Function : Author
Bettina Konte
  • Function : Author
Jari Lahti
  • Function : Author
Marius Lahti-Pulkkinen
  • Function : Author
Dongbing Lai
  • Function : Author
Lannie Ligthart
  • Function : Author
Anu Loukola
  • Function : Author
Brion S. Maher
  • Function : Author
Hamdi Mbarek
  • Function : Author
Andrew M. Mcintosh
  • Function : Author
Matthew B. Mcqueen
  • Function : Author
Jacquelyn L. Meyers
  • Function : Author
Yuri Milaneschi
  • Function : Author
Teemu Palviainen
  • Function : Author
John F. Pearson
  • Function : Author
Roseann E. Peterson
  • Function : Author
Samuli Ripatti
  • Function : Author
Euijung Ryu
  • Function : Author
Nancy L. Saccone
  • Function : Author
Jessica E. Salvatore
  • Function : Author
Sandra Sanchez-Roige
  • Function : Author
Melanie Schwandt
  • Function : Author
Richard Sherva
  • Function : Author
Fabian Streit
  • Function : Author
Jana Strohmaier
  • Function : Author
Nathaniel Thomas
  • Function : Author
Jen-Chyong Wang
  • Function : Author
Bradley T. Webb
  • Function : Author
Robbee Wedow
  • Function : Author
Leah Wetherill
  • Function : Author
Amanda G. Wills
  • Function : Author
Jason D. Boardman
  • Function : Author
Danfeng Chen
  • Function : Author
Doo-Sup Choi
  • Function : Author
William E. Copeland
  • Function : Author
Robert C. Culverhouse
  • Function : Author
Norbert Dahmen
  • Function : Author
Louisa Degenhardt
  • Function : Author
Benjamin W. Domingue
  • Function : Author
Sarah L. Elson
  • Function : Author
Mark A. Frye
  • Function : Author
Wolfgang Gäbel
  • Function : Author
Caroline Hayward
  • Function : Author
Marcus Ising
  • Function : Author
Margaret Keyes
  • Function : Author
Falk Kiefer
  • Function : Author
John Kramer
  • Function : Author
Samuel Kuperman
  • Function : Author
Susanne Lucae
  • Function : Author
Michael T. Lynskey
  • Function : Author
Wolfgang Maier
  • Function : Author
Karl Mann
  • Function : Author
Satu Männistö
  • Function : Author
Bertram Müller-Myhsok
  • Function : Author
Alison D. Murray
  • Function : Author
John I. Nurnberger
  • Function : Author
Aarno Palotie
  • Function : Author
Ulrich Preuss
  • Function : Author
Katri Räikkönen
  • Function : Author
Maureen D Reynolds
  • Function : Author
Monika Ridinger
  • Function : Author
Norbert Scherbaum
  • Function : Author
Marc A. Schuckit
  • Function : Author
Michael Soyka
  • Function : Author
Jens Treutlein
  • Function : Author
Stephanie Witt
  • Function : Author
Norbert Wodarz
  • Function : Author
Peter Zill
  • Function : Author
Daniel E. Adkins
  • Function : Author
Joseph M. Boden
  • Function : Author
Dorret I. Boomsma
  • Function : Author
Laura J. Bierut
  • Function : Author
Sandra A. Brown
  • Function : Author
Kathleen K. Bucholz
  • Function : Author
Sven Cichon
  • Function : Author
E. Jane Costello
  • Function : Author
Harriet De Wit
  • Function : Author
Nancy Diazgranados
  • Function : Author
Danielle M. Dick
  • Function : Author
Johan G. Eriksson
  • Function : Author
Lindsay A. Farrer
  • Function : Author
Tatiana M. Foroud
  • Function : Author
Nathan Gillespie
  • Function : Author
Alison M. Goate
  • Function : Author
David Goldman
  • Function : Author
Richard A. Grucza
  • Function : Author
Dana Hancock
  • Function : Author
Kathleen Mullan Harris
  • Function : Author
Andrew C. Heath
  • Function : Author
Victor Hesselbrock
  • Function : Author
John K. Hewitt
  • Function : Author
Christian J. Hopfer
  • Function : Author
John Horwood
  • Function : Author
William Iacono
  • Function : Author
Eric O. Johnson
  • Function : Author
Jaakko A. Kaprio
  • Function : Author
Victor M. Karpyak
  • Function : Author
Kenneth S. Kendler
  • Function : Author
Henry R. Kranzler
  • Function : Author
Kenneth Krauter
  • Function : Author
Paul Lichtenstein
  • Function : Author
Penelope A. Lind
  • Function : Author
Matt Mcgue
  • Function : Author
James Mackillop
  • Function : Author
Pamela A. F. Madden
  • Function : Author
Hermine H. Maes
  • Function : Author
Patrik Magnusson
  • Function : Author
Nicholas G. Martin
  • Function : Author
Sarah E. Medland
  • Function : Author
Grant W. Montgomery
  • Function : Author
Elliot C. Nelson
  • Function : Author
Markus M. Nöthen
  • Function : Author
Abraham A. Palmer
  • Function : Author
Nancy L. Pedersen
  • Function : Author
Brenda W. J. H. Penninx
  • Function : Author
Bernice Porjesz
  • Function : Author
John P. Rice
  • Function : Author
Marcella Rietschel
  • Function : Author
Brien P. Riley
  • Function : Author
Richard Rose
  • Function : Author
Dan Rujescu
  • Function : Author
Pei-Hong Shen
  • Function : Author
Judy Silberg
  • Function : Author
Michael C. Stallings
  • Function : Author
Ralph E. Tarter
  • Function : Author
Michael M. Vanyukov
  • Function : Author
Scott Vrieze
  • Function : Author
Tamara L. Wall
  • Function : Author
John B. Whitfield
  • Function : Author
Hongyu Zhao
  • Function : Author
Benjamin M. Neale
  • Function : Author
Joel Gelernter
  • Function : Author
Howard J. Edenberg
  • Function : Author
Arpana Agrawal
  • Function : Author
Michelle Agee
  • Function : Author
Babak Alipanahi
  • Function : Author
Adam Auton
  • Function : Author
Robert K. Bell
  • Function : Author
Katarzyna Bryc
  • Function : Author
Sarah L. Elson
  • Function : Author
Pierre Fontanillas
  • Function : Author
Nicholas A. Furlotte
  • Function : Author
David A. Hinds
  • Function : Author
Karen E. Huber
  • Function : Author
Aaron Kleinman
  • Function : Author
Nadia K. Litterman
  • Function : Author
Matthew H. Mcintyre
  • Function : Author
Joanna L. Mountain
  • Function : Author
Elizabeth S. Noblin
  • Function : Author
Carrie A.M. Northover
  • Function : Author
Steven J. Pitts
  • Function : Author
J. Fah Sathirapongsasuti
  • Function : Author
Olga V. Sazonova
  • Function : Author
Janie F. Shelton
  • Function : Author
Suyash Shringarpure
  • Function : Author
Chao Tian
  • Function : Author
Joyce Y. Tung
  • Function : Author
Vladimir Vacic
  • Function : Author
Catherine H. Wilson
  • Function : Author

Abstract

Background: Despite established clinical associations among major depression (MD), alcohol dependence (AD), and alcohol consumption (AC), the nature of the causal relationship between them is not completely understood. We leveraged genome-wide data from the Psychiatric Genomics Consortium (PGC) and UK Biobank to test for the presence of shared genetic mechanisms and causal relationships among MD, AD, and AC. Methods: Linkage disequilibrium score regression and Mendelian randomization (MR) were performed using genome-wide data from the PGC (MD: 135 458 cases and 344 901 controls; AD: 10 206 cases and 28 480 controls) and UK Biobank (AC-frequency: 438 308 individuals; AC-quantity: 307 098 individuals). Results: Positive genetic correlation was observed between MD and AD (rgMD-AD = + 0.47, P = 6.6 × 10-10). AC-quantity showed positive genetic correlation with both AD (rgAD-AC quantity = + 0.75, P = 1.8 × 10-14) and MD (rgMD-AC quantity = + 0.14, P = 2.9 × 10-7), while there was negative correlation of AC-frequency with MD (rgMD-AC frequency = -0.17, P = 1.5 × 10-10) and a non-significant result with AD. MR analyses confirmed the presence of pleiotropy among these four traits. However, the MD-AD results reflect a mediated-pleiotropy mechanism (i.e. causal relationship) with an effect of MD on AD (beta = 0.28, P = 1.29 × 10-6). There was no evidence for reverse causation. Conclusion: This study supports a causal role for genetic liability of MD on AD based on genetic datasets including thousands of individuals. Understanding mechanisms underlying MD-AD comorbidity addresses important public health concerns and has the potential to facilitate prevention and intervention efforts.

Dates and versions

hal-04562439 , version 1 (29-04-2024)

Identifiers

Cite

Renato Polimanti, Roseann Peterson, Jue-Sheng Ong, Stuart Macgregor, Alexis Edwards, et al.. Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. Psychological Medicine, 2019, 49 (07), pp.1218-1226. ⟨10.1017/S0033291719000667⟩. ⟨hal-04562439⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More