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Journal Articles Neurology Year : 2021

Dystonia and Tremor

Aasef Shaikh
  • Function : Author
Sinem Balta Beylergil
Laura Scorr
  • Function : Author
Gamze Kilic-Berkmen
  • Function : Author
Alan Freeman
  • Function : Author
Christine Klein
  • Function : Author
Johanna Junker
  • Function : Author
Sebastian Loens
  • Function : Author
Norbert Brüggemann
  • Function : Author
Alexander Münchau
  • Function : Author
Tobias Bäumer
  • Function : Author
Cecilia Bonnet
  • Function : Author
Joseph Jankovic
  • Function : Author
Joohi Jimenez-Shahed
  • Function : Author
Neepa Patel
  • Function : Author
Laura Marsh
  • Function : Author
Cynthia Comella
  • Function : Author
Richard Barbano
  • Function : Author
Brian Berman
Irene Malaty
  • Function : Author
Aparna Wagle Shukla
  • Function : Author
Stephen Reich
  • Function : Author
Mark Ledoux
  • Function : Author
Alfredo Berardelli
  • Function : Author
Gina Ferrazzano
  • Function : Author
Natividad Stover
  • Function : Author
William Ondo
  • Function : Author
Sarah Pirio Richardson
  • Function : Author
Rachel Saunders-Pullman
  • Function : Author
Zoltan Mari
  • Function : Author
Pinky Agarwal
  • Function : Author
Charles Adler
  • Function : Author
Sylvain Chouinard
  • Function : Author
Susan Fox
  • Function : Author
Allison Brashear
Daniel Truong
  • Function : Author
Oksana Suchowersky
  • Function : Author
Samuel Frank
  • Function : Author
Stewart Factor
  • Function : Author
Joel Perlmutter
  • Function : Author
Hyder Azad Jinnah
  • Function : Author

Abstract

Objective To assess the clinical manifestations and predictors of different types of tremors in individuals with different types of isolated dystonia. Methods Clinical manifestations of tremor were assessed in a multicenter, international cross-sectional, cohort study of 2,362 individuals with all types of isolated dystonia (focal, segmental, multifocal, and generalized) recruited through the Dystonia Coalition. Results Methodical and standardized assessments of all participants in this cohort revealed the overall prevalence of any type of tremor was 53.3%. The prevalence of dystonic tremor varied from 36.9% to 48.4%, depending on criteria used to define it. To identify the factors associated with tremors in dystonia, the data were analyzed by generalized linear modeling and cluster analyses. Generalized linear modeling indicated 2 of the strongest factors associated with tremor included body region affected by dystonia and recruitment center. Tremor was also associated with severity of dystonia and duration of dystonia, but not with sex or race. The cluster analysis distinguished 8 subgroups within the whole cohort; defined largely by body region with dystonia, and secondarily by other clinical characteristics. Conclusion The large number of cases evaluated by an international team of movement disorder experts facilitated the dissection of several important factors that influence the apparent prevalence and phenomenology of tremor in dystonia. These results are valuable for understanding the many differences reported in prior studies, and for guiding future studies of the nosology of tremor and dystonia.

Dates and versions

hal-04566336 , version 1 (02-05-2024)

Identifiers

Cite

Aasef Shaikh, Sinem Balta Beylergil, Laura Scorr, Gamze Kilic-Berkmen, Alan Freeman, et al.. Dystonia and Tremor: A Cross-Sectional Study of the Dystonia Coalition Cohort. Neurology, 2021, 96 (4), ⟨10.1212/WNL.0000000000011049⟩. ⟨hal-04566336⟩
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