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Journal Articles Movement Disorders Year : 2020

Differences in the Presentation and Progression of Parkinson's Disease by Sex

Hirotaka Iwaki
Cornelis Blauwendraat
  • Function : Author
Hampton Leonard
  • Function : Author
Mary Makarious
  • Function : Author
Jonggeol Kim
  • Function : Author
Ganqiang Liu
Jodi Maple-Grødem
  • Function : Author
Lasse Pihlstrøm
  • Function : Author
Marlies van Nimwegen
  • Function : Author
Luba Smolensky
  • Function : Author
Ninad Amondikar
  • Function : Author
Samantha Hutten
  • Function : Author
Mark Frasier
  • Function : Author
Khanh‐dung Nguyen
  • Function : Author
Jacqueline Rick
  • Function : Author
Shirley Eberly
  • Function : Author
Faraz Faghri
  • Function : Author
Peggy Auinger
  • Function : Author
Kirsten Scott
  • Function : Author
Ruwani Wijeyekoon
  • Function : Author
Vivianna van Deerlin
  • Function : Author
Dena Hernandez
  • Function : Author
Raphael Gibbs
  • Function : Author
Aaron Day-Williams
  • Function : Author
Guido Alves
  • Function : Author
Alastair Noyce
Ole‐bjørn Tysnes
  • Function : Author
Jonathan Evans
  • Function : Author
David Breen
  • Function : Author
Karol Estrada
  • Function : Author
Claire Wegel
  • Function : Author
David Simon
  • Function : Author
Ole Andreassen
  • Function : Author
Bernard Ravina
  • Function : Author
Mathias Toft
  • Function : Author
Peter Heutink
  • Function : Author
Bastiaan Bloem
  • Function : Author
Daniel Weintraub
Roger Barker
  • Function : Author
Caroline Williams-Gray
Bart van de Warrenburg
  • Function : Author
Jacobus van Hilten
  • Function : Author
Clemens Scherzer
  • Function : Author
Andrew Singleton
  • Function : Author
Mike Nalls
  • Function : Author

Abstract

ABSTRACT Background Previous studies reported various symptoms of Parkinson's disease (PD) associated with sex. Some were conflicting or confirmed in only one study. Objectives We examined sex associations to PD phenotypes cross‐sectionally and longitudinally in large‐scale data. Methods We tested 40 clinical phenotypes, using longitudinal, clinic‐based patient cohorts, consisting of 5946 patients, with a median follow‐up of 3.1 years. For continuous outcomes, we used linear regressions at baseline to test sex‐associated differences in presentation, and linear mixed‐effects models to test sex‐associated differences in progression. For binomial outcomes, we used logistic regression models at baseline and Cox regression models for survival analyses. We adjusted for age, disease duration, and medication use. In the secondary analyses, data from 17 719 PD patients and 7588 non‐PD participants from an online‐only, self‐assessment PD cohort were cross‐sectionally evaluated to determine whether the sex‐associated differences identified in the primary analyses were consistent and unique to PD. Results Female PD patients had a higher risk of developing dyskinesia early during the follow‐up period, with a slower progression in activities of daily living difficulties, and a lower risk of developing cognitive impairments compared with male patients. The findings in the longitudinal, clinic‐based cohorts were mostly consistent with the results of the online‐only cohort. Conclusions We observed sex‐associated contributions to PD heterogeneity. These results highlight the necessity of future research to determine the underlying mechanisms and importance of personalized clinical management. © 2020 International Parkinson and Movement Disorder Society

Dates and versions

hal-04566391 , version 1 (02-05-2024)

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Hirotaka Iwaki, Cornelis Blauwendraat, Hampton Leonard, Mary Makarious, Jonggeol Kim, et al.. Differences in the Presentation and Progression of Parkinson's Disease by Sex. Movement Disorders, 2020, 36 (1), pp.106-117. ⟨10.1002/mds.28312⟩. ⟨hal-04566391⟩
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