Clinical and Demographic Characteristics of Upper Limb Dystonia - Sorbonne Université Access content directly
Journal Articles Movement Disorders Year : 2020

Clinical and Demographic Characteristics of Upper Limb Dystonia

Scott Norris
Hyder Jinnah
  • Function : Author
Christine Klein
  • Function : Author
Joseph Jankovic
  • Function : Author
Brian Berman
Abhimanyu Mahajan
  • Function : Author
Alberto Espay
Avinash Murthy
  • Function : Author
Victor S.C. Fung
  • Function : Author
Mark Ledoux
  • Function : Author
Florence C.F. Chang
  • Function : Author
Claudia Testa
  • Function : Author
Richard Barbano
  • Function : Author
Irene Malaty
Tobias Bäumer
  • Function : Author
Sebastian Loens
  • Function : Author
Laura Wright
  • Function : Author
Joel Perlmutter
  • Function : Author

Abstract

ABSTRACT Background Knowledge of characteristics in upper limb dystonia remains limited, derived primarily from small, single‐site studies. Objective The objective of this study was to characterize demographic and clinical characteristics of upper limb dystonia from the Dystonia Coalition data set, a large, international, multicenter resource. Methods We evaluated clinical and demographic characteristics of 367 participants with upper limb dystonia from onset, comparing across subcategories of focal (with and without dystonia spread) versus nonfocal onset. Results Focal onset occurred in 80%; 67% remained focal without spread. Task specificity was most frequent in this subgroup, most often writer's cramp and affecting the dominant limb (83%). Focal onset with spread was more frequent in young onset (<21 years). Focal onset occurred equally in women and men; nonfocal onset affected women disproportionately. Conclusions Upper limb dystonia distribution, focality, and task specificity relate to onset age and likelihood of regional spread. Observations may inform clinical counseling and design, execution, and interpretation of future studies. © 2020 International Parkinson and Movement Disorder Society.

Dates and versions

hal-04571072 , version 1 (07-05-2024)

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Scott Norris, Hyder Jinnah, Christine Klein, Joseph Jankovic, Brian Berman, et al.. Clinical and Demographic Characteristics of Upper Limb Dystonia. Movement Disorders, 2020, 35 (11), pp.2086-2090. ⟨10.1002/mds.28223⟩. ⟨hal-04571072⟩
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