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Article Dans Une Revue Movement Disorders Année : 2020

Clinical and Demographic Characteristics of Upper Limb Dystonia

Scott Norris
Hyder Jinnah
  • Fonction : Auteur
Christine Klein
  • Fonction : Auteur
Joseph Jankovic
  • Fonction : Auteur
Brian Berman
Abhimanyu Mahajan
  • Fonction : Auteur
Alberto Espay
Avinash Murthy
  • Fonction : Auteur
Victor S.C. Fung
  • Fonction : Auteur
Mark Ledoux
  • Fonction : Auteur
Florence C.F. Chang
  • Fonction : Auteur
Claudia Testa
  • Fonction : Auteur
Richard Barbano
  • Fonction : Auteur
Irene Malaty
Tobias Bäumer
  • Fonction : Auteur
Sebastian Loens
  • Fonction : Auteur
Laura Wright
  • Fonction : Auteur
Joel Perlmutter
  • Fonction : Auteur

Résumé

ABSTRACT Background Knowledge of characteristics in upper limb dystonia remains limited, derived primarily from small, single‐site studies. Objective The objective of this study was to characterize demographic and clinical characteristics of upper limb dystonia from the Dystonia Coalition data set, a large, international, multicenter resource. Methods We evaluated clinical and demographic characteristics of 367 participants with upper limb dystonia from onset, comparing across subcategories of focal (with and without dystonia spread) versus nonfocal onset. Results Focal onset occurred in 80%; 67% remained focal without spread. Task specificity was most frequent in this subgroup, most often writer's cramp and affecting the dominant limb (83%). Focal onset with spread was more frequent in young onset (<21 years). Focal onset occurred equally in women and men; nonfocal onset affected women disproportionately. Conclusions Upper limb dystonia distribution, focality, and task specificity relate to onset age and likelihood of regional spread. Observations may inform clinical counseling and design, execution, and interpretation of future studies. © 2020 International Parkinson and Movement Disorder Society.

Dates et versions

hal-04571072 , version 1 (07-05-2024)

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Scott Norris, Hyder Jinnah, Christine Klein, Joseph Jankovic, Brian Berman, et al.. Clinical and Demographic Characteristics of Upper Limb Dystonia. Movement Disorders, 2020, 35 (11), pp.2086-2090. ⟨10.1002/mds.28223⟩. ⟨hal-04571072⟩
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