The international European Academy of Neurology survey on neurological symptoms in patients with COVID‐19 infection
E. Moro
(1)
,
A. Priori
(2)
,
E. Beghi
(3)
,
R. Helbok
(4)
,
L. Campiglio
(2)
,
C. Bassetti
(5, 6)
,
E. Bianchi
(3)
,
L. Maia
(7)
,
S. Ozturk
(8)
,
F. Cavallieri
(9)
,
M. Zedde
(9)
,
J. Sellner
(10, 11)
,
D. Bereczki
(12)
,
M. Rakusa
(13)
,
G. Di Liberto
(14)
,
A. Sauerbier
(15, 16)
,
A. Pisani
(17)
,
A. Macerollo
(18, 19)
,
R. Soffietti
(20)
,
P. Taba
(21)
,
M. Crean
(22)
,
A. Twardzik
(22)
,
C. Oreja-Guevara
(23, 24)
,
B. Bodini
(25, 26)
,
T. Jenkins
(27, 28)
,
T. von Oertzen
1
GIN -
[GIN] Grenoble Institut des Neurosciences
2 UNIMI - Università degli Studi di Milano = University of Milan
3 IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri"
4 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
5 UNIBE - Universität Bern = University of Bern = Université de Berne
6 Inselspital - Bern University Hospital [Berne]
7 Centro Hospitalar do Porto
8 Selçuk University = Selçuk Üniversitesi
9 Reggio Emilia Hospital [Italy]
10 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
11 PMU - Paracelsus Medizinische Privatuniversität = Paracelsus Medical University
12 Semmelweis University [Budapest]
13 UKC Maribor - University medical centre Maribor
14 Faculté de médecine [Genève]
15 University Hospital of Cologne [Cologne]
16 KCH - King's College Hospital
17 Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
18 The Walton Centre NHS Foundation Trust
19 University of Liverpool
20 UNITO - Università degli studi di Torino = University of Turin
21 University of Tartu
22 Head Office - European Academy of Neurology [Vienna, Austria]
23 IdISSC - Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain]
24 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
25 CHU Saint-Antoine [AP-HP]
26 SU - Sorbonne Université
27 University of Sheffield [Sheffield]
28 Sheffield Teaching Hospitals NHS Foundation Trust [Sheffield, Royaume-Uni]
2 UNIMI - Università degli Studi di Milano = University of Milan
3 IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri"
4 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
5 UNIBE - Universität Bern = University of Bern = Université de Berne
6 Inselspital - Bern University Hospital [Berne]
7 Centro Hospitalar do Porto
8 Selçuk University = Selçuk Üniversitesi
9 Reggio Emilia Hospital [Italy]
10 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
11 PMU - Paracelsus Medizinische Privatuniversität = Paracelsus Medical University
12 Semmelweis University [Budapest]
13 UKC Maribor - University medical centre Maribor
14 Faculté de médecine [Genève]
15 University Hospital of Cologne [Cologne]
16 KCH - King's College Hospital
17 Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
18 The Walton Centre NHS Foundation Trust
19 University of Liverpool
20 UNITO - Università degli studi di Torino = University of Turin
21 University of Tartu
22 Head Office - European Academy of Neurology [Vienna, Austria]
23 IdISSC - Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain]
24 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
25 CHU Saint-Antoine [AP-HP]
26 SU - Sorbonne Université
27 University of Sheffield [Sheffield]
28 Sheffield Teaching Hospitals NHS Foundation Trust [Sheffield, Royaume-Uni]
E. Moro
- Fonction : Auteur
- PersonId : 1322290
- ORCID : 0000-0002-7968-5908
E. Beghi
- Fonction : Auteur
- PersonId : 1351846
- ORCID : 0000-0003-2542-0469
R. Helbok
- Fonction : Auteur
- PersonId : 1351845
- ORCID : 0000-0001-5682-0145
C. Bassetti
- Fonction : Auteur
- PersonId : 792710
- ORCID : 0000-0002-4535-0245
F. Cavallieri
- Fonction : Auteur
- PersonId : 1322282
- ORCID : 0000-0001-5836-1982
D. Bereczki
- Fonction : Auteur
- PersonId : 1351847
- ORCID : 0000-0002-8374-0500
M. Rakusa
- Fonction : Auteur
- PersonId : 1293611
- ORCID : 0000-0003-4433-3985
A. Pisani
- Fonction : Auteur
- PersonId : 799485
- ORCID : 0000-0002-8432-594X
- IdRef : 20185810X
A. Macerollo
- Fonction : Auteur
- PersonId : 1382515
- ORCID : 0000-0003-4322-2706
T. von Oertzen
- Fonction : Auteur
- PersonId : 1351851
- ORCID : 0000-0003-2164-7842
Résumé
Background and purpose Although the main clinical features of COVID‐19 infection are pulmonary, several associated neurological signs, symptoms and diseases are emerging. The incidence and characteristics of neurological complications are unclear. For this reason, the European Academy of Neurology (EAN) core COVID‐19 Task Force initiated a survey on neurological symptoms observed in patients with COVID‐19 infection. Methods A 17‐question online survey was made available on the EAN website and distributed to EAN members and other worldwide physicians starting on 9 April 2020. Results By 27 April 2020, proper data were collected from 2343 responders (out of 4199), of whom 82.0% were neurologists, mostly from Europe. Most responders (74.7%) consulted patients with COVID‐19 mainly in emergency rooms and in COVID‐19 units. The majority (67.0%) had evaluated fewer than 10 patients with neurological manifestations of COVID‐19 (neuro COVID‐19). The most frequently reported neurological findings were headache (61.9%), myalgia (50.4%), anosmia (49.2%), ageusia (39.8%), impaired consciousness (29.3%) and psychomotor agitation (26.7%). Encephalopathy and acute cerebrovascular disorders were reported at 21.0%. Neurological manifestations were generally interpreted as being possibly related to COVID‐19; they were most commonly recognized in patients with multiple general symptoms and occurred at any time during infection. Conclusion Neurologists are currently and actively involved in the management of neurological issues related to the COVID‐19 pandemic. This survey justifies setting up a prospective registry to better capture the prevalence of patients with neuro COVID‐19, neurological disease characteristics and the contribution of neurological manifestations to outcome.