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Journal Articles Clinical Journal of the American Society of Nephrology Year : 2019

Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults

Florent Guerville (1) , Philipe de Souto Barreto (2, 3) , Benjamin Taton (4, 5, 6) , Isabelle Bourdel-Marchasson (7) , Yves Rolland (8, 9) , Bruno Vellas (8, 9) , Sophie Guyonnet , Isabelle Carrié , Lauréane Brigitte , Catherine Faisant , Françoise Lala , Julien Delrieu , Hélène Villars , Emeline Combrouze , Carole Badufle , Audrey Zueras. Methodology , Sandrine Andrieu , Christelle Cantet , Christophe Morin , Gabor Abellan Van Kan , Charlotte Dupuy , Céline Caillaud , Pierre-Jean Ousset , Françoise Lala , Sherry Willis , And Sylvie Belleville , Brigitte Gilbert , Francine Fontaine , Jean-François Dartigues , Isabelle Marcet , Fleur Delva , Alexandra Foubert , And Sandrine Cerda , Marie-Noëlle-Cuffi And Corinne Costes , Olivier Rouaud , Patrick Manckoundia , Valérie Quipourt , Sophie Marilier , And Evelyne Franon , Lawrence Bories , Marie-Laure Pader , Marie-France Basset , Bruno Lapoujade , Valérie Faure , Michael Li Yung Tong , Christine Malick-Loiseau , Evelyne Cazaban-Campistron , Françoise Desclaux , Colette Blatge , Thierry Dantoine , Cécile Laubarie-Mouret , Isabelle Saulnier , Jean-Pierre Clément , Marie-Agnès Picat , Laurence Bernard-Bourzeix , Stéphanie Willebois , Iléana Désormais , Noëlle Cardinaud , Marc Bonnefoy , Pierre Livet , Pascale Rebaudet , Claire Gédéon , Catherine Burdet , Flavien Terracol , Alain Pesce , Stéphanie Roth , Sylvie Chaillou , Sandrine Louchart , Kristelle Sudres , Nicolas Lebrun , Nadège Barro-Belaygues , Jacques Touchon , Karim Bennys , Audrey Gabelle , Aurélia Romano , Lynda Touati , Cécilia Marelli , Cécile Pays , Philippe Robert , Franck Le Duff , Claire Gervais , Sébastien Gonfrier , Yannick Gasnier , Serge Bordes , Danièle Begorre , Christian Carpuat , Khaled Khales , Jean-François Lefebvre , Samira Misbah El Idrissi , Pierre Skolil , Jean-Pierre Salles , Carole Dufouil , Stéphane Lehéricy (10) , Marie Chupin , Jean-François Mangin , Ali Bouhayia , Michèle Allard , Frédéric Ricolfi , Dominique Dubois , Marie Paule Bonceour Martel , François Cotton , Alain Bonafé , Stéphane Chanalet , Françoise Hugon , Fabrice Bonneville , Christophe Cognard , François Chollet , Pierre Payoux , Thierry Voisin , Julien Delrieu , Sophie Peiffer , Anne Hitzel , Michèle Allard , Michel Zanca , Jacques Monteil , Jacques Darcourt , Laurent Molinier , Hélène Derumeaux , Nadège Costa , Bertrand Perret , Claire Vinel , Sylvie Caspar-Bauguil , Pascale Olivier-Abbal , Sandrine Andrieu , Christelle Cantet , Nicola Coley
Sophie Guyonnet
  • Function : Author
Isabelle Carrié
  • Function : Author
Lauréane Brigitte
  • Function : Author
Catherine Faisant
  • Function : Author
Françoise Lala
  • Function : Author
Julien Delrieu
  • Function : Author
Hélène Villars
  • Function : Author
Emeline Combrouze
  • Function : Author
Carole Badufle
  • Function : Author
Audrey Zueras. Methodology
  • Function : Author
Sandrine Andrieu
  • Function : Author
Christelle Cantet
  • Function : Author
Christophe Morin
  • Function : Author
Gabor Abellan Van Kan
  • Function : Author
Charlotte Dupuy
  • Function : Author
Céline Caillaud
  • Function : Author
Pierre-Jean Ousset
  • Function : Author
Françoise Lala
  • Function : Author
Sherry Willis
  • Function : Author
And Sylvie Belleville
  • Function : Author
Brigitte Gilbert
  • Function : Author
Francine Fontaine
  • Function : Author
Jean-François Dartigues
  • Function : Author
Isabelle Marcet
  • Function : Author
Fleur Delva
  • Function : Author
Alexandra Foubert
  • Function : Author
And Sandrine Cerda
  • Function : Author
Olivier Rouaud
  • Function : Author
Patrick Manckoundia
  • Function : Author
Valérie Quipourt
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Sophie Marilier
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And Evelyne Franon
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Lawrence Bories
  • Function : Author
Marie-Laure Pader
  • Function : Author
Marie-France Basset
  • Function : Author
Bruno Lapoujade
  • Function : Author
Valérie Faure
  • Function : Author
Michael Li Yung Tong
  • Function : Author
Christine Malick-Loiseau
  • Function : Author
Evelyne Cazaban-Campistron
  • Function : Author
Françoise Desclaux
  • Function : Author
Colette Blatge
  • Function : Author
Thierry Dantoine
  • Function : Author
Cécile Laubarie-Mouret
  • Function : Author
Isabelle Saulnier
  • Function : Author
Jean-Pierre Clément
  • Function : Author
Marie-Agnès Picat
  • Function : Author
Laurence Bernard-Bourzeix
  • Function : Author
Stéphanie Willebois
  • Function : Author
Iléana Désormais
  • Function : Author
Noëlle Cardinaud
  • Function : Author
Marc Bonnefoy
  • Function : Author
Pierre Livet
  • Function : Author
Pascale Rebaudet
  • Function : Author
Claire Gédéon
  • Function : Author
Catherine Burdet
  • Function : Author
Flavien Terracol
  • Function : Author
Alain Pesce
  • Function : Author
Stéphanie Roth
  • Function : Author
Sylvie Chaillou
  • Function : Author
Sandrine Louchart
  • Function : Author
Kristelle Sudres
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Nicolas Lebrun
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Nadège Barro-Belaygues
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Jacques Touchon
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Karim Bennys
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Audrey Gabelle
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Aurélia Romano
  • Function : Author
Lynda Touati
  • Function : Author
Cécilia Marelli
  • Function : Author
Cécile Pays
  • Function : Author
Philippe Robert
  • Function : Author
Franck Le Duff
  • Function : Author
Claire Gervais
  • Function : Author
Sébastien Gonfrier
  • Function : Author
Yannick Gasnier
  • Function : Author
Serge Bordes
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Danièle Begorre
  • Function : Author
Christian Carpuat
  • Function : Author
Khaled Khales
  • Function : Author
Jean-François Lefebvre
  • Function : Author
Samira Misbah El Idrissi
  • Function : Author
Pierre Skolil
  • Function : Author
Jean-Pierre Salles
  • Function : Author
Carole Dufouil
  • Function : Author
Marie Chupin
  • Function : Author
Jean-François Mangin
  • Function : Author
Ali Bouhayia
  • Function : Author
Michèle Allard
  • Function : Author
Frédéric Ricolfi
  • Function : Author
Dominique Dubois
  • Function : Author
Marie Paule Bonceour Martel
  • Function : Author
François Cotton
  • Function : Author
Alain Bonafé
  • Function : Author
Stéphane Chanalet
  • Function : Author
Françoise Hugon
  • Function : Author
Fabrice Bonneville
  • Function : Author
Christophe Cognard
  • Function : Author
François Chollet
  • Function : Author
Pierre Payoux
  • Function : Author
Thierry Voisin
  • Function : Author
Julien Delrieu
  • Function : Author
Sophie Peiffer
  • Function : Author
Anne Hitzel
  • Function : Author
Michèle Allard
  • Function : Author
Michel Zanca
  • Function : Author
Jacques Monteil
  • Function : Author
Jacques Darcourt
  • Function : Author
Laurent Molinier
  • Function : Author
Hélène Derumeaux
  • Function : Author
Nadège Costa
  • Function : Author
Bertrand Perret
  • Function : Author
Claire Vinel
  • Function : Author
Sylvie Caspar-Bauguil
  • Function : Author
Pascale Olivier-Abbal
  • Function : Author
Sandrine Andrieu
  • Function : Author
Christelle Cantet
  • Function : Author
Nicola Coley
  • Function : Author

Abstract

Background and objectives Low eGFR is known to be associated with frailty, but the association between the longitudinal decline of eGFR and incident frailty in older persons remains to be determined. The objective of this study was to investigate whether a fast decline on eGFR would be associated with incident frailty. Design, setting, participants, & measurements Community dwellers, aged ≥70, were included in this secondary analysis of the 5-year Multidomain Alzheimer Preventive Trial (MAPT). eGFR was calculated using CKD–Epidemiology Collaboration equation at baseline and at 6, 12, and 24 months. The lowest quartile of eGFR slope (−4.1 ml/min per 1.73 m 2 per yr) defined a fast decline. The frailty phenotype (unintentional weight loss, exhaustion, low physical activity, slow gait, low handgrip strength assessed with a 0–5 score, where higher is worse; a score ≥3 defines frailty) was assessed at baseline, 6, 12, 24, 36, 48, and 60 months. Cox models were used to test the association between fast eGFR decline and incident frailty. Results A total of 833 participants were frail neither at baseline nor at 2 years and had appropriate follow-up data. Median (IQR) baseline eGFR was 73 (61–84) ml/min per 1.73 m 2 . Frailty occurred in 95 (11%) participants between 24 and 60 months. Among them, 31/207 (15%) had fast eGFR decline between baseline and 24 months, and 64/626 (10%) did not. In a Cox model adjusted for demographic variables, cardiovascular comorbidity, C-reactive protein, and baseline eGFR, a fast eGFR decline was associated with incident frailty (HR 1.67, 95% CI 1.03 to 2.71). Sensitivity analyses provided consistent findings. Conclusions In community-dwelling older adults with relatively preserved baseline eGFR, a fast eGFR decline is associated with incident frailty.

Dates and versions

hal-04578814 , version 1 (17-05-2024)

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Florent Guerville, Philipe de Souto Barreto, Benjamin Taton, Isabelle Bourdel-Marchasson, Yves Rolland, et al.. Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults. Clinical Journal of the American Society of Nephrology, 2019, 14 (11), pp.1597-1604. ⟨10.2215/CJN.03750319⟩. ⟨hal-04578814⟩
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