Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults

Florent Guerville; Philipe de Souto Barreto; Benjamin Taton; Isabelle Bourdel-Marchasson; Yves Rolland; Bruno Vellas; Sophie Guyonnet; Isabelle Carrié; Lauréane Brigitte; Catherine Faisant; Françoise Lala; Julien Delrieu; Hélène Villars; Emeline Combrouze; Carole Badufle; Audrey Zueras. Methodology; Sandrine Andrieu; Christelle Cantet; Christophe Morin; Gabor Abellan Van Kan; Charlotte Dupuy; Céline Caillaud; Pierre-Jean Ousset; Françoise Lala; Sherry Willis; And Sylvie Belleville; Brigitte Gilbert; Francine Fontaine; Jean-François Dartigues; Isabelle Marcet; Fleur Delva; Alexandra Foubert; And Sandrine Cerda; Marie-Noëlle-Cuffi And Corinne Costes; Olivier Rouaud; Patrick Manckoundia; Valérie Quipourt; Sophie Marilier; And Evelyne Franon; Lawrence Bories; Marie-Laure Pader; Marie-France Basset; Bruno Lapoujade; Valérie Faure; Michael Li Yung Tong; Christine Malick-Loiseau; Evelyne Cazaban-Campistron; Françoise Desclaux; Colette Blatge; Thierry Dantoine; Cécile Laubarie-Mouret; Isabelle Saulnier; Jean-Pierre Clément; Marie-Agnès Picat; Laurence Bernard-Bourzeix; Stéphanie Willebois; Iléana Désormais; Noëlle Cardinaud; Marc Bonnefoy; Pierre Livet; Pascale Rebaudet; Claire Gédéon; Catherine Burdet; Flavien Terracol; Alain Pesce; Stéphanie Roth; Sylvie Chaillou; Sandrine Louchart; Kristelle Sudres; Nicolas Lebrun; Nadège Barro-Belaygues; Jacques Touchon; Karim Bennys; Audrey Gabelle; Aurélia Romano; Lynda Touati; Cécilia Marelli; Cécile Pays; Philippe Robert; Franck Le Duff; Claire Gervais; Sébastien Gonfrier; Yannick Gasnier; Serge Bordes; Danièle Begorre; Christian Carpuat; Khaled Khales; Jean-François Lefebvre; Samira Misbah El Idrissi; Pierre Skolil; Jean-Pierre Salles; Carole Dufouil; Stéphane Lehéricy; Marie Chupin; Jean-François Mangin; Ali Bouhayia; Michèle Allard; Frédéric Ricolfi; Dominique Dubois; Marie Paule Bonceour Martel; François Cotton; Alain Bonafé; Stéphane Chanalet; Françoise Hugon; Fabrice Bonneville; Christophe Cognard; François Chollet; Pierre Payoux; Thierry Voisin; Julien Delrieu; Sophie Peiffer; Anne Hitzel; Michèle Allard; Michel Zanca; Jacques Monteil; Jacques Darcourt; Laurent Molinier; Hélène Derumeaux; Nadège Costa; Bertrand Perret; Claire Vinel; Sylvie Caspar-Bauguil; Pascale Olivier-Abbal; Sandrine Andrieu; Christelle Cantet; Nicola Coley

doi:10.2215/CJN.03750319

Journal Articles Clinical Journal of the American Society of Nephrology Year : 2019

Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults

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Florent Guerville

Function : Author
PersonId : 1383504
ORCID : 0000-0002-9509-1771

Gérontopôle

Institut du Vieillissement

Philipe de Souto Barreto

Function : Author
PersonId : 865365
ORCID : 0000-0002-8860-425X

Gérontopôle

Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps

Institut du Vieillissement

Benjamin Taton

Function : Author
PersonId : 1383505
ORCID : 0000-0001-9609-8652

Université de Bordeaux

Modélisation Mathématique pour l'Oncologie

Centre Hospitalier Universitaire de Bordeaux

Isabelle Bourdel-Marchasson

Function : Author

Service de médecine gériatrique

Yves Rolland

Function : Author
PersonId : 946609
ORCID : 0000-0002-1157-0215

Gérontopôle

Institut du Vieillissement

Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps

Bruno Vellas

Function : Author
PersonId : 933362
ORCID : 0000-0002-7678-5065
IdRef : 03566729X

Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps

Gérontopôle

Institut du Vieillissement

Sophie Guyonnet

Function : Author

Isabelle Carrié

Function : Author

Lauréane Brigitte

Function : Author

Catherine Faisant

Function : Author

Françoise Lala

Function : Author

Julien Delrieu

Function : Author

Hélène Villars

Function : Author

Emeline Combrouze

Function : Author

Carole Badufle

Function : Author

Audrey Zueras. Methodology

Function : Author

Sandrine Andrieu

Function : Author

Christelle Cantet

Function : Author

Christophe Morin

Function : Author

Gabor Abellan Van Kan

Function : Author

Charlotte Dupuy

Function : Author

Céline Caillaud

Function : Author

Pierre-Jean Ousset

Function : Author

Françoise Lala

Function : Author

Sherry Willis

Function : Author

And Sylvie Belleville

Function : Author

Brigitte Gilbert

Function : Author
PersonId : 1236595
ORCID : 0000-0001-7182-9914
IdRef : 081235380

Francine Fontaine

Function : Author

Jean-François Dartigues

Function : Author

Isabelle Marcet

Function : Author

Fleur Delva

Function : Author

Alexandra Foubert

Function : Author

And Sandrine Cerda

Function : Author

Marie-Noëlle-Cuffi And Corinne Costes

Function : Author

Olivier Rouaud

Function : Author

Patrick Manckoundia

Function : Author

Valérie Quipourt

Function : Author

Sophie Marilier

Function : Author

And Evelyne Franon

Function : Author

Lawrence Bories

Function : Author

Marie-Laure Pader

Function : Author

Marie-France Basset

Function : Author

Bruno Lapoujade

Function : Author

Valérie Faure

Function : Author

Michael Li Yung Tong

Function : Author

Christine Malick-Loiseau

Function : Author

Evelyne Cazaban-Campistron

Function : Author

Françoise Desclaux

Function : Author

Colette Blatge

Function : Author

Thierry Dantoine

Function : Author

Cécile Laubarie-Mouret

Function : Author

Isabelle Saulnier

Function : Author

Jean-Pierre Clément

Function : Author

Marie-Agnès Picat

Function : Author

Laurence Bernard-Bourzeix

Function : Author

Stéphanie Willebois

Function : Author

Iléana Désormais

Function : Author

Noëlle Cardinaud

Function : Author

Marc Bonnefoy

Function : Author

Pierre Livet

Function : Author

Pascale Rebaudet

Function : Author

Claire Gédéon

Function : Author

Catherine Burdet

Function : Author

Flavien Terracol

Function : Author

Alain Pesce

Function : Author

Stéphanie Roth

Function : Author

Sylvie Chaillou

Function : Author

Sandrine Louchart

Function : Author

Kristelle Sudres

Function : Author

Nicolas Lebrun

Function : Author
PersonId : 1326826

Nadège Barro-Belaygues

Function : Author

Jacques Touchon

Function : Author

Karim Bennys

Function : Author

Audrey Gabelle

Function : Author

Aurélia Romano

Function : Author

Lynda Touati

Function : Author

Cécilia Marelli

Function : Author

Cécile Pays

Function : Author

Philippe Robert

Function : Author

Franck Le Duff

Function : Author

Claire Gervais

Function : Author

Sébastien Gonfrier

Function : Author

Yannick Gasnier

Function : Author

Serge Bordes

Function : Author

Danièle Begorre

Function : Author

Christian Carpuat

Function : Author

Khaled Khales

Function : Author

Jean-François Lefebvre

Function : Author

Samira Misbah El Idrissi

Function : Author

Pierre Skolil

Function : Author

Jean-Pierre Salles

Function : Author

Carole Dufouil

Function : Author

Stéphane Lehéricy

Function : Author
PersonId : 1288251
ORCID : 0000-0002-5802-3518
IdRef : 089427513

Institut du Cerveau = Paris Brain Institute

Marie Chupin

Function : Author

Jean-François Mangin

Function : Author

Ali Bouhayia

Function : Author

Michèle Allard

Function : Author

Frédéric Ricolfi

Function : Author

Dominique Dubois

Function : Author

Marie Paule Bonceour Martel

Function : Author

François Cotton

Function : Author
PersonId : 170687
IdHAL : francois-cotton
ORCID : 0000-0003-0046-2478
IdRef : 070732035

Alain Bonafé

Function : Author

Stéphane Chanalet

Function : Author

Françoise Hugon

Function : Author

Fabrice Bonneville

Function : Author

Christophe Cognard

Function : Author

François Chollet

Function : Author

Pierre Payoux

Function : Author

Thierry Voisin

Function : Author

Julien Delrieu

Function : Author

Sophie Peiffer

Function : Author

Anne Hitzel

Function : Author

Michèle Allard

Function : Author

Michel Zanca

Function : Author

Jacques Monteil

Function : Author

Jacques Darcourt

Function : Author

Laurent Molinier

Function : Author

Hélène Derumeaux

Function : Author

Nadège Costa

Function : Author

Bertrand Perret

Function : Author

Claire Vinel

Function : Author

Sylvie Caspar-Bauguil

Function : Author

Pascale Olivier-Abbal

Function : Author

Sandrine Andrieu

Function : Author

Christelle Cantet

Function : Author

Nicola Coley

Function : Author

Abstract

Background and objectives Low eGFR is known to be associated with frailty, but the association between the longitudinal decline of eGFR and incident frailty in older persons remains to be determined. The objective of this study was to investigate whether a fast decline on eGFR would be associated with incident frailty. Design, setting, participants, & measurements Community dwellers, aged ≥70, were included in this secondary analysis of the 5-year Multidomain Alzheimer Preventive Trial (MAPT). eGFR was calculated using CKD–Epidemiology Collaboration equation at baseline and at 6, 12, and 24 months. The lowest quartile of eGFR slope (−4.1 ml/min per 1.73 m 2 per yr) defined a fast decline. The frailty phenotype (unintentional weight loss, exhaustion, low physical activity, slow gait, low handgrip strength assessed with a 0–5 score, where higher is worse; a score ≥3 defines frailty) was assessed at baseline, 6, 12, 24, 36, 48, and 60 months. Cox models were used to test the association between fast eGFR decline and incident frailty. Results A total of 833 participants were frail neither at baseline nor at 2 years and had appropriate follow-up data. Median (IQR) baseline eGFR was 73 (61–84) ml/min per 1.73 m 2 . Frailty occurred in 95 (11%) participants between 24 and 60 months. Among them, 31/207 (15%) had fast eGFR decline between baseline and 24 months, and 64/626 (10%) did not. In a Cox model adjusted for demographic variables, cardiovascular comorbidity, C-reactive protein, and baseline eGFR, a fast eGFR decline was associated with incident frailty (HR 1.67, 95% CI 1.03 to 2.71). Sensitivity analyses provided consistent findings. Conclusions In community-dwelling older adults with relatively preserved baseline eGFR, a fast eGFR decline is associated with incident frailty.

Keywords

C-reactive protein EGFR protein chronic renal insufficiency comorbidity epidermal growth factor exercise follow-up studies frailty gait geriatric nephrology glomerular filtration rate hand strength human independent living older persons phenotype progression of renal failure proportional hazards models receptor weight loss

Domains

Human health and pathology

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https://hal.sorbonne-universite.fr/hal-04578814

Submitted on : Friday, May 17, 2024-10:58:03 AM

Last modification on : Thursday, November 28, 2024-5:57:36 PM

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hal-04578814 , version 1 (17-05-2024)

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HAL Id : hal-04578814 , version 1
DOI : 10.2215/CJN.03750319
PUBMED : 31628118
PUBMEDCENTRAL : PMC6832058

Cite

Florent Guerville, Philipe de Souto Barreto, Benjamin Taton, Isabelle Bourdel-Marchasson, Yves Rolland, et al.. Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults. Clinical Journal of the American Society of Nephrology, 2019, 14 (11), pp.1597-1604. ⟨10.2215/CJN.03750319⟩. ⟨hal-04578814⟩

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Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults

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