Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia - Sorbonne Université Access content directly
Journal Articles The Cerebellum Year : 2016

Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia

Abstract

A role for the cerebellum in causing ataxia, a disorder characterized by uncoordinated movement, is widely accepted. Recent work has suggested that alterations in activity, connectivity, and structure of the cerebellum are also associated with dystonia, a neurological disorder characterized by abnormal and sustained muscle contractions often leading to abnormal maintained postures. In this manuscript, the authors discuss their views on how the cerebellum may play a role in dystonia. The following topics are discussed: The relationships between neuronal/network dysfunctions and motor abnormalities in rodent models of dystonia.Data about brain structure, cerebellar metabolism, cerebellar connections, and noninvasive cerebellar stimulation that support (or not) a role for the cerebellum in human dystonia.Connections between the cerebellum and motor cortical and sub-cortical structures that could support a role for the cerebellum in dystonia. Overall points of consensus include: Neuronal dysfunction originating in the cerebellum can drive dystonic movements in rodent model systems.Imaging and neurophysiological studies in humans suggest that the cerebellum plays a role in the pathophysiology of dystonia, but do not provide conclusive evidence that the cerebellum is the primary or sole neuroanatomical site of origin.
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Dates and versions

hal-04590420 , version 1 (28-05-2024)

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Vikram G Shakkottai, Amit Batla, Kailash Bhatia, William T Dauer, Christian Dresel, et al.. Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia. The Cerebellum, 2016, 16 (2), pp.577-594. ⟨10.1007/s12311-016-0825-6⟩. ⟨hal-04590420⟩
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