Sphingosine‐1‐phosphate signalling in the heart: exploring emerging perspectives in cardiopathology - Sorbonne Université
Journal Articles FEBS Letters Year : 2024

Sphingosine‐1‐phosphate signalling in the heart: exploring emerging perspectives in cardiopathology

Abstract

Cardiometabolic disorders contribute to the global burden of cardiovascular diseases. Emerging sphingolipid metabolites like sphingosine‐1‐phosphate (S1P) and its receptors, S1PRs, present a dynamic signalling axis significantly impacting cardiac homeostasis. S1P's intricate mechanisms extend to its transportation in the bloodstream by two specific carriers: high‐density lipoprotein particles and albumin. This intricate transport system ensures the accessibility of S1P to distant target tissues, influencing several physiological processes critical for cardiovascular health. This review delves into the diverse functions of S1P and S1PRs in both physiological and pathophysiological conditions of the heart. Emphasis is placed on their diverse roles in modulating cardiac health, spanning from cardiac contractility, angiogenesis, inflammation, atherosclerosis and myocardial infarction. The intricate interplays involving S1P and its receptors are analysed concerning different cardiac cell types, shedding light on their respective roles in different heart diseases. We also review the therapeutic applications of targeting S1P/S1PRs in cardiac diseases, considering existing drugs like Fingolimod, as well as the prospects and challenges in developing novel therapies that selectively modulate S1PRs.

Dates and versions

hal-04726365 , version 1 (08-10-2024)

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Franck Phan, Olivier Bourron, Fabienne Foufelle, Hervé Le Stunff, Eric Hajduch. Sphingosine‐1‐phosphate signalling in the heart: exploring emerging perspectives in cardiopathology. FEBS Letters, 2024, Online ahead of print. ⟨10.1002/1873-3468.14973⟩. ⟨hal-04726365⟩
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